Topics and Perspectives in Adenosine Research: Proceedings of the 3rd International Symposium on Adenosine, Munich, June 1986

Front Matter....Pages I-XIV
Front Matter....Pages 1-1
Agonist and Antagonist Radioligands and Photoaffinity Labels for the Adenosine A 1 Receptor....Pages 3-14
Functional Characterization of A 1 Adenosine Receptors by Photoaffinity Labelling....Pages 15-22
Analogues of Adenosine, Theophylline, and Caffeine: Selective Interactions with A 1 and A 2 Adenosine Receptors....Pages 23-36
Structural Studies on Adenosine R i Receptors from Rat Cerebral Cortex....Pages 37-48
Biochemical and Autoradiographic Approaches to the Characterization of Adenosine Receptors in Brain....Pages 49-58
Adenosine Receptor Subtypes: Binding Studies....Pages 59-73
Central Sites of Adenosine Action and Their Interaction with Various Drugs....Pages 74-88
Nucleoside Transport Inhibition In Vitro and In Vivo....Pages 89-101
Kinetic and Molecular Properties of Nucleoside Transporters in Animal Cells....Pages 102-117
Drug Interactions with Nucleoside Transport Systems....Pages 118-130
Front Matter....Pages 131-131
Regulation and Function of 5′-Nucleotidases....Pages 133-144
Kinetics of Endothelial Cell Ectonucleotidases....Pages 145-154
Critical Evaluation of the Role of Ecto- and Cytosolic 5′-Nucleotidase in Adenosine Formation....Pages 155-169
New Insights into the Mechanism of Myocardial Adenosine Formation....Pages 170-187
Cardiac Myocyte and Coronary Endothelial Cell Adenosine Transport....Pages 188-198
The Importance of the Transmethylation Pathway for Adenosine Metabolism in the Heart....Pages 199-208
Uric Acid, the Major Catabolite of Cardiac Adenine Nucleotides and Adenosine, Originates in the Coronary Endothelium....Pages 209-222
Thermodynamic State of Cytosolic Adenylates in Guinea Pig Myocardium. Energy-Linked Adaptive Changes in Free Adenylates and Purine Nucleoside Release....Pages 223-235
Front Matter....Pages 237-237
On Multiple Targets for Fat Cell Receptors....Pages 239-248
The Renal and Epithelial Actions of Adenosine....Pages 249-260
Front Matter....Pages 237-237
Adenosine and Thermogenesis in Brown Adipose Tissue: Interaction with Beta and Alpha Adrenergic Responses....Pages 261-274
The Hormone-Modulatory Effects of Adenosine in Skeletal Muscle....Pages 275-285
Effects of Adenosine on Human Neutrophil Function and Cyclic AMP Content....Pages 286-298
A New Function for Adenosine: Protection of Vascular Endothelial Cells from Neutrophil-Mediated Injury....Pages 299-308
Formation of Adenosine by Vascular Endothelium: a Homeostatic and Antithrombogenic Mechanism?....Pages 309-320
Front Matter....Pages 321-321
Ionic Channels and Adenosine in Isolated Heart Cells....Pages 323-335
The Negative Chronotropic Effect of Adenosine in Sinus Node Cells....Pages 336-343
Regulation of Atrioventricular Node Function by Adenosine....Pages 344-355
The Antiadrenergic Actions of Adenosine in the Heart....Pages 356-368
Mechanism of the “Antiadrenergic” Effects of Adenosine on Myocardial Force of Contraction....Pages 369-382
Further Evidence Against Adenosine-Catecholamine Antagonism In Vivo: Investigations with Treadmill Exercise in Dogs....Pages 383-394
Adenosine in the Local Regulation of Blood Flow: Some Controversies....Pages 395-405
Adenosine in the Local Regulation of Blood Flow: Current Controversies....Pages 406-415
5′-Nucleotidase Inhibitors and the Myocardial Reactive Hyperemia and Adenosine Content....Pages 416-424
Estimates of Interstitial Adenosine in Isolated Rat Hearts from Surface Exudates During Rapid Pacing and EHNA Infusion....Pages 425-438
Intra-Arterial Adenosine Deaminase: a Tool for Assessing Physiologic Functions of Adenosine....Pages 438-444
A Critique on the Use of Adenosine Deaminase to Test the Adenosine Hypothesis: Disregarded Implicit Assumptions....Pages 445-453
Adenosine Receptors at the Coronary Endothelium: Functional Implications....Pages 454-469
Endothelial Activation by Adenosine and Coronary Flow Regulation in the Guinea Pig Heart....Pages 470-479
Cellular Compartmentation of Adenosine in the Heart....Pages 480-485
Front Matter....Pages 321-321
Mechanisms of Adenosine- and ATP-Induced Relaxation in Rabbit Femoral Artery: Role of the Endothelium and Cyclic Nucleotides....Pages 486-496
Front Matter....Pages 497-497
Mechanisms Underlying Physiological Responses to Adenosine in the Central Nervous System....Pages 499-508
Interactions Between the Neuromodulator Adenosine and the Classic Transmitters....Pages 509-520
Pre- Versus Postsynaptic Effects of Adenosine on Neuronal Calcium Fluxes....Pages 521-532
Adenosine-Mediated Presynaptic Inhibiton of Sympathetic Innervation as an Explanation of Functional Hyperemia....Pages 533-536
Intracellular Calcium Mediating the Actions of Adenosine at Neuromuscular Junctions....Pages 537-548
Inhibition of Calcium Currents by an Adenosine Analogue 2-Chloroadenosine....Pages 549-558
Adenosine, Cyclic AMP and Nerve Conduction....Pages 559-573
The Role of Adenosine Neuromodulation in Postanoxic Hyperexcitability....Pages 574-585
Role of Adenosine in the Regulation of Breathing....Pages 586-596
Front Matter....Pages 597-597
Levels and Cardiovascular Effects of Adenosine in Humans....Pages 599-613
The Bronchoconstrictor Activity of Adenosine in Asthma....Pages 614-624
Adenosine Deaminase Deficiency: Recent Observations Pertinent to Investigation of the Physiologic Role of Adenosine in Man....Pages 625-629
Back Matter....Pages 630-634