Toxic Interfaces of Neurones, Smoke and Genes: Proceeding of the European Society of Toxicology Meeting Held in Kuopio, June 16–19, 1985

Front Matter....Pages I-X
Front Matter....Pages 1-1
Nerve Membrane Ionic Channels as the Target of Toxicants....Pages 3-13
Neurochemical Effects of DDT in Rat Brain In Vivo....Pages 14-26
The Pharmacology of Simple Molecules....Pages 27-37
Membrane Lipid Changes in Organic Solvent Tolerant Neural Cells....Pages 38-45
Effects of Methylglyoxal on Central and Peripheral Cholinergic Responses....Pages 46-50
Effects of Diazepam, Tofizopam or Phenytoin During Foetal Development on Subsequent Behaviour and Benzodiazepine Receptor Characteristics in Rats....Pages 51-54
The Effect of Ethanol on the Release of Free Fatty Acids from the Brain in Vivo; A Study with Push-Pull Cannula....Pages 55-59
Front Matter....Pages 61-61
Review of Epidemiology in Relation to Passive Smoking....Pages 63-73
Aerosols of Smoke, Respiratory Physiology and Deposition....Pages 74-87
Monitoring Absorption by Means of Determination of Nicotine and Cotinine....Pages 88-102
Monitoring Urine for Inhaled Cannabinoids....Pages 103-110
Microcomputer Assisted Measurement of Inhalation Parameters During Smoking....Pages 111-114
No Difference Between Urinary Mutagenicity in Smokers of Low-Tar and Medium-Tar Cigarettes: A Double-Blind Cross-Over Study....Pages 115-119
Cigarette Smoking, Serum Lipids and Angiographically-Assessed Coronary Artery Disease....Pages 120-123
Front Matter....Pages 125-125
The Case for Isogenic Strains in Toxicological Screening....Pages 127-137
Polymorphism in Drug Metabolism — Implications for Drug Toxicity....Pages 138-146
Inter-Individual Variations in Carcinogen Metabolism....Pages 147-153
Interethnic Differences in the Detoxification of Organophosphates: The Human Serum Paraoxonase Polymorphism....Pages 154-158
DNA-Mediated Restoration of Aryl Hydrocarbon Hydroxylase Induction in a Mouse Hepatoma Mutant Defective in Nuclear Translocation of the Ah Receptor....Pages 159-162
Species Differences in the Covalent Binding of p-Chloro-o-Toluidine to DNA....Pages 163-166
Front Matter....Pages 125-125
Effects of Peroxisome Proliferators in Vivo and in Primary Hepatocyte Cultures from Chinese and Syrian Hamsters....Pages 167-167
Front Matter....Pages 169-169
Cardiotoxicity Mechanisms from the Point of View of Preclinical or Premarketing Safety Evaluation....Pages 171-177
Detection of Cardiotoxic Hazards....Pages 178-187
Interaction of Calcium Antagonists with β -Adrenoceptor Blocking Agents....Pages 188-196
Cardiotoxicity of Digitalis....Pages 197-204
Cardiotoxic Actions of Doxepin and Barium Chloride in Conscious Rabbits....Pages 205-208
Dose-Dependence of the Nifedipine/Digoxin Interaction?....Pages 209-212
Experimental Compound OR-K-242-HCl an Anilide Derivative Slows Conduction Velocity of the Heart in the Conscious Beagle Dog....Pages 213-216
Nifedipine Induces Intense Nausea and Vomiting in Young, Healthy Volunteers....Pages 217-218
The Effect of a Novel Inotropic/Vasodilating Compound on the Dog Heart at Toxicological Doses....Pages 219-219
Front Matter....Pages 221-221
Toxicology — the Next Decade....Pages 222-224
Application, Limitations and Research Requirements of in Vitro Test Systems in Toxicology....Pages 225-236
The Questionable Value of Long-Term Animal Toxicity Studies: A Regulatory Dilemma....Pages 237-239
To what Extent can Results of Experimental Studies be Extrapolated in Predicting Adverse Side Effects of Drugs in Man?....Pages 240-243
Validity of Toxicity Documents of Pesticides and Good Laboratory Practice....Pages 244-246
Carcinogenicity Testing in Nude Mouse Cell Cultures....Pages 247-250
Pharmacokinetically Governed Design of Animal Toxicity Studies of a New Antidepressant Drug....Pages 251-251
Dog and Swine as Models for Testing Indomethacin Induced Gastrointestinal Irritation....Pages 252-252
A Rapid Method for Quantitation of Toxic Heart Dilatation in Rats....Pages 253-254
On the Usefulness of Minipigs in Toxicology Testing of Pesticides....Pages 255-255
Front Matter....Pages 257-257
Cellular Defense Mechanisms Against Toxic Substances....Pages 259-271
Differences in the Induction of Autoimmune Responses in A.SW/SnJ Mice by Various Agents....Pages 272-274
Morphological Alterations Induced by Patulin on Cultured Hepatoma Cells....Pages 275-278
The Effects of Estrogen and Antiestrogens on Light-Induced Retinal Damage in Rat....Pages 279-280
Reaction Products of Styrene Oxide with Deoxynucleosides and DNA In Vitro....Pages 281-285
Binding of Styrene Oxide to Amino Acids, Human Serum Proteins and Hemoglobin....Pages 286-290
Cytogenic Effects of a Novel Antiestrogen Toremifene FC-1157a: A Comparison with Diethylstilbestrol and Tamoxifen....Pages 291-291
Toxicity of Richterite in Hemolysis Test and Macrophage Cultures....Pages 292-295
Prajmaline, an Antiarrhythmic Drug, Depresses the Hepatic Glutathione System in Rats....Pages 296-296
Effects of Diethyl Maleate on Non-protein Sulfhydryl Content and Cellular Functions of Mouse Thymocytes in Vitro....Pages 297-301
Toxic and Protective Effects of Antioxidants in Biomembranes....Pages 302-305
Reduction of Gentamicin Nephrotoxicity by the Concomitant Administration of Poly-L-Aspartic Acid and Poly-L-Asparagine in Rats....Pages 306-309
Effect of Ochratoxin A on Enzyme Activities and Macromolecules Synthesis in MDCK Cells....Pages 310-314
Mushroom Poisoning due to Cortinarius Speciosissimus : Electron Microscope Study in Rats....Pages 315-319
Effect of Organic Solvents on Human Erythrocyte Membrane Acetylcholinesterase Activity In Vitro....Pages 320-323
Vinyl Acetate, a Structural Analog of Vinyl Carbamate, Fails to Induce Enzyme Altered Foci in Rat Liver....Pages 324-325
Front Matter....Pages 327-327
Pyrethroid Metabolism: Studies on Cis- and Trans-Phenothrins, and Related Epoxide Intermediates....Pages 329-332
Effects of Antidotes on Soman-Induced Brain Changes....Pages 333-336
Experimental Studies on Dimethoate Oxidative Desulfuration....Pages 337-337
Gas Chromatographic Determination of Myo-Inositol Phosphates: Evaluation of Various Methods....Pages 338-338
Front Matter....Pages 327-327
Ethylenethiourea and Nabam Induced Alterations of Function and Morphology of Thyroid Gland in Rats....Pages 339-344
Peripheral and Central Nervous System Effects of Nabam and Ethylenethiourea in Rats....Pages 345-345
Induction of Hepatic Microsomal Mixed Function Oxidase System by Ethylenethiourea in Mice....Pages 346-350
Effects of Zineb on Hepatic Microsomal Systems in Rats and Mice....Pages 351-351
In Vitro Formation of N-Nitroso Curzate: Effect of Nitrosation Modulators....Pages 352-352
Probenecid Affects the Toxicity and Concentration of Chlorophenoxyacetic Acids in the Rat Brain....Pages 353-354
The Central Nervous System Toxicity of Chlorophenoxyacetic Acid Herbicides....Pages 355-355
Brown Adipose Tissue is a Target Tissue in 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Induced Toxicity....Pages 356-360
Stereochemical Considerations on the Inhibition of Hepatic Epoxide Hydrolase by Some Pesticides and Their Epoxides....Pages 361-361
Front Matter....Pages 363-363
Inhibition by Methylglyoxal Bis(Guanylhydrazone) of Drug Oxidation Reactions Catalyzed by Mouse Liver Microsomes In Vivo and In Vitro....Pages 365-366
Coumarin 7-Hydroxylase in Inbred Strains of Mice: Comparison with Other Microsomal Monooxygenase Activities and Induction by Pyrazole....Pages 367-370
Inhibition of Microsomal Monooxygenases in Vitro by Aromatic Hydrocarbons....Pages 371-373
Induction of Cytochrome P-450 Mediated Mono-Oxygenase Reactions and Conjugation Activities in Freshwater Crayfish ( Astacus astacus )....Pages 374-377
Monooxygenase Activity of Fish Liver in Biomonitoring Aquatic Environment....Pages 378-381
Influence of Age, Hexobarbital, and Aniline on NADPH/NADH Dependent Hydrogen Peroxide Production in Rat Hepatic Microsomes....Pages 382-385
Structure Activity Studies on the Induction of Peroxisomal Enzyme Activities by a Series of Phthalate Monoesters in Primary Rat Hepatocyte Cultures....Pages 386-389
Front Matter....Pages 391-391
Studies on the Inhibition of Brain Synaptosomal Na + /K + -ATPase by Mercury Chloride and Methyl Mercury Chloride....Pages 393-396
Lead Does not Affect Calmodulin-Induced Activation of Calcium-Dependent Adenosine Triphosphatase in Human Red Blood Cell Membranes....Pages 397-400
Effect of Some Heavy Metal Salts on Lipid Peroxidation After Acute Intoxication and Subchronic Exposure....Pages 401-401
Triphenyl Tin Hepatotoxicity in Rats....Pages 402-405
Front Matter....Pages 391-391
Toxicity of Iceland Lichen and Reindeer Lichen....Pages 406-409
Metal Pollution in a Salt Marsh and its Effect on Sheep....Pages 410-413
Changes of Vascular Reactivity Induced by Lead....Pages 414-415
Cardiotoxic and Bronchoconstrictor Effects of Industrial Metal Fumes Containing Barium....Pages 416-420
Immunological Unresponsiveness to Chromium or Nickel in the Guinea-Pig Induced by Stainless Steel Welding Fume Components....Pages 421-422
Front Matter....Pages 423-423
Structure-Activity Relationshipof Nitroimidazo (2,1-b) Thiazoles in the Salmonella Mutagenicity Assay....Pages 425-429
Erythrocyte-Dependent Metabolic Activation of 2-Aminofluorene in Salmonella Mutagenicity Assay....Pages 430-430
Sulfur Dioxide Induced Bronchitis in Rats....Pages 431-435
Perfused and Ventilated Guinea-Pig Lung: A Method for Evaluating Xenobiotic Effects on Arachidonic Acid Using Formaldehyde....Pages 436-440
Retardation of Spermiation Following Short-Term Treatment of Rats with Theobromine....Pages 441-446
Assay of Possible Formation of Antigenic Components in Heat-Treated Plasma Protein Preparations....Pages 447-450
Histopathological and Morphometrical Analysis Applied to Skin Changes in NMRI Mice Induced by Dithranol (Anthranil) and its Acyl Analogs....Pages 451-454
Variable Effects of Irritants (Methylmethacrylate, Terphenyls, Dithranol and Methylglyoxal-bis-Guanylhydrazone) on the Fine Structure of the Epidermis....Pages 455-455
Electron Microscopy and Immunohistochemistry of Toxic and Allergic Effects of Methylmethacrylate on the Skin....Pages 456-459
Occupational Exposure to Chlorinated Organic Solvents and its Effect on the Renal Excretion of N-Acetyl-Beta-D-Glucosaminidase....Pages 460-464
Toxicity and Kinetics of Perfluoro-octanoic Acid in the Wistar Rat....Pages 465-468
Toxicity Studies on a New Aspirin Pro-Drug....Pages 469-469
Adrenocortical Activation is Independent from Systemic Toxicity in Long-Term Hydroxyurea Treatment....Pages 470-470
Neuroendocrine (Carcinoid) Tumours of the Glandular Stomach of the Rat Following Treatment with an H 2 -Receptor Antagonist....Pages 471-471
Dihydroergotamine (DHE) — a Toxicological and Pharmacokinetic Study in Cynomolgus Monkeys Following Administration by the Intra-Nasal Route....Pages 472-472
Front Matter....Pages 423-423
Effects of Exercise and Physical Fitness on Theophylline Half-life in Rats....Pages 473-473
Determination of Doxorubicin and Doxorubicin-3-ol in Rat Heart....Pages 474-478
Back Matter....Pages 479-487