Toxicological profiles - 1,3-dichloropropene

TOXICOLOGICAL PROFILE FOR 1,3-DICHLOROPROPENE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.1 WHAT IS 1,3-DICHLOROPROPENE?......Page 10
1.3 HOW CAN 1,3-DICHLOROPROPENE ENTER AND LEAVE MY BODY?......Page 11
1.5 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXPOSED TO 1,3- DICHLOROPROPENE?......Page 12
2.1 INTRODUCTION......Page 13
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 16
2.2.1.2 Systemic Effects......Page 17
2.2.1.4 Neurological Effects......Page 35
2.2.1.6 Reproductive Effects......Page 36
2.2.2.1 Death......Page 37
2.2.2.2 Systemic Effects......Page 45
2.2.2.8 Cancer......Page 48
2.2.3.2 Systemic Effects......Page 49
2.2.3.8 Cancer......Page 57
2.3.1.2 Oral Exposure......Page 58
2.3.3.1 Inhalation Exposure......Page 59
2.3.4.2 Oral Exposure......Page 61
2.4 RELEVANCE TO PUBLIC HEALTH......Page 62
2.5 BIOMARKERS OF EXPOSURE AND EFFECT......Page 73
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to 1,3-Dichloropropene......Page 74
2.8 MITIGATION OF EFFECTS......Page 75
2.9.1 Existing Information on Health Effects of 1,3-dichloropropene......Page 76
2.9.2 Data Needs......Page 78
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 84
4.3 USE......Page 90
4.4 DISPOSAL......Page 91
5.1 OVERVIEW......Page 95
5.2.3 Soil......Page 96
5.3.1 Transport and Partitioning......Page 97
5.3.2.1 Air......Page 98
5.3.2.2 Water......Page 99
5.4.2 Water......Page 100
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 101
5.7 ADEQUACY OF THE DATABASE......Page 102
5.7.1 Data Needs......Page 103
5.7.2 Ongoing Studies......Page 105
6.2 ENVIRONMENTAL SAMPLES......Page 106
6.3.2 Ongoing Studies......Page 111
7. REGULATIONS AND ADVISORIES......Page 112
8. REFERENCES......Page 116
Developmental Toxicity......Page 126
Mutagen......Page 127
Threshold Limit Value (TLV)......Page 128
User s Guide......Page 129
Acronyms, Abbreviations, and Symbols......Page 134
Peer Review......Page 138