Trace Elements in Clinical Medicine: Proceedings of the Second Meeting of the International Society for Trace Element Research in Humans (ISTERH) August 28–September 1, 1989, Tokyo

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Discovery of Human Zinc Deficiency and Marginal Deficiency of Zinc....Pages 3-11
Front Matter....Pages 13-13
Zinc in Taste and Smell Disorders....Pages 15-37
Brain Aging and Trace Elements in Human: Clues into the Pathogenesis of Alzheimer’s Disease....Pages 39-46
Zinc in Brain Development and Function....Pages 47-52
Zinc Binding Peptides from Rat Brain....Pages 53-56
Role of Zinc in the Peripheral Nervous System....Pages 57-62
Front Matter....Pages 63-63
Experimental and Epidemiological Studies on the Relation of Trace Elements in the Pathogenesis and Prevention of Cardiovascular Diseases....Pages 65-75
Front Matter....Pages 77-77
Alcohol, Trace Elements, and Liver Dysfunction....Pages 79-83
Regional Variations of Eight Trace Elements in Normal Human Liver....Pages 85-88
The Role of Copper and Zinc as Pathogenic Factors in Liver Disease....Pages 89-92
Zinc and Gastrointestinal Diseases....Pages 93-97
Pathophysiological Significance of an Oral Zinc Tolerance Test in Patients with Chronic Hepatic Diseases....Pages 99-108
Zinc Absorption in Normal Subjects and in Gastrointestinal Diseases....Pages 109-112
The Relationship Between Plasma Iron Tolerance Curves and Fractional Intestinal Absorption of Iron....Pages 113-116
Regulators of Iron Absorption in the Small Intestine....Pages 117-121
Front Matter....Pages 123-123
Aluminum Intoxication....Pages 125-128
Search for the Unknown Trace Element Abnormalities in Uremia....Pages 129-132
Front Matter....Pages 133-133
Selenium and Cancer....Pages 135-140
Kinetics of Trace Elements in Cancer Patients....Pages 141-148
Trace Elements in Cancer Diagnosis....Pages 149-154
Front Matter....Pages 133-133
Trace Elements in Cancer Therapy....Pages 155-161
Front Matter....Pages 163-163
Modulation of the Immune Response by Trace Elements....Pages 165-171
Trace Element Regulation of Immunity and Infection....Pages 173-175
Zinc and Thymulin....Pages 177-182
Front Matter....Pages 183-183
Effects of Exercise, Physical Trauma, and High Sugar Intake on Chromium, Copper, and Zinc Metabolism....Pages 185-191
Zinc: The Role and It’s Implication in Clinical Surgery....Pages 193-199
Front Matter....Pages 201-201
Trace Elements in Total Parenteral Nutrition....Pages 203-225
Effect of Zinc Redistribution on Wound Healing during Total Parenteral Nutrition in Rats....Pages 227-230
Clinical Study on Zinc Deficiency Receiving Total Parenteral Nutrition....Pages 231-234
Molecular and Biochemical Aspects of Selenium Deficiency....Pages 235-237
Platelet Glutathione Peroxidase Activity in Long-term Total Parenteral Nutrition with/without Selenium Supplementation....Pages 239-242
Cardiomyopathy and Selenium Deficiency in a Caucasian Adolescent....Pages 243-245
Front Matter....Pages 247-247
Nephrotoxicities of Gold and Cisplatinum....Pages 249-254
Drug-Induced Taste Disorder: Due to Zinc Chelation?....Pages 255-260
Antiarthritic, Antiulcer, and Analgesic Activities of Copper Complexes....Pages 261-268
Front Matter....Pages 269-269
Genetic Disorders of Copper Transport: Menkes’ Disease, Occipital Horn Syndrome, and Wilson’s Disease....Pages 271-276
Prevention Possibility for Brain Dysfunction in Menkes’ Disease by Maternal Administration of Trace Elements....Pages 277-281
Human and Canine Inherited Copper Toxicosis: Copper Balance Regulation and Molecular Genetics of Its Impairment....Pages 283-287
Front Matter....Pages 289-289
Finger-Loop Domains and Trace Metals....Pages 291-298
Construction of Mouse Glutathione Peroxidase Gene and Its Expression....Pages 299-306
Front Matter....Pages 289-289
The Role of Natural Opal Suppressor tRNA in Incorporation of Selenium into Glutathione Peroxidase....Pages 307-314
Transcriptional Activation of Human and Yeast Metallothionein Genes by Heavy Metal Ions....Pages 315-322
Front Matter....Pages 323-323
Recommended Dietary Intakes of Trace Elements: Some Observations on Their Definition and Interpretation in Comparison with Actual Levels of Dietary Intake....Pages 325-331
The Problems of Nutrition Requirements of Trace Elements: General Comments....Pages 333-337
Trace Element Requirements and Dietary Intake Recommendations: With Specific Reference to the Third World....Pages 339-348
Biochemical Characterization of Selenium Deficiency in China....Pages 349-352
Ultratrace Elements: An Update....Pages 353-360
The Influence of the Ultra Trace Element Deficiency (Mo, Ni, As, Cd, V) on Growth, Reproduction Performance and Life Expectancy....Pages 361-376
Front Matter....Pages 377-377
Manganese as a Potential Modulator of Second Messenger Pathways....Pages 379-383
Metabolism of Trace Metals in Ascorbic Acid Deficiency: With Special Regard to Zinc Metabolism....Pages 385-392
Front Matter....Pages 393-393
Metallothionein: Biochemistry and Spatial Structure....Pages 396-403
Metallothionein and Zinc Deficiency....Pages 405-411
Synthesis and Properties of a Selenium Analogue of Metallothionein....Pages 413-419
Transport of Copper....Pages 421-424
Front Matter....Pages 425-425
ICP-MS-Application to Biological Samples....Pages 427-436
Role of Reference Materials for Validation of Analytical Data in Trace Element Analysis of Biological Materials....Pages 437-442
A Guideline for Application of Neutron Activation Analysis to Biological and Medical Samples....Pages 443-450
Summary of New Analytical Techniques and General Discussion....Pages 451-456
Front Matter....Pages 457-457
Aluminum Toxicity in Humans....Pages 459-464
Methylmercury Toxicity....Pages 465-470
Front Matter....Pages 457-457
Advances in the Toxicology of Inorganic Mercury....Pages 471-477
Current Topics on the Toxicology of Inorganic Lead....Pages 479-485
Cadmium Accumulation in Human Tissues: Relationship to Development of Toxic Effects....Pages 487-492
Factors Aggravating Cadmium Health Effects in Old Animals....Pages 493-500
Back Matter....Pages 501-504