Toxicogenomics-Based Cellular Models. Alternatives to Animal Testing for Safety Assessment

Content: 
Front-matter, Pages i,iii
Copyright, Page iv
List of Contributors, Pages xv-xviii, Marjam Alloul-Ramdhani, Scott S. Auerbach, Giulia Benedetti, Harrie Besselink, André Boorsma, Bram Brouwer, Ines Chaves, Maarten Coonen, Emanuela Corsini, Erik H.J. Danen, Marjo de Graauw, Eugin Destici, Marja Driessen, Jennifer Fostel, Abdoelwaheb El Ghalbzouri, Sanne A.B. Hermsen, Kristina M. Hettne, Wouter T.M. Jansen, Barae Jomaa, Jos Kleinjans,  et al.
Chapter 1.1 - Introduction to Toxicogenomics-Based Cellular Models, Pages 3-11, Jos Kleinjans
Chapter 2.1 - Application of In Vivo Genomics to the Prediction of Chemical-Induced (hepato)Carcinogenesis, Pages 15-33, Scott S. Auerbach, Richard S. Paules
Chapter 2.2 - Unraveling the DNA Damage Response Signaling Network Through RNA Interference Screening, Pages 35-54, Louise von Stechow, Bob van de Water, Erik H.J. Danen
Chapter 3.1 - Immunotoxicity Testing: Implementation of Mechanistic Understanding, Key Pathways of Toxicological Concern, and Components of These Pathways, Pages 57-65, Erwin L. Roggen, Emanuela Corsini, Henk van Loveren, Robert Luebke
Chapter 3.2 - Chemical Sensitization, Pages 67-87, Marjam Alloul-Ramdhani, Cornelis P. Tensen, Abdoelwaheb El Ghalbzouri
Chapter 3.3 - ’Omics-Based Testing for Direct Immunotoxicity, Pages 89-124, Oscar L. Volger
Chapter 4.1 - Implementation of Transcriptomics in the Zebrafish Embryotoxicity Test, Pages 127-141, Sanne A.B. Hermsen, Aldert H. Piersma
Chapter 4.2 - Transcriptomic Approaches in In Vitro Developmental Toxicity Testing, Pages 143-157, Elisa C.M. Tonk, Aldert H. Piersma
Chapter 4.3 - Thyroid Toxicogenomics: A Multi-Organ Paradigm, Pages 159-189, Barae Jomaa
Chapter 5.1 - Hepatotoxicity Screening on In Vitro Models and the Role of ’Omics, Pages 193-212, Joost van Delft, Karen Mathijs, Jan Polman, Maarten Coonen, Ewa Szalowska, Geert R. Verheyen, Freddy van Goethem, Marja Driessen, Leo van de Ven, Sreenivasa Ramaiahgari, Leo S. Price
Chapter 5.2 - An Overview of Toxicogenomics Approaches to Mechanistically Understand and Predict Kidney Toxicity, Pages 213-234, Giulia Benedetti, Bob van de Water, Marjo de Graauw
Chapter 5.3 - ’Omics in Organ Toxicity, Integrative Analysis Approaches, and Knowledge Generation, Pages 235-250, Laura Suter-Dick
Chapter 5.4 - Hepatotoxicity and the Circadian Clock: A Timely Matter, Pages 251-270, Annelieke S. de Wit, Romana Nijman, Eugin Destici, Ines Chaves, Gijsbertus T.J. van der Horst
Chapter 6.1 - Introduction to Toxicoinformatics, Pages 273-274, Rob H. Stierum
Chapter 6.2 - Toxicogenomics and Systems Toxicology Databases and Resources: Chemical Effects in Biological Systems (CEBS) and Data Integration by Applying Models on Design and Safety (DIAMONDS), Pages 275-290, Jennifer Fostel, Eugene van Someren, Tessa Pronk, Jeroen Pennings, Peter Schmeits, Jia Shao, Dinant Kroese, Rob Stierum
Chapter 6.3 - Bioinformatics Methods for Interpreting Toxicogenomics Data: The Role of Text-Mining, Pages 291-304, Kristina M. Hettne, Jos Kleinjans, Rob H. Stierum, André Boorsma, Jan A. Kors
Chapter 7.1 - Selection and Validation of Toxicogenomics Assays as Alternatives to Animal Tests, Pages 307-317, Bart van der Burg, Harrie Besselink, Bram Brouwer
Chapter 8.1 - Toxicogenomics Implementation Strategies, Pages 321-336, Wouter T.M. Jansen, Jan Hendrik R.H.M. Schretlen
Index, Pages 337-348