Toxicity and Drug Testing

00 preface_ Toxicity and Drug Testing......Page 1
00a_Part 1_ Drug Design......Page 11
01_Blood Brain Barrier Permeation......Page 13
02_Diagnostic Accuracy and Interpretation of\rUrine Drug Testing for Pain Patients:\rAn Evidence-Based Approach......Page 35
03_Experimental and Computational Methods\rPertaining to Surface Tension of\rPharmaceuticals......Page 57
04_Multi-Well Engineered Heart Tissue for Drug\rScreening and Predictive Toxicology......Page 81
05_Prediction of Partition Coefficients\rand Permeability of Drug Molecules\rin Biological Systems with Abraham Model\rSolute Descriptors Derived from Measured\rSolubilities and Water-to-Organic Solvent\rPartition Coefficients......Page 101
06_Variability of Plasma Methadone\rConcentration in Opiate Dependent\rReceiving Methadone: A Personalised\rApproach Towards Optimizing Dose......Page 139
07_Drug Synergy –\rMechanisms and Methods of Analysis......Page 153
08_Herbal Medicine in the Treatment of Malaria:\rVernonia amygdalina:\rAn Overview of Evidence and Pharmacology......Page 177
09_Experimental and Computational\rMethods Pertaining to Drug Solubility......Page 197
09a_Part 2_ Toxicity......Page 229
10_Toxic Effects of Cadmium\ron Crabs and Shrimps......Page 231
11_Paraquat, Between Apoptosis and Autophagy......Page 247
12_Prediction of Toxicity, Sensory Responses and\r3 Biological Responses with the Abraham Model......Page 271
13_Mikania glomerata and M. laevigata:\rClinical and Toxicological Advances......Page 307
14_Evaluation of Drug Toxicity for DNA\rVaccine Candidates Against Infectious\rDiseases: Hepatitis C as Experimental Model......Page 331
15_Aluminium Phosphide Poisoning......Page 355
16_Application of a New Genotoxicity Test System\rwith Human Hepatocyte Cell Lines to Improve\rthe Risk Assessment in the Drug Development......Page 371
17_Genotoxic Impurities in Pharmaceuticals......Page 397
18_Measurement Uncertainty in\rForensic Toxicology:\rIts Estimation, Reporting and Interpretation......Page 425
19_Toxicokinetics and Organ-Specific Toxicity......Page 467
20_Environmental Toxicants Induced\rMale Reproductive Disorders:\rIdentification and Mechanism of Action......Page 483