Toxicological profiles - 1,2-dibromo-3-chloropropane

TOXICOLOGICAL PROFILE FOR 1,2-DIBROMO-3-CHLOROPROPANE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.1 WHAT IS 1,2-DIBROMO-3-CHLOROPROPANE?......Page 10
1.3 HOW CAN 1,2-DIBROMO-3-CHLOROPROPANE ENTER AND LEAVE MY BODY?......Page 11
1.4 HOW CAN 1,2-DIBROMO-3-CHLOROPROPANE AFFECT MY HEALTH?......Page 12
1.7 WHERE CAN I GET MORE INFORMATION?......Page 13
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 14
2.2.1.1 Death......Page 15
2.2.1.2 Systemic Effects......Page 16
2.2.1.3 Immunological Effects......Page 32
2.2.1.6 Reproductive Effects......Page 33
2.2.1.8 Cancer......Page 35
2.2.2.2 Systemic Effects......Page 36
2.2.2.4 Neurological Effects......Page 53
2.2.2.6 Reproductive Effects......Page 54
2.2.2.7 Genotoxic Effects......Page 55
2.2.3.2 Systemic Effects......Page 56
2.2.3.8 Cancer......Page 60
2.3.2.2 Oral Exposure......Page 61
2.3.3 Metabolism......Page 62
2.3.4.3 Dermal Exposure......Page 64
2.4 RELEVANCE TO PUBLIC HEALTH......Page 65
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to 1,2- Dibromo- 3- chloropropane......Page 77
2.8 MITIGATION OF TOXICOLOGICAL EFFECTS......Page 79
2.9.1 Existing Information on Health Effects of 1,2-Dibromo-3- chloropropane......Page 81
2.9.2 Data Needs......Page 83
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 87
4.3 USE......Page 91
5.1 OVERVIEW......Page 92
5.2.2 Water......Page 93
5.3.1 Transport and Partitioning......Page 95
5.3.2.3 Soil......Page 97
5.4.2 Water......Page 98
5.4.3 Soil......Page 102
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 103
5.7 ADEQUACY OF THE DATABASE......Page 104
5.7.1 Data Needs......Page 105
6.1 BIOLOGICAL MATERIALS......Page 107
6.2 ENVIRONMENTAL SAMPLES......Page 108
6.3.1 Data Needs......Page 113
7. REGULATIONS AND ADVISORIES......Page 114
8. REFERENCES......Page 118
Immediately Dangerous to Life or Health (IDLH)......Page 136
Octanol-Water Partition Coefficient (Kow)......Page 137
Uncertainty Factor (UF)......Page 138
User s Guide......Page 139
Acronyms, Abbreviations, and Symbols......Page 145
Peer Review......Page 148