Toxicology and Experimental Models. Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981

Content: 
ADVANCES IN PHARMACOLOGY AND THERAPEUTICS II, Page ii
Front Matter, Page iii
Copyright, Page iv
Introduction, Page ix, Hiroshi YOSHIDA, Yashiro HAGIHARA, Setsuro EBASHI
The Rational Interpretation of Species and Strain Differences for the Prediction of Risk to Man Introduction, Pages 3-6, D.S. Davies
The Potential Value of Immunopathology in Toxicity Studies, Pages 7-16, E.D. Wachsmuth
Lessons from Studies in Animals for the Evaluation of Human Risk from Teratogenic Agents, Pages 17-28, F. Beck
Genetic Variability in Man as a Complicating Factor in the Extrapolation of Toxicological Data from Animals, Pages 29-39, F. Sjöqvist, C. von Bahr, L. Bertilsson
The Rational Interpretation of Species and Strain Differences in Toxicity for the Prediction of Risk to Man: Review and Concluding Remarks, Pages 41-52, H. Frohberg
Ethanol Potentiation of Liver Injury, Pages 55-64, O. Strubelt
Potentiation of Liver and Kidney Injury by Ketones and Ketogenic Substances, Pages 65-75, G.L. Plaa, W.R. Hewitt
Biochemical Mechanisms of Acetaminophen (Paracetamol) Induced Hepatic and Renal Toxicity, Pages 77-86, G.G. Duggin, J. Mohandas
The Hepatotoxicity and Nephrotoxicity of Hexachlorobutadiene, Pages 87-96, E.A. Lock, J. Ishmael
Modulation of Nephrotoxicity by Environmental Chemicals, Pages 97-104, G. Rush, J. Newton, J.B. Hook
Heme Synthesis and Degradation: Its Role in Predicting Drug Toxicity — Opening Remarks, Pages 107-110, U.A. Meyer, G.D. Sweeney
Effect of Drugs and Chemicals on δ-Aminolevulinic Acid Synthase, the Rate-limiting Enzyme of Heme Synthesis, Pages 111-119, U.A. Meyer
Effects of Drugs and Metals on Heme Degradation by the Heme Oxygenase System, Pages 121-130, G. Kikuchi, T. Yoshida, S. Ishizawa
Liver Haem as a Target for Drug Toxicity, Pages 131-138, F. De Matteis, A.H. Gibbs, P.B. Farmer, J.H. Lamb, C. Hollands
Toxic Effects of Metals on the Synthesis and Disposition of Heme, Pages 139-146, T.R. Tephly, B.L. Coffman, M.S. Abou Zeit-Har, R. Sedman, E. West, I. Simon
The Heme Biosynthetic Pathway in the Prediction of Haloaromatic Hydrocarbon Toxicity, Pages 147-159, G.D. Sweeney
An Overview on Delayed Toxic Effects of Pre- and Perinatal Drug Exposure, Pages 163-176, T. Balazs
Improvements in the Postnatal Detection of Central Nervous System Defects, Pages 177-197, H. Tuchmann-Duplessis, C. Amiel-Tison
Maldevelopment of CNS Induced by Perinatal Metabolic Insults and Possibilities of Its Regulation, Pages 199-210, O. Benešová, A. Pavlik
Altered Postnatal Development Following Intrauterine Exposure to Hormonally Active Chemicals, Pages 211-220, J.A. McLachlan, S.E. Fabro
Alcohol Intoxication and Withdrawal: Introductory Remarks, Pages 223-226, K. Kuriyama, R.G. Thurman
The Role of Mitochondrial NADH Reoxidation in the Hepatic Metabolism of Ethanol: Studies with Perfused Livers from Ethanol and CCl4-Treated Rats, Pages 227-232, T. Yuki, R.G. Thurman, K. Kuriyama
Ethanol and Membrane Cholesterol, Pages 233-237, D.B. Goldstein, J.H. Chin, C.K. Daniels, L.M. Parsons, R.C. Lyon
Susceptibility to Ethanol of Neurons in Lateral Vestibular, Spinal Trigeminal and Lateral Geniculate Nuclei, Pages 239-244, M. Sasa, Y. Ikeda, S. Fujimoto, S. Takaori, J. Ito, I. Matsuoka
Dissociation of Components of Ethanol Intoxication and Tolerance, Pages 245-251, C.J.P. Eriksson, R.A. Deitrich, M. Rusi, K. Clay, D.A. Petersen
Models of Experimental Peptic Ulcers and Therapeutic Agents, Page 255, S. Okabe, Y. Osumi
Possible Roles of Central Catecholamines in Regulation of Gastric Functions, Pages 257-261, Y. Osumi
Duodenal Ulcer and Dopamine: New Elements in Pathogenesis and Therapy, Pages 263-268, S. Szabo, G.T. Gallagher, A. Blyzniuk, E.A. Maull, A.W. Sandrock
Defensive Mechanism in Peptic Ulcer and Assessment of Anti-ulcer Agents, Pages 269-274, K. Ohe, T. Shirakawa, Y. Yokoya, H. Matsumoto, T. Fujiwara, Y. Okada, M. Onda, M. Inoue, A. Miyoshi
Differential Role of Histamine in Duodenal versus Gastric Experimental Ulcer, Pages 275-280, C.J. Pfeiffer
Can the Mechanisms of Aspirin-induced Gastric Mucosal Injury be Identified?, Pages 281-285, G.L. Kauffman, Jr
Screening of Anti-Ulcer Agents Using Experimental Ulcer Models, Pages 287-292, S. Okabe
Introduction to Models and Quality Control of Laboratory Animals, Pages 295-298, G.P. Lewis
Consideration of Provision and Characterization of Animal Models, Pages 299-307, N. Ohsawa
New Animal Models in Pharmaceutical Research, Pages 309-318, W.A. Hiddleston
Species Variation in Evaluation of Safety of Drugs in the Developing Animal, Pages 319-323, W.J. Scott
Defined Laboratory Animals, Pages 325-333, T. Nomura, Y. Tajima
Quality Control in Diets — the Attainable, Pages 335-346, J.K. Eva
Problems and Improvements in the Development of Good Laboratory Practice, Pages 347-352, P.D. Lepore
Index, Pages 353-355