Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment

Front Matter ....Pages i-xiii
 The Prevalence of Smoking and Its Associated Diseases  (Ming D. Li)....Pages 1-11
 Addiction Genetics: Basic Concepts and Techniques  (Ming D. Li)....Pages 13-21
 Estimation of Genetic and Environmental Contributions to Smoking Addiction  (Ming D. Li)....Pages 23-34
 Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses  (Ming D. Li)....Pages 35-46
 Involvement of Variants in Gene Clusters CHRNA5/A3/B4 on Chromosome 15 to Smoking Behaviors and Lung Cancer  (Ming D. Li)....Pages 47-69
 Contribution of Variants in CHRNB3/A6 Gene Cluster on Chromosome 8 to Smoking Dependence  (Ming D. Li)....Pages 71-93
 Genetic Contribution of Variants in GABAergic Signaling to Nicotine Dependence  (Ming D. Li)....Pages 95-105
 Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions  (Ming D. Li)....Pages 107-142
 Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Smoking Dependence  (Ming D. Li)....Pages 143-152
 Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction  (Ming D. Li)....Pages 153-181
 Contribution of Gene–Gene and Gene–Environment Interactions to Tobacco Smoking  (Ming D. Li)....Pages 183-197
 Identification of Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation  (Ming D. Li)....Pages 199-213
 Neuroproteomics and Its Applications in Research on Nicotine and Other Drugs of Abuse  (Ming D. Li)....Pages 215-242
 Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases  (Ming D. Li)....Pages 243-262
 Tobacco Smoking, Food Intake, and Weight Control  (Ming D. Li)....Pages 263-286
 Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor  (Ming D. Li)....Pages 287-302
 DNA Methylation Analysis Reveals a Strong Connection Between Tobacco Smoking and Cancer Pathogenesis  (Ming D. Li)....Pages 303-317
 Evolutionary Relations of Genes Encoding Nicotinic Acetylcholine Receptor Subunits  (Ming D. Li)....Pages 319-338
 Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation  (Ming D. Li)....Pages 339-349
 Background, Biology and Health Concerns of Electronic Cigarettes  (Ming D. Li)....Pages 351-359
 Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research  (Ming D. Li)....Pages 361-365