Toxicological profiles - 2,3-benzofuran

TOXICOLOGICAL PROFILE FOR 2,3-BENZOFURAN......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.2 HOW MIGHT I BE EXPOSED TO 2,3-BENZOFURAN?......Page 12
1.5 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO 2,3-BENZOFURAN?......Page 13
1.7 WHERE CAN I GET MORE INFORMATION?......Page 14
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 16
2.2.2 Oral Exposure......Page 17
2.2.2.1 Death......Page 25
2.2.2.2 Systemic Effects......Page 26
2.2.2.5 Developmental Effects......Page 29
2.2.3.2 Systemic Effects......Page 30
2.3.1.2 Oral Exposure......Page 31
2.4 RELEVANCE TO PUBLIC HEALTH......Page 32
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 36
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to 2,3-Benzofuran......Page 38
2.8 MITIGATION OF EFFECTS......Page 39
2.9 ADEQUACY OF THE DATABASE......Page 40
2.9.2 Data Needs......Page 41
2.9.3 On-going Studies......Page 46
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 48
4.3 USE......Page 51
4.4 DISPOSAL......Page 52
5.2.2 Water......Page 53
5.3.1 Transport and Partitioning......Page 55
5.4.2 Water......Page 56
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 57
5.7.1 Data Needs......Page 58
5.7.2 On-going Studies......Page 60
6.1 BIOLOGICAL MATERIALS......Page 61
6.3.1 Data Needs......Page 63
6.3.2 On-going Studies......Page 66
7. REGULATIONS AND ADVISORIES......Page 67
8. REFERENCES......Page 69
Immediately Dangerous to Life or Health......Page 79
Neurotoxicity......Page 80
Target Organ Toxicity......Page 81
Uncertainty Factor......Page 82
LEGEND......Page 83
LEGEND......Page 85
Interpretation of Minimal Risk Levels......Page 89
ACRONYMS, ABBREVIATIONS, AND SYMBOLS......Page 91
PEER REVIEW......Page 94