Vitamin D: Molecular Biology, Physiology, and Clinical Applications

Front Matter....Pages i-xii
Evolution, Biologic Functions, and Recommended Dietary Allowances for Vitamin D....Pages 1-16
Photobiology of Vitamin D....Pages 17-37
Functional Metabolism and Molecular Biology of Vitamin D Action....Pages 39-56
Metabolism and Catabolism of Vitamin D, Its Metabolites, and Clinically Relevant Analogs....Pages 57-84
The Enzymes Responsible for Metabolizing Vitamin D....Pages 85-99
The Vitamin D Binding Protein and Its Clinical Significance....Pages 101-107
Molecular Biology of the Vitamin D Receptor....Pages 109-128
Vitamin D Receptor Translocation....Pages 129-145
Molecular Recognition and Structure-Activity Relations in Vitamin D-Binding Protein and Vitamin D Receptor....Pages 147-162
Mechanism of Action of 1,25-Dihydroxyvitamin D 3 on Intestinal Calcium Absorption and Renal Calcium Transport....Pages 163-173
Biologic and Molecular Effects of Vitamin D on Bone....Pages 175-193
Nongenomic Rapid Effects of Vitamin D....Pages 195-205
Noncalcemic Actions of 1,25-Dihydroxyvitamin D 3 and Clinical Implications....Pages 207-216
Regulation of Parathyroid Hormone Gene Expression and Secretion by Vitamin D....Pages 217-237
Vitamin D Assays and Their Clinical Utility....Pages 239-271
Rickets and Vitamin D Deficiency....Pages 273-286
Vitamin D and Bone Health in Adults and the Elderly....Pages 287-305
Inherited Defects of Vitamin D Metabolism....Pages 307-316
Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets....Pages 317-336
Extrarenal Production of 1,25-Dihydroxyvitamin D and Clinical Implications....Pages 337-356
Clinical Utility of 1,25-Dihydroxyvitamin D 3 and Its Analogs for the Treatment of Psoriasis and Other Skin Diseases....Pages 357-373
Epidemiology of Cancer Risk and Vitamin D....Pages 375-391
Chemotherapeutic and Chemopreventive Actions of Vitamin D 3 Metabolites and Analogs....Pages 393-409
Vitamin D and Breast Cancer....Pages 411-429
Anitcancer Activity of Vitamin D Analogs....Pages 431-445
Back Matter....Pages 447-458