Veterinary Pharmacology and Toxicology

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Perinatal pharmacology in ruminant models....Pages 3-22
Placental transfer of drugs in ruminant animals....Pages 23-37
Drug disposition in the fetus....Pages 39-48
Drug disposition in the newborn....Pages 49-55
Postnatal development of renal function in goats....Pages 57-62
Developmental patterns of penicillin G excretion....Pages 63-72
Drug effects during development and carcinogenicity....Pages 73-81
APPENDIX....Pages 82-92
Chemical induced teratogenesis....Pages 93-97
Levamisole as an immunomodulator in the prevention of neonatal disease....Pages 99-103
Development and prophylaxis of anaemia in calves and lambs....Pages 105-113
Oral fluid therapy: some concepts on osmolality, electrolytes and energy....Pages 115-130
Front Matter....Pages 131-131
Drug bioavailability in the developing ruminant....Pages 133-140
Oral antibacterial therapy in pre- and postweaning calves....Pages 141-149
Influence of ruminant gastrointestinal physiology on the pharmacokinetics of drugs in dosage forms administered orally....Pages 151-163
Ruminal influences on drug action....Pages 165-181
Recent developments in the treatment of metabolic diseases....Pages 183-191
Drug excretion by the mammary gland....Pages 193-202
Pharmacology of uterine motility and relaxation....Pages 203-211
New prostaglandins: present studies and future....Pages 213-220
Front Matter....Pages 131-131
Worm diseases: economic aspects of anthelmintic treatment....Pages 221-224
Pharmacological basis of the treatment of helminth in cattle....Pages 225-233
Pharmacokinetics of albendazole, fenbendazole and oxfendazole....Pages 235-240
Pharmacokinetics of levamisole in goats and pigs....Pages 241-244
Appendix....Pages 245-245
The prophylactic activity of imidocarb against tick-transmitted parasitic infections....Pages 247-254
Front Matter....Pages 255-255
The distribution and function of histamine receptors....Pages 257-262
Serotonin and S 2 antagonists in veterinary medicine....Pages 263-281
Dopaminergic control of gastrointestinal motility....Pages 283-298
Vomiting and antiemetics in small animal practice....Pages 299-305
Diarrhoea and antidiarrhoeal drugs....Pages 307-320
Pharmacology and comparative toxicology of non-steroidal anti-inflammatory agents....Pages 321-331
Clinical pharmacokinetic studies of digoxin and digitoxin in the dog....Pages 333-339
Influence of anaesthetics and ancillary agents on cardiovascular and respiratory systems in the horse....Pages 341-351
Steroidal anti-inflammatory agents in the horse: pharmacokinetics and action on the adrenal gland....Pages 353-366
Spasmolytic analgesic drugs and small intestinal function in the horse....Pages 367-370
Physiological, pharmacological and therapeutic aspects of some gastrointestinal disorders in the horse....Pages 371-380
Pharmacological control of reproductive mechanisms in the equine female....Pages 381-394
Front Matter....Pages 395-395
Clinical utility and limitations of pharmacokinetics....Pages 397-414
Pharmacological approach of drugs used in coronary insufficiency and cerebrovascular pathology....Pages 415-418
Front Matter....Pages 395-395
Appendix....Pages 419-419
Fever, trace metals and disease. The effect of antipyretic agents....Pages 421-427
Efficacy of penicillin against Streptococcus zooepidemicus . Infection model in the horse....Pages 429-435
Receptor binding methods: application to the study of cyclopyrrolones, a new family of minor tranquillizers....Pages 437-449
Multiplicity of kappa opiate sites in the central nervous system....Pages 451-463
Hepatocyte cultures as a research tool in pharmacology and toxicology....Pages 465-478
Metabolic radical formation from halothane and enflurane and its modification by enzyme induction and inhibition....Pages 479-484
Anaesthesia in pharmacological research....Pages 485-500
Evaluation of analgesic drug combinations....Pages 501-522
Enzyme induction and inhibition....Pages 523-537
Rapid induction of cirrhosis in the liver. A model of hepatic disease....Pages 539-552
Behavioural analysis of drug action....Pages 553-563
Experimental models for respiratory diseases of ruminants and of swine....Pages 565-592
Front Matter....Pages 593-593
Environmental pollution: the animal as source, indicator and transmitter....Pages 595-608
Residues of drugs and pesticides in milk....Pages 609-623
Mycotoxin residue problem and human health hazard....Pages 625-640
Residues of xenobiotics in animals, milk, and environment in the light of a 13 year surveillance....Pages 641-645
Persistence in milk of active antimicrobial intramammary substances....Pages 647-657
Evaluation of drug residues in animal tissues....Pages 659-670
Photosensitization in ruminants: porphyrins and phylloerythrin....Pages 671-680
Front Matter....Pages 593-593
Fluorosis in the sheep: new data....Pages 681-690
Chloramphenicol-propylene glycol toxicity following constant intravenous infusion in horses....Pages 691-696
Heavy metal intoxications in horses....Pages 697-714
Evaluation of subclinical lead poisoning in dairy cattle....Pages 715-724
Poisoning of animals in the Los Angeles area with pesticides (1981)....Pages 725-731
Toxicological field data in ruminants....Pages 733-736
Adverse drug reactions and interactions (1979–1981)....Pages 737-744
Front Matter....Pages 745-748
Medicated feed in French Legislation and European Economic Community....Pages 749-751
Medicated feed: problems and solutions....Pages 752-757
Medicated feed manufacturing....Pages 758-759
Animal drugs and the evaluation of residues in milk and meat....Pages 760-763
Drugs for prevention or treatment of internal parasites in farm animals. Particular cases of medicated feed....Pages 764-767
Virginiamycin activity and safety in ruminants....Pages 768-770
The use of monensin in cattle: effectiveness and safety to the consumer....Pages 771-773
Effect of lasalocid sodium on digestion in sheep....Pages 774-778
Evaluation of the efficacy of lasalocid sodium on the fattening of steers....Pages 779-781
Salinomycin, a new polyether antibiotic for fattening cattle and lambs....Pages 782-785
Salinomycin activity in ruminants....Pages 786-794
Front Matter....Pages 795-797
Detomidine hydrochloride. A novel imidazole-type sedative analgesic....Pages 798-799
The cardiovascular effects of ketamine, thiopentone and methohexitone after xylazine premedication in horses....Pages 800-802
Front Matter....Pages 795-797
Study on interactions between chloramphenicol and intravenous anaesthetics....Pages 803-803
The neuromuscular blocking action of a new muscle relaxant atracurium in the dog....Pages 804-805
Haemodynamic effects of methoxyflurane in dogs....Pages 806-807
Afferent inputs to mammalian spinal neurons: studies with anaesthetic and analgesic agents....Pages 808-810
Evaluation of etomidate and fentanyl in dog anaesthesia....Pages 811-812
Interactions between dissociative anaesthetics and neurotransmitter receptors in the mammalian central nervous system....Pages 813-816
Clinical pharmacology of ketamine in the pig....Pages 817-819
The use of a combination of xylazine and ketamine in calves....Pages 820-822
E.e.g. frequency analysis of barbiturate and ketamine anaesthesia....Pages 823-824
Back Matter....Pages 825-838