Tissue engineering and artificial organs

Front Cover......Page 1
Introduction and Preface......Page 8
Editor-in-Chief......Page 14
Contributors......Page 16
Contents......Page 22
1.  Historical Perspective and Basics of Molecular Biology......Page 30
2.  Systems and Technology Involving Bacteria......Page 52
3.  Recombinant DNA Technology Using Mammalian Cells......Page 62
4.  Biomimetic Systems......Page 78
5.  Diffusional Processes and Engineering Design......Page 92
6.  Microvascular Heat Transfer......Page 102
7.  Perfusion Effects and Hydrodynamics......Page 118
8.  Animal Surrogate Systems......Page 134
9.  Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease......Page 144
10.  Control of the Microenvironment......Page 160
11.  Interstitial Transport in the Brain: Principles for Local Drug Delivery......Page 178
12.  Tools for Genome Analysis......Page 194
13.  Vaccine Production......Page 208
14.  Protein Engineering......Page 224
15.  Metabolic Engineering......Page 234
16.  Monoclonal Antibodies and Their Engineered Fragments......Page 246
17.  Biomolecular Engineering in Oligonucleotide Applications......Page 268
18.  Gene Therapy......Page 290
19.  Bio-Nanorobotics: State of the Art and Future Challenges......Page 310
20.  DNA as a Scaffold for Nano-Structure Assembly......Page 356
21.  Directed Evolution of Proteins for Device Applications......Page 370
22.  Semiconductor Quantum Dots for Molecular and Cellular Imaging......Page 376
23.  Bionanotechnology for Bioanalysis......Page 386
24.  Nano-Hydroxyapatite for Biomedical Applications......Page 392
25.  Nanotechnology Provides New Tools for Biomedical Optics......Page 404
26.  Nanomaterials Perspectives and Possibilities in Nanomedicine......Page 414
27.  Biomedical Nanoengineering for Nanomedicine......Page 434
28.  Physiogenomics: Integrating Systems Engineering and Nanotechnology for Personalized Medicine......Page 444
29.  Bionanotechnology Patenting: Challenges and Opportunities......Page 454
30.  Fundamentals of Stem Cell Tissue Engineering......Page 474
31.  Growth Factors and Morphogens: Signals for Tissue Engineering......Page 484
32.  Extracellular Matrix: Structure, Function, and Applications to Tissue Engineering......Page 490
33.  Mechanical Forces on Cells......Page 512
34.  Cell Adhesion......Page 530
35.  Cell Migration......Page 548
36.  Inflammatory and Immune Responses to Tissue Engineered Devices......Page 570
37.  Polymeric Scaffolds for Tissue Engineering Applications......Page 582
38.  Calcium Phosphate Ceramics for Bone Tissue Engineering......Page 600
39.  Biomimetic Materials......Page 618
40.  Nanocomposite Scaffolds for Tissue Engineering......Page 626
41.  Roles of Thermodynamic State and Molecular Mobility in Biopreservation......Page 638
42.  Drug Delivery......Page 658
43.  Gene Therapy......Page 682
44.  Tissue Engineering Bioreactors......Page 698
45.  Animal Models for Evaluation of Tissue-Engineered Orthopedic Implants......Page 716
46.  The Regulation of Engineered Tissues: Emerging Approaches......Page 726
47.  Bioengineering of Human Skin Substitutes......Page 742
48.  Nerve Regeneration: Tissue Engineering Strategies......Page 760
49.  Gene Therapy and Tissue Engineering Based on Muscle-Derived Stem Cells: Potential for Musculoskeletal Tissue Regeneration and Repair......Page 782
50.  Tissue Engineering Applications — Bone......Page 796
51.  Cartilage Tissue Engineering......Page 818
52.  Tissue Engineering of the Temporomandibular Joint......Page 830
53.  Engineering Smooth Muscle......Page 852
54.  Esophagus: A Tissue Engineering Challenge......Page 866
55.  Tissue Engineered Vascular Grafts......Page 890
56.  Cardiac Tissue Engineering: Matching Native Architecture and Function to Develop Safe and Efficient Therapy......Page 904
57.  Tissue Engineering of Heart Valves......Page 928
58.  Tissue Engineering, Stem Cells and Cloning for the Regeneration of Urologic Organs......Page 948
59.  Hepatic Tissue Engineering for Adjunct and Temporary Liver Support......Page 972
60.  Tissue Engineering of Renal Replacement Therapy......Page 992
61.  The Bioengineering of Dental Tissues......Page 1006
62.  Tracheal Tissue Engineering......Page 1020
63.  Artificial Heart and Circulatory Assist Devices......Page 1052
64.  Cardiac Valve Prostheses......Page 1060
65.  Vascular Grafts......Page 1084
66.  Artificial Lungs and Blood–Gas Exchange Devices......Page 1092
67.  Artificial Kidney......Page 1112
68.  Peritoneal Dialysis Equipment......Page 1136
69.  Therapeutic Apheresis and Blood Fractionation......Page 1150
70.  Liver Support Systems......Page 1166
71.  Artificial Pancreas......Page 1182
72.  Nerve Guidance Channels......Page 1200
73.  Tracheal, Laryngeal, and Esophageal Replacement Devices......Page 1212
74.  Artificial Blood......Page 1226
75.  Artificial Skin and Dermal Equivalents......Page 1242
76.  Beneficence, Nonmaleficence, and Medical Technology......Page 1260
77.  Ethical Issues Related to Clinical Research......Page 1268
Index......Page 1274