Cancer and Chemoprevention: An Overview

Front Matter....Pages i-xvii
Introduction....Pages 1-2
Hallmarks of Cancer Cell....Pages 3-13
Classification of Cancer....Pages 15-16
Factors Affecting Cancer Development....Pages 17-19
Carcinogenesis....Pages 21-25
Molecular Mechanism of Carcinogenesis....Pages 27-29
Oxidative Stress-Induced Carcinogenesis....Pages 31-33
Major Mediators Linking Inflammation and Cancer....Pages 35-45
Apoptosis....Pages 47-50
Chemoprevention....Pages 51-56
Classification of Chemopreventive Agents....Pages 57-63
Preclinical Development of Chemopreventive Agents for Chemoprevention....Pages 65-77
Modulation of Wnt/β-Catenin Signaling by Chemoprevention....Pages 79-92
Modulation of Akt/mTOR Pathway Signaling by Chemoprevention....Pages 93-103
Novel Chemopreventive Agents....Pages 105-107
Chemoprevention by Resveratrol....Pages 109-114
Chemoprevention by Genistein....Pages 115-127
Chemoprevention by Apigenin....Pages 129-131
Chemoprevention by Curcumin....Pages 133-138
Chemoprevention by Fisetin....Pages 139-142
Chemoprevention by Epigallocatechin-3-Gallate (EGCG)....Pages 143-152
Chemoprevention by Graviola....Pages 153-155
Cancer Chemoprevention: Hurdles and Future Prospects and Considerations....Pages 157-161
Clinical Trials of Chemoprevention....Pages 163-167
Future of Chemoprevention....Pages 169-173