Toxicological profiles - Bis(2-chloroethyl) ether

TOXICOLOGICAL PROFILE FOR BIS(2-CHLOROETHYL) ETHER......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.4 HOW CAN BCEE AFFECT MY HEALTH?......Page 10
1.6 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 11
2.1 INTRODUCTION......Page 19
2.2.1.1 Death......Page 20
2.2.1.2 Systemic Effects......Page 25
2.2.1.5 Developmental Effects......Page 26
2.2.2.1 Death......Page 27
2.2.2.8 Cancer......Page 30
2.2.3.4 Neurological Effects......Page 31
2.3 RELEVANCE TO PUBLIC HEALTH......Page 33
2.5 LEVELS IN THE ENVIRONMENT ASSOCIATED WITH LEVELS IN HUMAN TISSUES AND/ OR HEALTH EFFECTS......Page 34
2.6.3 Metabolism......Page 36
2.6.4 Excretion......Page 37
2.9.1 Existing Information on Health Effects of BCEE......Page 39
2.9.2 Data Needs......Page 41
2.9.3 Ongoing Studies......Page 42
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 43
4.5 ADEQUACY OF THE DATABASE......Page 46
5.3.1 Transport and Partitioning......Page 47
5.3.2.2 Water......Page 48
5.4.4 Other Media......Page 49
5.7.1 Data Needs......Page 50
6.2 ENVIRONMENTAL SAMPLES......Page 51
6.3.1 Data Needs......Page 52
6.3.2 Ongoing Studies......Page 55
7. REGULATIONS AND ADVISORIES......Page 56
8. REFERENCES......Page 60
EPA Health Advisory......Page 66
No-Observed-Adverse-Effect Level......Page 67
Toxic Dose......Page 68
User s Guide......Page 69
Acronyms, Abbreviations, and Symbols......Page 75
PEER REVIEW......Page 78