Toxic Interactions

Content: 
Front Matter, Page iii
Copyright, Page iv
Contributors, Pages xi-xii
Preface, Pages xiii-xiv, Robin S. Goldstein, William R. Hewitt, Jerry B. Hook
1 - Factors to Consider in the Design and Evaluation of Chemical Interaction Studies in Laboratory Animals, Pages 3-30, Gabriel L. Plaa, Manon Vézina
2 - The Role of the Mixed-Function Oxidase System in the Toxication and Detoxication of Chemicals: Relationship to Chemical Interactions, Pages 31-60, Gregory L. Kedderis
3 - Oxidation of Xenobiotics by Prostaglandin H Synthase, Pages 61-86, Terry V. Zenser, Bernard B. Davis
4 - The Role of Glutathione in Protection against Chemically Induced Cell Injury, Pages 87-114, Peter F. Smith, Glenn F. Rush
5 - Displacement Interactions Resulting from Competition for Binding Sites on Proteins, Pages 115-147, Walter D. Wosilait, Richard H. Luecke
6 - The Impact of Renal Dysfunction on Drug Handling and How to Compensate for It, Pages 149-173, D. Craig Brater
7 - Use of Microfluorometric and Micropolarographic Techniques to Study Zone-Specific Hepatotoxicity, Pages 177-205, Steven A. Belinsky, Frederick C. Kauffman, Ronald G. Thurman
8 - Chemical Alterations of Volatile Anesthetic Agent-Induced Hepato- and Nephrotoxicity, Pages 207-231, Laurence S. Kaminsky
9 - Prevention of Chemically Induced Liver Injury, Pages 233-257, José Alberto Castro
10 - Biochemical Mechanisms of Xenobiotic-Induced Nephrotoxicity, Pages 261-298, Robin S. Goldstein, Chao-Hen Kuo, Jerry B. Hook
11 - Toxic Actions of the Aminoglycoside Antibiotics on the Kidney, Pages 299-320, H. David Humes
12 - Ketonic Potentiation of Haloalkane-Induced Nephrotoxicity, Pages 321-366, Merl F. Raisbeck, Esther M. Brown, Sumolya Kanchanapangka, William R. Hewitt
13 - Chronic Chemical Injury to the Kidney, Pages 367-406, William M. Kluwe
14 - Toxicological Interactions in the Pathogenesis of Lung Injury, Pages 409-442, R.C. Lindenschmidt, H.P. Witschi
15 - Drug-Induced Cardiotoxicity, Pages 443-467, William D. Matthews, Kam Jim
Index, Pages 469-488