Amyloidosis

Front Matter....Pages I-XVI
Front Matter....Pages 1-1
General Introduction and a Brief History of Amyloidosis....Pages 3-19
Front Matter....Pages 21-21
Amyloid Proteins....Pages 23-34
Carbohydrate-Containing AL Proteins....Pages 35-37
Endocrine Amyloid Fibril Proteins....Pages 39-42
Amyloid P-Component: Structure and Properties....Pages 43-49
A Brief Review of the Ultrastructure of Amyloid....Pages 51-57
Front Matter....Pages 59-59
Clinical Evaluation of AA and AL Amyloid Disease....Pages 61-72
Cardiac Involvement in Amyloidosis....Pages 73-82
Hemodialysis-Associated Amyloid of β 2 -Microglobulin Nature....Pages 83-89
Amyloid P-Component: Clinical Implications....Pages 91-98
Front Matter....Pages 99-99
Amyloid Protein AA and its Precursor, The Acute Phase Protein(s) ApoSAA: A Perspective....Pages 101-106
Sites and Regulation of Biosynthesis of SAA....Pages 107-113
Serum Amyloid A Protein in Plasma: Characteristics of Acute Phase HDL....Pages 115-125
Correlation Between Sequence Variability and Structure Prediction in AA Proteins....Pages 127-133
Gene Structure of a Human Serum Amyloid A Protein and Comparison with Amyloid A....Pages 135-139
Structure and Expression of Murine Serum Amyloid A Protein Genes: Implications for Amyloidogenesis....Pages 141-148
Amyloidogenic Proteins in Human Central Nervous System Diseases....Pages 149-157
Structure of the Alzheimer Paired Helical Filament....Pages 159-167
The Significance of Non-Protein AA Material in Water-Soluble Bovine AA-Amyloid Fibrils....Pages 169-175
Fibril Derived Amyloid Enhancing Factor (FAEF) in Hamster: Evidence for a Close Relationship between AEF and AA-Amyloid Fibrils....Pages 177-182
Front Matter....Pages 183-183
The Hereditary Amyloidoses....Pages 185-193
Familial Amyloidotic Polyneuropathies....Pages 195-218
Biochemical and Genetic Characterization of a Variant Transthyretin Causing Familial Amyloidotic Polyneuropathy....Pages 219-223
Front Matter....Pages 225-225
The Nature and Pathogenesis of the Amyloid Deposits in Alzheimer’s Disease....Pages 227-242
Biochemistry of Cerebral Amyloid in Alzheimer’s Disease, The Unconventional Slow Virus Diseases and Icelandic Cerebrovascular Amyloidosis....Pages 243-253
Amyloid of the Islets of Langerhans and its Connection with Diabetes Mellitus....Pages 255-259
Senile Amyloid Affecting the Heart....Pages 261-265
Amyloid Arthropathy....Pages 267-270
Peripheral Angiopathy....Pages 271-282
Animal Models....Pages 283-291
Front Matter....Pages 293-293
Pathology of Experimental Amyloidosis....Pages 295-300
What Factors are Necessary for the Induction of AA Amyloidosis?....Pages 301-310
Amyloidogenic Proteins in Mice....Pages 311-318
Sites of SAA/AA Synthesis....Pages 319-327
The Role of the Macrophage Phagocytic System (MPS) in the Development of Secondary Amyloidosis....Pages 329-336
SAA Kinetics in Animals....Pages 337-340
Amyloid and Female Protein: Sex-Related Occurrence in the Syrian Hamster....Pages 341-346
Endocrine Amyloid in Animals....Pages 347-349
Dietary Treatment during the Induction and Resorption Phases of Experimental Amyloidosis....Pages 351-354
Front Matter....Pages 355-355
Future Directions in Amyloid Research....Pages 357-363
Back Matter....Pages 365-378