Antibiotic Development and Resistance

Contents......Page 6
Introduction......Page 8
1.A Global Perspective on Bacterial Infections, Antibiotic Usage, and the Antibiotic Resistance Problem......Page 16
2.Target Alterations Mediating Antibiotic Resistance......Page 41
3. Evolution of Multiple Antibiotic Resistance by Acquisition of New Genes......Page 59
4.Adaptive Resistance to Antibiotics......Page 77
5. \rEfflux Mechanisms: Molecular and Clinical Aspects......Page 91
6. Bacterial Genetics and Antibiotic Resistance Dissemination......Page 123
7. Mutator Bacteria and Resistance Development......Page 143
8.Low-level Antibiotic Resistance......Page 158
9.Possible Impact on Antibiotic Resistance in Human Pathogens Due to Agricultural Use ofAntibiotics......Page 184
10.Fitness and Virulence of Antibiotic Resistant Bacteria......Page 204
11.Evolutionary Consequences and Costs of Plasmid-Borne Resistance to Antibiotics......Page 215
12.Structural Insights into AntibioticTarget Interactions......Page 236
13.New Targets and Strategies for Identification of Novel Classes of Antibiotics......Page 257
14.Peptide Antibiotics......Page 272
15.Molecular Genetic and Combinatorial Biology Approaches to Produce Novel Antibiotics......Page 301
Index......Page 338