36th Hemophilia Symposium Hamburg 2005: Epidemiology; Hemophilia Therapy - Management of Bleedings and Inhibitors; Orthopedic Treatment in Hemophiliacs; ... Pediatric Hemostaseology; Free Lectures

Front Matter....Pages I-XXXIV
Front Matter....Pages 1-1
HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2004/2005 Survey)....Pages 3-14
Development of the German Hemophilia Register....Pages 15-15
National Hemophilia Registry - Source of Information about the Quality of Hemophilia Medical Care in a Developing Country....Pages 16-20
Front Matter....Pages 21-21
Regulation of Factor VIII Life-Cycle by Receptors from LDL Receptor Superfamily....Pages 23-33
Update of the Inhibitor-Immunology-Study....Pages 34-39
Therapy of Acquired Hemophilia - Immunoadsorption and Rituximab Treatment for Immunosuppression and Substitution of Coagulation Factors....Pages 40-47
Front Matter....Pages 49-49
Osteoporosis and Hemophilia - Is there a Correlation and Is there a Problem?....Pages 51-53
Orthopedic Evaluation of the Lower Extremity in 249 Children: A Multicenter Trial....Pages 54-56
Simultaneous Bilateral Total Knee Arthroplasty in Hemophilic Arthopathy....Pages 57-62
Alternative Therapy such as the Acupuncture of the Skull for Hemophilic Arthropathy....Pages 63-66
Endoprosthetics of Large Joints in Patients Infected with HIV....Pages 67-67
Front Matter....Pages 69-69
Factor VIII Methods: Which Assay Principle for which Indication?....Pages 71-74
Global ECAT Survey on Factor VIII Inhibitor Testing: Results of an Inter-Laboratory Pilot Study....Pages 75-77
A Practical Concept for Pre-Operative Identification and Improved Management of Patients at Risk for Bleeding....Pages 78-89
Front Matter....Pages 91-91
Intravascular Tissue Factor in Cord vs Adult Whole Blood....Pages 93-95
Perioperative Coagulation Screening in Children - Reasons and Results....Pages 96-100
Thrombin Generation in Children....Pages 101-107
Front Matter....Pages 109-109
Working-Group of the German Hemophilia Assistants - History, Purpose and Goals....Pages 111-113
The Endogenous Thrombin Potential as a New Parameter for the Peri-Operative Monitoring in Conjunction with Endo-Prosthetic Supply due to Hemophilic Arthropathy....Pages 114-117
Identification of Inhibitor Epitopes in Acquired Hemophilia by Phage Display....Pages 118-128
Front Matter....Pages 109-109
Spectrum of Molecular Defects and Mutation Detection Rate in Patients with Mild and Moderate Hemophilia A....Pages 129-132
Recombinant Factor VIIa for Major Surgery in Severe Factor XI Deficiency: Pharmacodynamic Monitoring Using Thromboelastometry....Pages 133-136
Front Matter....Pages 137-137
Establishment of a Web-Based Documentation System for Quality Assurance of Hemophilia Treatment in Mecklenburg/Western Pomeranian: a Pilot Study....Pages 139-139
Successful Angiographic Embolization of Recurrent Elbow Joint Bleeds in one Patient with Severe Hemophilia A....Pages 140-143
Evaluation of Thrombotic Events in Hemophiliacs Undergoing Major Orthopedic Surgery Without Thrombosis Prophylaxis....Pages 144-146
Motivating Patients and Parents to Document Treatment Correctly....Pages 147-149
Fit for Life Competition: Everyone’s a Winner....Pages 150-152
Blood Borne Infections in Hemophiliacs in a Developing Country. A Single Center Experience....Pages 153-158
Hemophilia Center Frankfurt - Twinning Center for Nairobi/Kenya....Pages 159-160
Economic Evaluation of Orthopedic and Surgical Interventions in Hemophiliacs - Not Only Direct Medical Costs Matter....Pages 161-167
The Occurrence of Factor VIII Inhibitor in a Patient with Mild Hemophilia A - During Treatment with Interferon for Chronic Hepatitis C....Pages 171-172
Severe Hemophilia A Patient with High-Titer Inhibitor, use of TGA in the Monitoring of Bypassing Therapy....Pages 173-174
EUREKA - an European Registry for Orthopedic Surgery in Hemophiliacs with Inhibitors....Pages 175-175
Double Balloon Enteroscopy (DBE) with Argon Plasma Laser Coagulation (APC) for a Patient with Heyde’s Syndrome....Pages 179-183
Successful Liver Transplantation in a Patient with Anti-Thrombocyte Antibodies and Severe Hemophilia A....Pages 184-186
Peri- and Postoperative Course of 95 Patients with von-Willebrand’s Disease....Pages 187-189
Pregnancy in a Patient with Congenital Antithrombin Deficiency....Pages 190-194
Successful Inhibitor-Elimination with Rituximab in Acquired Hemophilia A and a Patient with a Carrier Status for Hemophilia A: Two Case Reports....Pages 195-199
An Interesting Family Case of von-Willebrand-Syndrome....Pages 200-200
Clinical Manifestations of Dysfibrinogenemia in Relation to the Fibrinogen Gene Mutation....Pages 201-202
Front Matter....Pages 137-137
Thrombin Generation in a Hemophilic Newborn....Pages 203-209
Rapid and Sensitive Detection of Heterozygous Deletions of one or more Exons in Hemophilia A Females by Multiplex PCR and DHPLC Technique....Pages 213-216
Molecular Genetic Analysis in Patients with Inherited Factor V Deficiency....Pages 217-219
Expression Analysis of C1-Inhibitor Mutants Confirms Causality of Missense Mutations for Hereditary Angioedema....Pages 220-223
Expression of the γ-Glutamyl Carboxylase (GGCX) Containing the Arg485Pro Mutation Found in two Unrelated VKCFD1 Patients....Pages 224-228
Concentration of Soluble Endothelial Protein C Receptor (EPCR) in Plasma in Relation to Age, Sex, BMI and Hemostasis Parameters....Pages 229-234
Thrombin Generation is Age-Dependent in Children as well as in Adults....Pages 235-239
Effects of PFA-100 in Preoperative Screening for von Willebrand Disease in 310 Patients....Pages 240-242
Control of Aspirin Effect in Chronic Cardiovascular Patients Using two Whole Blood Platelet Function Assays: PFA-100 and Multiple Electrode Aggregometry....Pages 243-251
Difficulties in the Interpretation of the Term »Patient-Related« in the Scope of the Introduction of a Remuneration of Additional Payments According to the OPS....Pages 255-256
Factor VIII as Positive Regulator of Activated Platelets....Pages 257-262
Characterization of Three Novel Mutations in the Sodium Binding Site of Coagulation Factor X....Pages 263-271
Characterization of a Mutation in the 5′ Flanking Region and a Novel IVS7 Splice site Mutation in a Patient with Severe FVII Deficiency....Pages 272-278
On the Molecular Basis of Warfarin Resistance in Rats....Pages 279-283
Influence of Factor V HR2 on Endogenous Thrombin Potential and Clinical Phenotype in Factor VII Deficiency....Pages 284-290
Splice Site Mutations Effect on the F8 mRNA Splicing....Pages 291-294
Species-Specific Variation of VKORC1-Activity and Resistance to Warfarin....Pages 295-297
Various Missense Mutations in the Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Cause Hereditary Coumarin Resistance....Pages 298-301
Establishment of an International Registry of Patients with Congenital FXIII Deficiency....Pages 302-304
The Impact of Freezing of Plasma Samples, AB0 Blood Group and Acute-Phase Reaction on Detecting Mild Factor VIII Deficiency and Increased Factor VIII Levels as a Risk Factor for Venous Thromboembolism....Pages 305-309
Front Matter....Pages 137-137
Thrombin Generation in Severely Obese Children....Pages 310-314
Back Matter....Pages 315-320