Toxicological profiles - Hexachlorobutadiene

TOXICOLOGICAL PROFILE FOR HEXACHLOROBUTADIENE......Page 1
CONTENTS......Page 8
DISCLAIMER......Page 2
UPDATE STATEMENT......Page 3
FOREWORD......Page 4
CONTRIBUTORS......Page 6
PEER REVIEW......Page 7
LIST OF FIGURES......Page 11
LIST OF TABLES......Page 12
1. PUBLIC HEALTH STATEMENT......Page 13
1.2 WHAT HAPPENS TO HEXACHLOROBUTADIENE WHEN IT ENTERS THE ENVIRONMENT?......Page 14
1.5 HOW CAN HEXACHLOROBUTADIENE AFFECT MY HEALTH?......Page 15
1.7 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO PROTECT HUMAN HEALTH?......Page 16
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 17
2.2.1.2 Systemic Effects......Page 19
2.2.1.6 Developmental Effects......Page 23
2.2.2.1 Death......Page 24
2.2.2.2 Systemic Effects......Page 25
2.2.2.4 Neurological Effects......Page 37
2.2.2.7 Genotoxic Effects......Page 38
2.2.3.2 Systemic Effects......Page 39
2.3 TOXICOKINETICS......Page 41
2.3.1.3 Dermal Exposure......Page 42
2.3.2.4 Other Exposure Routes......Page 43
2.3.3.2 Oral Exposure......Page 44
2.3.4.2 Oral Exposure......Page 46
2.3.4.3 Dermal Exposure......Page 47
2.4 RELEVANCE TO PUBLIC HEALTH......Page 48
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 59
2.5.2 Biomarkers Used to Characterize Effects Caused by Hexachlorobutadiene......Page 60
2.7 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 61
2.8.2 Reducing Body Burden......Page 62
2.9.1 Existing Information on Health Effects of Hexachlorobutadiene......Page 63
2.9.2 Identification of Data Needs......Page 65
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 68
4.3 USE......Page 72
5.1 OVERVIEW......Page 74
5.2.1 Air......Page 75
5.3.1 Transport and Partitioning......Page 79
5.3.2.2 Water......Page 80
5.4.2 Water......Page 81
5.6 POPULATIONS WITH POTENTIALLY HIGH EXPOSURES......Page 82
5.7.1 Identification of Data Needs......Page 83
5.7.2 On-going Studies......Page 84
6.1 BIOLOGICAL MATERIALS......Page 85
6.2 ENVIRONMENTAL SAMPLES......Page 86
6.3.1 Identification of Data Needs......Page 89
7. REGULATIONS AND ADVISORIES......Page 92
8. REFERENCES......Page 98
Developmental Toxicity......Page 113
Mutagen......Page 114
Threshold Limit Value......Page 115
User’s Guide......Page 116
Acronyms, Abbreviations, and Symbols......Page 121