Aspergillosis: from diagnosis to prevention

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Introduction....Pages 3-5
Differences and Similarities Amongst Pathogenic Aspergillus Species....Pages 7-32
Immunology of Aspergillus and Aspergillosis: The Story So Far....Pages 33-52
The Importance of Conventional Methods: Microscopy and Culture....Pages 54-73
Molecular Methods for Identification of Aspergillus Species....Pages 75-85
The Pathology of Aspergillus Infection....Pages 87-104
Galactomannan Testing....Pages 105-124
β-D-Glucan Testing....Pages 125-133
Polymerase Chain Reaction (PCR)-Based Tests....Pages 135-157
Aspergillus Precipitins and Serology....Pages 159-169
Specific IgE Testing (RAST)....Pages 171-176
Molecular Typing of Aspergillus fumigatus Isolates....Pages 177-191
Antifungal Susceptibility Tests of Aspergillus Species....Pages 193-215
Antifungal Therapeutic Drug Monitoring for Invasive Aspergillosis....Pages 217-228
Azoles....Pages 230-262
Echinocandins....Pages 263-279
Polyene Antifungal Agents....Pages 281-305
5-Flucytosine....Pages 307-315
Terbinafine....Pages 317-325
Front Matter....Pages 327-327
Epidemiology of Invasive Pulmonary Aspergillosis....Pages 329-344
Front Matter....Pages 327-327
Pathogenesis of Invasive Pulmonary Aspergillosis....Pages 345-379
Clinical Manifestations of Invasive Pulmonary Aspergillosis....Pages 381-389
Diagnosing Aspergillosis: The Role of Invasive Diagnostic Interventions....Pages 391-405
Optimising the Use of Non-invasive Tests: From Blood to Radiology....Pages 407-422
Defining Invasive Aspergillosis: What the Revised EORTC/MSG Definitions Have in Store....Pages 423-435
Treatment of Invasive Pulmonary Aspergillosis....Pages 437-448
Antifungal Prophylaxis in Haematology....Pages 449-457
Invasive Aspergillosis in Paediatric Patients....Pages 460-483
Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient....Pages 485-503
Aspergillosis in Surgical Patients....Pages 505-525
Invasive Aspergillosis in Chronic Granulomatous Disease....Pages 527-543
Aspergillosis in Drug Addicts....Pages 545-558
Invasive Aspergillosis and HIV Infection....Pages 559-566
Invasive Pulmonary Aspergillosis in Solid Organ Transplant Recipients....Pages 567-581
Front Matter....Pages 583-583
Chronic Cavitary Pulmonary Aspergillosis and Fungal Balls....Pages 585-620
Pathogenesis of Chronic Cavitary Pulmonary Aspergillosis: The Importance of the Host Immune System....Pages 621-642
Current Surgical Strategies for Chronic Cavitary Pulmonary Aspergillosis....Pages 643-651
Front Matter....Pages 655-655
Overview of Aspergillus Allergens....Pages 655-669
Epidemiology of Allergic Bronchopulmonary Aspergillosis....Pages 671-688
ABPA as an Occupational Disease....Pages 689-693
Front Matter....Pages 655-655
Pathogenesis of ABPA....Pages 695-706
Clinical Manifestations and Natural History of Allergic Bronchopulmonary Aspergillosis....Pages 707-724
How to Diagnose Allergic Bronchopulmonary Aspergillosis....Pages 725-745
The Treatment of ABPA....Pages 747-759
Severe Asthma with Fungal Sensitisation (SAFS)....Pages 761-775
Front Matter....Pages 777-777
Aspergillus Sinusitis....Pages 779-814
Front Matter....Pages 815-815
Aspergillus Overlap Syndromes....Pages 817-831
Front Matter....Pages 833-833
Cerebral Aspergillus Infections and Meningitis....Pages 835-852
Osteoarticular and Epidural Infections....Pages 853-862
Aspergillosis of the Digestive Tract....Pages 863-887
Cardiac Aspergillosis....Pages 889-903
Aspergillus Thyroiditis....Pages 905-911
Aspergillus Endophthalmitis....Pages 913-929
Urinary Tract Infections Caused by Aspergillus Species....Pages 931-937
Cutaneous and Wound Aspergillosis....Pages 939-959
Onychomycosis Due to Aspergillus Species....Pages 961-971
Aspergillus Keratitis....Pages 973-998
Aspergillus Otitis....Pages 999-1006
How to Diagnose Allergic Bronchopulmonary Aspergillosis....Pages E1-E23
Back Matter....Pages 1-21