Toxicological profiles - Pyridine

TOXICOLOGICAL PROFILE FOR PYRIDINE......Page 1
CONTENTS......Page 5
FOREWORD......Page 3
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.2 HOW MIGHT I BE EXPOSED TO PYRIDINE?......Page 12
1.6 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO PROTECT HUMAN HEALTH?......Page 13
1.7 WHERE CAN I GET MORE INFORMATION?......Page 14
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 16
2.2.1.3 Immunological Effects......Page 17
2.2.2.1 Death......Page 20
2.2.2.2 Systemic Effects......Page 21
2.2.2.5 Developmental Effects......Page 25
2.2.3.8 Cancer......Page 26
2.2.4.7 Genotoxic Effects......Page 27
2.3.3 Metabolism......Page 28
2.3.4.1 Inhalation Exposure......Page 29
2.4 RELEVANCE TO PUBLIC HEALTH......Page 31
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 34
2.8 MITIGATION OF EFFECTS......Page 36
2.9 ADEQUACY OF THE DATABASE......Page 37
2.9.2 Data Needs......Page 38
2.9.3 On-going Studies......Page 43
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 44
4.3 USE......Page 48
4.4 DISPOSAL......Page 50
5.2.1 Air......Page 52
5.3.1 Transport and Partitioning......Page 55
5.3.2.2 Water......Page 56
5.4.1 Air......Page 57
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 58
5.7.1 Data Needs......Page 59
5.7.2 On-going Studies......Page 61
6.2 ENVIRONMENTAL SAMPLES......Page 63
6.3.1 Data Needs......Page 64
6.3.2 On-going Studies......Page 67
7. REGULATIONS AND ADVISORIES......Page 69
8. REFERENCES......Page 71
Intermediate Exposure......Page 88
Permissible Exposure Limit (PEL)......Page 89
Uncertainty Factor (UF)......Page 90
Route of Exposure......Page 91
LOAEL......Page 92
CEL......Page 93
Key to LSE Figure......Page 94
Interpretation of Minimal Risk Levels......Page 97
ACRONYMS, ABBREVIATIONS, AND SYMBOLS......Page 99
PEER REVIEW......Page 101