Toxicological profiles - Chlorfenvinphos

TOXICOLOGICAL PROFILE FOR CHLORFENVINPHOS......Page 1
CONTENTS......Page 8
DISCLAIMER......Page 2
UPDATE STATEMENT......Page 3
FOREWORD......Page 4
CONTRIBUTORS......Page 6
PEER REVIEW......Page 7
LIST OF FIGURES......Page 11
LIST OF TABLES......Page 12
1.1 WHAT IS CHLORFENVINPHOS?......Page 13
1.3 HOW MIGHT I BE EXPOSED TO CHLORFENVINPHOS?......Page 14
1.5 HOW CAN CHLORFENVINPHOS AFFECT MY HEALTH?......Page 15
1.6 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN......Page 16
1.7 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO......Page 17
1.8 WHERE CAN I GET MORE INFORMATION?......Page 18
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 19
2.2.1.2 Systemic Effects......Page 21
2.2.1.3 Immunological and Lymphoreticular Effects......Page 25
2.2.1.4 Neurological Effects......Page 26
2.2.1.7 Genotoxic Effects......Page 27
2.2.2.1 Death......Page 28
2.2.2.2 Systemic Effects......Page 29
2.2.2.3 Immunological and Lymphoreticular Effects......Page 48
2.2.2.4 Neurological Effects......Page 50
2.2.2.5 Reproductive Effects......Page 55
2.2.2.6 Developmental Effects......Page 56
2.2.2.8 Cancer......Page 57
2.2.3.4 Neurological Effects......Page 59
2.2.3.8 Cancer......Page 60
2.3 TOXICOKINETICS......Page 61
2.3.1.3 Dermal Exposure......Page 62
2.3.2.1 Inhalation Exposure......Page 63
2.3.2.2 Oral Exposure......Page 64
2.3.2.3 Dermal Exposure......Page 65
2.3.3.2 Oral Exposure......Page 66
2.3.4.2 Oral Exposure......Page 71
2.3.5 Physiologically Based Pharmacokinetic (PBPK)/ Pharmacodynamic (PD) Models......Page 72
2.4.1 Pharmacokinetic Mechanisms......Page 75
2.4.2 Mechanisms of Toxicity......Page 78
2.4.3 Animal-to-Human Extrapolations......Page 80
Overview......Page 81
Minimal Risk Levels for Chlorfenvinphos......Page 83
Systemic Effects.......Page 88
2.6 BIOMARKERS OF EXPOSURE AND EFFECT......Page 101
2.6.1 Biomarkers Used to Identify or Quantify Exposure to Chlorfenvinphos......Page 102
2.6.2 Biomarkers Used to Characterize Effects Caused by Chlorfenvinphos......Page 104
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 105
2.8 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 106
2.9.1 Reducing Peak Absorption Following Exposure......Page 108
2.9.3 Interfering with the Mechanism of Action for Toxic Effects......Page 109
2.10.1 Existing Information on Health Effects of Chlorfenvinphos......Page 110
2.10.2 Identification of Data Needs......Page 113
2.10.3 Ongoing Studies......Page 126
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 127
4.2 IMPORT/ EXPORT......Page 130
4.3 USE......Page 131
4.4 DISPOSAL......Page 134
5.1 OVERVIEW......Page 136
5.2 RELEASES TO THE ENVIRONMENT......Page 137
5.2.2 Water......Page 139
5.3.1 Transport and Partitioning......Page 140
5.3.2.1 Air......Page 144
5.3.2.2 Water......Page 145
5.3.2.3 Sediment and Soil......Page 147
5.4.2 Water......Page 152
5.4.4 Other Environmental Media......Page 153
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 155
5.6 POPULATIONS WITH POTENTIALLY HIGH EXPOSURES......Page 156
5.7.1 Identification of Data Needs......Page 157
5.7.2 Ongoing Studies......Page 160
6.1 BIOLOGICAL SAMPLES......Page 161
6.2 ENVIRONMENTAL SAMPLES......Page 163
6.3 ADEQUACY OF THE DATABASE......Page 166
6.3.1 Identification of Data Needs......Page 168
6.3.2 Ongoing Studies......Page 170
7. REGULATIONS AND ADVISORIES......Page 171
8. REFERENCES......Page 173
Intermediate Exposure......Page 188
q1*......Page 189
Uncertainty Factor (UF)......Page 190
ATSDR MINIMAL RISK LEVEL......Page 191
MINIMAL RISK LEVEL (MRL) WORKSHEET......Page 193
USER'S GUIDE......Page 199
ACRONYMS, ABBREVIATIONS, AND SYMBOLS......Page 206