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دانلود کتاب Atherosclerosis IV: Proceedings of the Fourth International Symposium
دانلود کتاب آترواسکلروز IV: مجموعه مقالات چهارمین سمپوزیوم بین المللی
مشخصات کتاب
Atherosclerosis IV: Proceedings of the Fourth International Symposium
ویرایش: 1 نویسندگان: C. J. Schwartz, R. G. Gerrity, L. J. Lewis, G. M. Chisolm, K. N. Bretherton (auth.), G. Schettler, Y. Goto, Y. Hata, G. Klose (eds.) سری: ISBN (شابک) : 9783642953101, 9783642953088 ناشر: Springer-Verlag Berlin Heidelberg سال نشر: 1977 تعداد صفحات: 834 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 44 مگابایت
قیمت کتاب (تومان) : 43,000
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توجه داشته باشید کتاب آترواسکلروز IV: مجموعه مقالات چهارمین سمپوزیوم بین المللی نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب آترواسکلروز IV: مجموعه مقالات چهارمین سمپوزیوم بین المللی
وجود مونوتایپیسم در ضایعات آترواسکلروتیک ضخیم زنان سیاه پوست مبتلا به موزائیسم G-6-PD برای اولین بار توسط Benditts (1973) در دو آزمایشگاه دیگر گزارش شده است. با این حال، ما معتقدیم که زود است نتیجه گیری کنیم که یافته مونوتایپیسم لزوماً نشان دهنده منشا مونوکلونال ضایعات آترو اسکلروتیک است. ما دو توضیح جایگزین برای مشاهده یکنواختی پیشنهاد کرده‌ایم که معتقدیم قبل از پذیرفتن منشأ مونوکلونال به‌عنوان تنها راه معقول برای توضیح مونوتایپیسم G-6-PD باید نشان داده شود که معتبر نیستند. یکی از این دو جایگزین مربوط به ناهمگنی کلونال پتانسیل رشد سلولی است، i. ه. در طول رشد تدریجی یک ضایعه، نتاج یک سلول ممکن است در بخشی از ضایعه بیش از حد رشد کند. جایگزین دیگر این است که یکی از آلل های G-6-PD ممکن است به ژن هایی مرتبط باشد که ویژگی بقای ترجیحی را در محیط غیر طبیعی موجود در ضایعات آترواسکروتیک ایجاد می کنند. بنابراین، سلول‌های دارای یک آلل ممکن است بهتر از سلول‌هایی با آلل دیگر رشد کنند و این ویژگی ممکن است با \"A-ness\" یا \"B-ness\" ارتباطی نداشته باشد. ما شروع ضایعات را در خوکی‌های تغذیه‌شده با او مطالعه کرده‌ایم و نشان دادیم که تمام ضایعات فعالی که مورد مطالعه قرار گرفته‌اند منشا سلولی چندگانه دارند (نه مونوکلونال). ما الگوهای رشد سلولی را در ایجاد ضایعات آترواسکلروتیک در خوکی‌های تغذیه‌شده با رژیم او مطالعه کرده‌ایم و شواهدی را یافتیم که با ناهمگنی کلونال در پتانسیل رشد سلول‌های ضایعه سازگار است.
توضیحاتی درمورد کتاب به خارجی
The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.
فهرست مطالب
Front Matter....Pages I-XLVI
Front Matter....Pages XLVII-XLVII
Arterial Endothelial Permeability to Macromolecules....Pages 1-11
The Maintenance of Endothelial Integrity....Pages 12-15
Arterial Smooth Muscle Cells in Atherogenesis: Births, Deaths and Clonal Phenomena....Pages 16-23
Lipoproteins — Steady State Aspects....Pages 24-29
Connective Tissue in Atherosclerosis....Pages 30-35
Immunologic Mechanism of Atherosclerosis....Pages 36-44
Introduction....Pages 45-46
Uptake of Serum Lipoproteins into the Arterial Wall....Pages 46-48
Enzymes Catalyzing Phospholipid-Dependent Transacylations in the Arterial Wall....Pages 48-51
Heparin-Manganese Precipitability of Canine Lipoproteins as Correlated with Binding to the Cell Surface Receptors on Fibroblasts....Pages 52-56
Synthesis and Removal of Free Cholesterol and of Cholesterol Ester by Smooth Muscle Cells in Tissue Culture....Pages 57-62
Abstract....Pages 63-72
Possibilities of Hyaline Formation in the Vessel Wall, Light- and Electron Microscopic Structure: Problems of Nomenclature....Pages 73-79
Hypertension, Stroke and Atherogenesis in Experimental Models....Pages 79-83
Hypertension and Cerebral Atherosclerosis....Pages 83-87
Abstracts....Pages 88-91
An Introduction to the Epidemiology of Atherosclerosis....Pages 92-98
Association between Risk Factors and Atherosclerotic Lesions Based on Autopsy Findings in the Oslo Study: A Preliminary Report....Pages 98-102
Atherosclerosis and Risk Factors....Pages 102-104
Coronary Risk Factors in Adults: The Influence of Nutrition in Early Life....Pages 104-108
Front Matter....Pages XLVII-XLVII
The Relation of Ante Mortem Factors to Atherosclerosis at Necropsy....Pages 108-113
Atherosclerosis and its Risk Factors in the Hawaiian Japanese....Pages 113-116
Atherosclerosis in Relation to Personal Attributes of a Japanese Population in Homes for the Aged....Pages 116-120
Frequency of Coronary and Peripheral Artery Disease in Hyperlipoproteinemia....Pages 120-123
Concluding Remarks on the Epidemiology of Atherosclerosis....Pages 124-124
Abstracts....Pages 125-128
Kinetics of VLDL Subfractions....Pages 129-132
Comparison of Methods of Plasma Triglyceride Turnover....Pages 132-137
The Intravenous Fat Tolerance Test with Intralipid — Validity, Applications, and Limitations....Pages 137-141
Triglyceride Turnover in Diabetic States of Dogs....Pages 141-145
Abstracts....Pages 146-148
Epidemiological Research in Japan on Smoking and Cardiovascular Diseases....Pages 149-156
Atherogenic Compounds of Tobacco Smoke....Pages 156-161
Abnormalities Potentially Mediating the Effect of Cigarette Smoking on Atherosclerosis....Pages 161-165
Oxygen Transport and Smoking....Pages 165-166
The Evidence for Nicotine as an Etiological Factor in Cardiovascular Disease (CVD)....Pages 167-169
Abstracts....Pages 170-173
Front Matter....Pages 175-175
Structure of the Plasma Lipoproteins — A Review....Pages 177-188
Cellular Catabolism of Serum Lipoproteins....Pages 189-191
Synthesis and Secretion of Plasma Lipoproteins and Apo-Lipoproteins....Pages 192-196
Front Matter....Pages 175-175
Dynamics of Lipoprotein Interconversion....Pages 197-204
Lipoprotein Metabolism in Tissue Culture....Pages 205-208
Current Concepts of Hyperlipoproteinemia....Pages 209-219
Electroimmunoassays of Serum Apolipoproteins in Normolipidemic Subjects and Patients with Primary Hyperlipoproteinemias....Pages 220-222
Lipid Organization in Human Plasma Low-Density Lipoproteins....Pages 222-227
Formation and Structural Properties of Lipoprotein-X....Pages 228-233
Isothermal Calorimetric Studies on Human HDL Apolipoproteins....Pages 233-237
High-Density Lipoprotein Abnormalities Associated with Disease....Pages 238-241
On the Role of Apolipoprotein A-I in the Structure of Serum High-Density Lipoproteins (HDL)....Pages 241-246
Abstracts....Pages 247-258
Requirement for Regression Studies in Animal Models....Pages 259-263
The Effect of Strenuous Exercise on Plasma Lipids and Atherosclerosis in Cholesterol-Fed Cockerels....Pages 263-268
Changes of Cyclic Nucleotides in the Regressive Course of Experimental Atherosclerosis and their Modification by Sex Hormones and Phthalazinol....Pages 268-273
Model of Arterial Injury by Balloon De-Endothelialization: Reappraisal, Improvement, and Application to Measurement of Endothelial Growth....Pages 273-274
Reversibility of Atherosclerosis in Pyridoxine-Deficient Monkeys....Pages 275-278
Regression of Atherosclerosis at Plasma Cholesterol Concentrations Achievable in Man....Pages 278-280
Aortic Atherosclerosis of Primates....Pages 280-285
Abstracts....Pages 286-292
Cholesterol Metabolism in High- and Low-Responding Rhesus Monkeys....Pages 293-298
Relationships Between Metabolism of Cholesterol and the Turnover of Plasma Lipoproteins....Pages 298-301
Front Matter....Pages 175-175
Studies on the Mechanism of Development of Hypercholesterolemia: Effect of Aging and Genetic Factors in Animal Models....Pages 301-304
Cholesterol Synthesis in Slowly Exchangeable Cholesterol Pool in Man....Pages 305-308
Bile Acid Metabolism under Basal and Experimental Conditions in Normo- and Hyperlipidemic Subjects....Pages 308-311
Cholesterol Turnover and Metabolism in Normal and Hyperlipidemic Humans....Pages 311-314
Abstracts....Pages 315-321
Hormones, Lipoprotein Lipase and Atherosclerosis....Pages 322-322
Molecular Aspects of Hepatic Triglyceride Lipase and Lipoprotein Lipase from Human Post-Heparin Plasma....Pages 322-325
The Interactions of Lipoprotein Lipases with Cofactor Proteins Lipid Substrate, and Certain Sulfated Polysaccharides....Pages 325-328
Purified Monoacylglycerol Hydrolase from Human Post-Heparin Plasma: Characteristics and Role in the Reaction Catalyzed by Lipoprotein Lipase....Pages 328-332
Measurement of Post-Heparin Plasma Lipoprotein Lipase and Hepatic Triglyceride Lipase Activities and Their Relation to Plasma Triglyceride Metabolism....Pages 332-336
Hormonal Regulation of Human Adipose Tissue Lipoprotein Lipase....Pages 336-341
Post-Heparin Triglyceride Lipase Activity (PHTGLA) in Diabetic Rats....Pages 342-343
Abstracts....Pages 344-349
Influence of Muscular Training on Arterial Wall Cell Reaction....Pages 350-353
Complex Carbohydrates of Arterial Wall Connective Tissue....Pages 353-357
New Results on Gag and Collagen in Atherosclerosis....Pages 357-362
Functional Relations Among Cells and Fibers of the Aortic Media: Microanatomic and Biosynthetic Findings....Pages 362-365
Abstracts....Pages 366-373
Front Matter....Pages 375-375
Animal Models of Regression....Pages 377-385
Methods to Accelerate Regression....Pages 386-393
Front Matter....Pages 375-375
The Mechanism of Atherosclerosis Regression....Pages 394-404
Connective Tissue Changes in Regression....Pages 405-413
Angiographic Evidence of Atherosclerosis Regression in Man....Pages 414-421
Enhancement of Regression of Human Atherosclerosis....Pages 422-436
Influence of all Nutrients on Atherosclerosis....Pages 437-438
Influence of Diet Factors on Plasma Lipids in Ischemic Heart Disease....Pages 438-441
Practical Considerations of Changing Dietary Cholesterol and Fat....Pages 442-445
Dietary Protein, Hypercholesterolemia, and Atherosclerosis....Pages 445-448
Soybean Protein Diet in the Treatment of Hypercholesterolemia....Pages 448-453
Abstracts....Pages 454-457
Front Matter....Pages 459-459
Epidemiological Studies of Atherosclerotic Disease in Japan....Pages 461-470
Highlights of Epidemiological Research in Western Countries....Pages 471-478
Abstracts....Pages 479-485
Front Matter....Pages 487-487
Risk Factors in Children — The Early Natural History of Atherosclerosis....Pages 489-497
Morphologic Apsects of Childhood Atherosclerosis....Pages 498-505
Abstracts....Pages 506-508
Front Matter....Pages 509-509
Dietary Management of Atherosclerosis....Pages 511-516
Drugs and Atherosclerosis....Pages 517-527
Surgical Management of Hyperlipidemia....Pages 528-535
Metabolic Aspects of the Management of Obliterative Atherosclerosis....Pages 536-542
Front Matter....Pages 509-509
Abstracts....Pages 543-558
Mechanisms of Hyperlipoproteinaemia Derived from Multicompartmental Analysis of Very Low-Density Apolipoprotein B-Kinetics....Pages 559-562
On the Significance of Typing of Hyperlipoproteinemia in Primary Asymptomatic Hyperlipidemia....Pages 563-566
Secondary Causes and Aggravating Factors for Hyperlipoproteinemia....Pages 566-570
Diagnosis of Type III Hyperlipoproteinemia by Means of Rate Zonal Ultracentrifugation....Pages 570-573
Some Aspects of Sensitivity and Resistance to the Cholesterol Lowering Effect of Clofibrate....Pages 573-576
Newer Methods of Treatment of the Hyperlipoproteinemias....Pages 576-580
Analysis of the Characteristics of β-K Band in the Fraction of Lipoprotein by Polyacrylamide Gel-Disc Electrophoresis and the Frequency of its Appearance in IHD....Pages 580-583
Nutritional Factors and Atherosclerosis....Pages 583-588
Abstracts....Pages 589-593
Introduction....Pages 594-594
Structure of the Renal Artery and its Vasoconstriction....Pages 594-596
Coronary Arterial Changes in Childhood and Young Adults with Respect to Progression of Coronary Sclerosis and a Brief Comment on Thrombosis as a Complication....Pages 597-600
Thrombosis and Endothelial Injury in Atherogenesis....Pages 601-605
Platelet Factors and the Proliferation of Vascular Smooth Muscle Cells....Pages 605-609
Thrombogenic and Atherogenic Effects of Dietary Fats....Pages 609-612
Scanning and Transmission Electron Microscopic Studies on Experimental Thrombosis in Rabbits....Pages 613-616
Abstracts....Pages 617-623
Proliferative Response of Arterial Smooth Muscle Cells to Hyperlipemia....Pages 624-627
Cholesterol Ester Synthesis by Microsomal Fractions from Fu5AH RAT Hepatoma Cells: Stimulation by Lipoproteins from Hyperlipemic Sera....Pages 627-631
Front Matter....Pages 509-509
Inhibition of Lipid Synthesis by Sulfated Glycans in Cultured Aortic Cells....Pages 632-635
The Effect of Hypoxia and Carbon Monoxide on Arterial Smooth Muscle Cell Cultures....Pages 636-639
Sterol Metabolism in Cultured Human Endothelial Cells....Pages 639-642
Effect of Human Sera on DNA Synthesis in Aortic Explants....Pages 642-644
Abstracts....Pages 645-649
Introduction....Pages 650-650
Studies on the Atherogenesis and Sucrose Intake in Crab-Eating Monkeys....Pages 650-654
Ascorbic Acid and Atherosclerosis: Effects of Chronic Hypovitamin C on Aortic Ground Substance and Lipid Metabolism....Pages 654-658
Ethanol-Lipemia — A Doubtful Risk Factor....Pages 658-664
Vasoactive Agents and Postprandial Chylomicrons as Risk Factors in Atherogenesis....Pages 664-670
Unexplained Variability in Extent of Atherosclerosis in Homogeneous Human Populations....Pages 671-674
Abstract....Pages 675-675
Diet and Coronary Heart Disease — Primary Prevention Trials....Pages 676-679
Attempts at Primary and Secondary Prevention of Coronary Heart Disease....Pages 680-686
Intervention Trial for Secondary CV Prevention in Primary Atherogenous Hyperlipidemias....Pages 686-690
The Multiple Risk Factor Intervention Trial (MRFIT)....Pages 690-692
Back Matter....Pages 693-800
