Toxicological profiles - Disulfoton

TOXICOLOGICAL PROFILE FOR DISULFOTON......Page 1
CONTENTS......Page 7
DISCLAIMER......Page 2
UPDATE STATEMENT......Page 3
PEER REVIEW......Page 4
FOREWORD......Page 5
LIST OF FIGURES......Page 10
LIST OF TABLES......Page 11
1. PUBLIC HEALTH STATEMENT......Page 12
1.3 HOW MIGHT I BE EXPOSED TO DISULFOTON?......Page 13
1.5 HOW CAN DISULFOTON AFFECT MY HEALTH?......Page 14
1.8 WHERE CAN I GET MORE INFORMATION?......Page 15
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 16
2.2.1.1 Death......Page 17
2.2.1.2 Systemic Effects......Page 18
2.2.1.4 Neurological Effects......Page 32
2.2.2.1 Death......Page 35
2.2.2.2 Systemic Effects......Page 70
2.2.2.3 Immunological and Lymphoreticular Effects......Page 75
2.2.2.4 Neurological Effects......Page 76
2.2.2.5 Reproductive Effects......Page 79
2.2.2.6 Developmental Effects......Page 80
2.2.3.1 Death......Page 81
2.2.3.2 Systemic Effects......Page 82
2.2.3.3 Immunological and Lymphoreticular Effects......Page 88
2.2.3.5 Reproductive Effects......Page 89
2.3.1.1 Inhalation Exposure......Page 90
2.3.1.2 Oral Exposure......Page 91
2.3.3 Metabolism......Page 92
2.3.4.2 Oral Exposure......Page 96
2.3.5 Mechanisms of Action......Page 97
2.4 RELEVANCE TO PUBLIC HEALTH......Page 99
2.5 BOOMERANGS OF EXPOSURE AND EFFECT......Page 120
2.5.1 Biomarkers Used to Identify or Quantify Exposure to Disulfoton......Page 121
2.6 INTERACTIONS WITH OTHER SUBSTANCES......Page 123
2.7 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 125
2.8.1 Reducing Peak Absorption Following Exposure......Page 126
2.8.3 Interfering with the Mechanism of Action for Toxic Effects......Page 127
2.9.1 Existing Information on Health Effects of Disulfoton......Page 128
2.9.2 Identification of Data Needs......Page 130
2.9.3 Ongoing Studies......Page 137
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 138
4.3 USE......Page 142
5.1 OVERVIEW......Page 143
5.2.1 Air......Page 144
5.2.2 Water......Page 145
5.3.1 Transport and Partitioning......Page 146
5.3.2.2 Water......Page 148
5.3.2.3 Sediment and Soil......Page 149
5.4.4 Other Environmental Media......Page 151
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 152
5.7.1 Identification of Data Needs......Page 154
5.7.2 Ongoing Studies......Page 156
6.1 BIOLOGICAL SAMPLES......Page 157
6.2 ENVIRONMENTAL SAMPLES......Page 160
6.3.1 Identification of Data Needs......Page 166
7. REGULATIONS AND ADVISORIES......Page 167
8. REFERENCES......Page 178
Carcinogen......Page 200
Lowest-Observed-Adverse-Effect Level......Page 201
Short-Term Exposure Limit......Page 202
User’s Guide......Page 203
Acronyms, Abbreviations, and Symbols......Page 209