Tumor Cell Differentiation: Biology and Pharmacology

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Hematopoietic Growth and Differentiation Factors and the Reversal of Malignancy....Pages 3-27
G-CSF as a Differentiation-Inducing Agent in Normal and Leukemic Myelopoiesis....Pages 29-49
Induction of Differentiation in Myeloid Leukemic Cells and the Differentiation Inducing Factor (DIF)....Pages 51-59
Proliferation and Differentiation of Human Leukemic Cells in Culture....Pages 61-69
Infrequent Phenotypes of Clonogenic Cells in AML: Evidence for Abnormal Differentiation and Possibilities for Detecting Minimal Disease?....Pages 71-78
Studies of Gene Expression During Granulocyte Maturation....Pages 79-103
Granulocytes Obtained from HL-60 Cells by Retinoic Acid Treatment Behave Abnormally in Hematopoietic Regulation — Possible Consequences for Differentiation Induction Treatment of Leukemia....Pages 105-113
 Beta -Adrenergic Receptors of Normal, Transformed and Immature Human Leucocytes....Pages 115-120
Front Matter....Pages 121-121
Molecular and Cellular Aspects of Embryonal Carcinoma Cell Differentiation....Pages 123-136
Interaction of 1,25 Dihydroxyvitamin D 3 with Normal and Abnormal Hematopoiesis....Pages 137-157
Retinoic Acid-Induced Differentiation of HL-60: Studies in Vitro and in Vivo....Pages 159-181
Plasma Membrane Signals Linked to the Retinoic Acid-Induced Differentiation of HL-60 Cells....Pages 183-194
Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?....Pages 195-203
Therapeutic Effects of Low-Dose Cytosine Arabinoside, α-Interferon, 1,25-Dihydroxyvitamin D 3 and Retinoic Acid in Myelodysplastic Syndromes and Acute Leukemia....Pages 205-212
Front Matter....Pages 213-213
Sequence-Specific DNA Methylation: Promoter Inactivation and Release of the Expression Block....Pages 215-230
Induction of Differentiation of 3T3-L1 Fibroblasts to Adipocytes by 3-Deazaadenosine and Insulin....Pages 231-240
Differentiation of Human Leukemia Cells by Nucleoside Analogues....Pages 241-249
Effects of Purine Nucleosides on Differentiation in Lymphohematopoietic Stem Cell Leukemia....Pages 251-258
Effect of Methylation Inhibitors on Phorbol Ester Induced Differentiation of HL-60 Promyelocytic Leukemia Cells....Pages 259-267
Perturbation of Homocysteine Metabolism by Pharmacological Agents in Experimental and Clinical Use....Pages 269-278
Front Matter....Pages 213-213
C-8-Substituted Guanosine Analogues are Novel Immunostimulants and Differentiating Agents for Neonatal, Normal and X-Linked Immune Defective ( xid ) B Lymphocytes....Pages 279-287
Front Matter....Pages 289-289
Differentiation as a Mechanism for Control of Malignancy in Human Cell Hybrids....Pages 291-304
Interaction Between Brain Tissue and Malignant Glioma Cells in Organ Culture....Pages 305-315
Tumor Promoter-Mediated Modulation of Cell Differentiation and Communication: The Phorbol Ester — Oncogene Connection....Pages 317-339
Back Matter....Pages 341-347