Viruses and Human Disease

Viruses and Human Disease......Page 4
Copyright Page......Page 5
Contents......Page 6
Preface......Page 8
Introduction......Page 10
Classification of Viruses......Page 14
An Overview of the Replication Cycle of Viruses......Page 17
Effects of Virus Infection on the Host Cell......Page 36
Epidemiology: The Spread of Viruses from Person to Person......Page 38
Further Reading......Page 39
Helical Symmetry......Page 42
Icosahedral Symmetry......Page 43
Enveloped Viruses......Page 52
Assembly of Virions......Page 61
Stability of Virions......Page 64
Further Reading......Page 65
Introduction......Page 66
Family Picornaviridae......Page 67
Family Caliciviridae......Page 80
Family Astroviridae......Page 83
Family Togaviridae......Page 85
Family Flaviviridae......Page 94
Family Coronaviridae......Page 109
Family Arteriviridae......Page 112
The Plus-Strand RNA Viruses of Plants......Page 113
Origin and Evolution of Plus-Strand RNA Viruses......Page 114
Viruses That Contain Double-Stranded RNA: Family Reoviridae......Page 117
Further Reading......Page 131
Overview of the Minus-Strand RNA Viruses......Page 132
Family Rhabdoviridae......Page 135
Family Paramyxoviridae......Page 141
Family Filoviridae......Page 153
Family Bornaviridae......Page 155
Family Orthomyxoviridae......Page 156
Family Bunyaviridae......Page 165
Family Arenaviridae......Page 171
Further Reading......Page 177
Introduction......Page 180
Family Retroviridae......Page 181
Family Hepadnaviridae......Page 219
Further Reading......Page 227
Introduction......Page 230
Family Poxviridae......Page 232
Family Herpesviridae......Page 243
Family Adenoviridae......Page 261
Family Polyomaviridae......Page 268
Family Papillomaviridae......Page 274
Family Parvoviridae......Page 279
Further Reading......Page 285
Defective Interfering Viruses......Page 288
Satellites and Satellite Viruses......Page 292
Hepatitis s......Page 293
Prions and Prion Diseases......Page 300
Further Reading......Page 311
Adaptive Immune System......Page 312
Innate Immune System......Page 332
Viral Counterdefenses......Page 341
Interactions of Viruses with Their Hosts......Page 354
Further Reading......Page 355
Virus Vector Systems......Page 356
Use of Viruses as Expression Vectors......Page 366
Further Reading......Page 374
Appendix A. References for Figures......Page 376
Appendix B. References for Tables......Page 382
Index......Page 384