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دانلود کتاب Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer
دانلود کتاب اهداف دارویی و گیاه پزشکی برای سرطان سینه سه گانه منفی
مشخصات کتاب
Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer
ویرایش:
نویسندگان: Acharya Balkrishna
سری:
ISBN (شابک) : 9815079794, 9789815079791
ناشر: Bentham Science Publishers
سال نشر: 2023
تعداد صفحات: 228
[230]
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 28 Mb
قیمت کتاب (تومان) : 42,000
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توجه داشته باشید کتاب اهداف دارویی و گیاه پزشکی برای سرطان سینه سه گانه منفی نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب اهداف دارویی و گیاه پزشکی برای سرطان سینه سه گانه منفی
سرطان پستان منفی سه گانه (TNBC) یک شکل بیولوژیکی تهاجمی سرطان سینه است و تقریباً 10 تا 15 درصد از کل بیماران سرطان سینه را تشکیل می دهد. متاستاز از راه دور، فقدان درمان های هدفمند بالینی و نشانگرهای پیش آگهی، درمان بیماری را دشوار می کند. تاکنون کار زیادی روی این بیماری کشنده انجام نشده است. این کتاب مروری بر علت TNBC، استراتژی‌های درمانی و نشانگرهای پیش‌آگهی آن برای شناسایی نتیجه درمان‌های استاندارد ارائه می‌کند. مسیرهای سیگنالی مانند تکثیر سلولی، رگ‌زایی، تهاجم و متاستاز، آپوپتوز، اتوفاژی و سایر مواردی که در پیچیده‌تر کردن این بیماری دخیل هستند، در فصل‌های توضیح داده شده است. درک در مورد مکانیسم های بیماری تمام داروهای ممکن در مراحل پیش بالینی یا بالینی نیز با داده هایی ذکر شده اند که کارایی آنها را در هدف قرار دادن ژن های تغییر یافته نشان می دهد. این کتاب همچنین خوانندگان را با داروهای گیاهی که قدرت بالایی برای هدف قرار دادن TNBC نشان می‌دهند، آنالوگ‌های مصنوعی آنها که در طول شیمی‌درمانی استفاده می‌شوند و توانایی آنها در مبارزه با مقاومت شیمیایی معرفی می‌کند. مفهوم فن‌آوری گیاهی نیز مورد بحث قرار گرفته است. این کتاب به ایجاد آگاهی در میان طیف وسیعی از خوانندگان در مورد TNBC کمک می کند. این به اولویت دادن به ارتقای امکانات مراقبت های بهداشتی و طراحی مجدد استراتژی های درمانی آینده برای ارائه حداکثر سود به بیماران سرطان پستان اشاره می کند.
توضیحاتی درمورد کتاب به خارجی
Triple negative breast cancers (TNBC) are a biologically aggressiveform of breast cancer and constitute approximately 10-15% of all breast cancerpatients. Distant metastasis, lack of clinically targeted therapies andprognostic markers, makes the disease difficult to treat. Till now not muchwork has been carried out on this deadly disease. This book provides an overview of TNBC etiology, its treatmentstrategies and prognostic markers to identify the outcome of standard therapies.Signalling pathways namely cell proliferation, angiogenesis, invasion andmetastasis, apoptosis, autophagy and others involved in complicating thedisease have been described in the chapters to convey an understanding aboutthe disease mechanisms. All the possible drugs either in pre-clinical orclinical stages have also been mentioned with data that depicts their efficiencyin targeting altered genes. The book also introduces the reader to herbalmedicine exhibiting high potency to target TNBC, their synthetic analogs usedduring chemotherapy and their ability to fight against chemoresistance. Theconcept of phytonanotechnology has also been discussed. The book helps createawareness among a broad range of readers about TNBC. It points to prioritizingthe upgradation of health care facilities and re-designing future treatmentstrategies to provide maximum benefit to breast cancer patients.
فهرست مطالب
Cover Title Copyright End User License Agreement Contents Foreword Preface List of Contributors Etiological Insights into TNBC and their Related Catastrophic Risks Haritha H Nair1 and Ruby John Anto1,* INTRODUCTION Epigenetic Profiling of Triple Negative Breast Cancer DNA Methylation Altering Triple Negative Breast Cancer Expression Histone Modification Altering Triple Negative Breast Cancer miRNA Altering Triple Negative Breast Cancer Long Non-coding RNA Signature Altering Triple Negative Breast Cancer Expression An Insight of Molecular Characterization of Triple Negative Breast Cancer MOLECULAR CLASSIFICATION OF TRIPLE NEGATIVE BREAST CANCER Basal Like (BL1 & BL2) Subtype of Triple Negative Breast Cancer Immunomodulatory Subtype of Triple Negative Breast Cancer Mesenchymal and Mesenchymal Stem Like Subtype of Triple Negative Breast Cancer Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer Claudin Low Subtype of Triple Negative Breast Cancer HETEROGENEOUS NATURE OF TRIPLE NEGATIVE BREAST CANCER: A STUMBLING BLOCK POSSIBILITY OF SURVIVAL IN TRIPLE NEGATIVE BREAST CANCER UPDATES OF TRIPLE NEGATIVE BREAST CANCER ACROSS THE GLOBE Prevalence of Triple Negative Breast Cancer Amongst Barbadian Women Prevalence of Triple Negative Breast Cancer Amongst African Women Prevalence of Triple Negative Breast Cancer Amongst Oman Women Prevalence of Triple Negative Breast Cancer Amongst New Zealand Women CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES A Clinical Cognizance of Molecular and Pathological Diagnostic Approach of TNBC Acharya Balkrishna1,2, Usman Umar Zango3, Saima Kauser Nasir4 and Vedpriya Arya1,* INTRODUCTION CLINICO-PATHOLOGICAL CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER Immunohistochemistry of Triple Negative Breast Cancer GENOMIC CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER Analysis of Emerging Mutations in Triple Negative Breast Cancer Biology of Circulating Tumor DNA and its Implication in Characterization of Triple Negative Breast Cancer PROTEOMIC CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER TRANSCRIPTOMIC ANALYSIS OF TRIPLE NEGATIVE BREAST CANCER RADIOLOGICAL CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER MRI Analysis of Triple Negative Breast Cancer Mammography of Triple Negative Breast Cancer CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Molecular Sub-Typing and Exploration of Key Signalling Pathways Involved in Complicating the Disease Nikhil Ponnoor Anto1, Amitha Muraleedharan2 and Rashmi Mittal3,* INTRODUCTION Aetiology of Triple Negative Breast Cancer Subtypes Sub-Classification of Triple Negative Breast Cancer on Basis of Aberrated Copy Number Sub-Classification of Triple Negative Breast Cancer on Basis of Histology Sub-Classification of Triple Negative Breast Cancer on Basis of Proteome Analysis Sub-Classification of Triple Negative Breast Cancer on Basis of Mutations MOLECULAR SIGNALING PATHWAYS INVOLVED IN TRIPLE NEGATIVE BREAST CANCER Role of Angiogenesis in Complicating Triple Negative Breast Cancer Role of Altered Apoptosis in Complicating Triple Negative Breast Cancer Role of Altered Autophagy in Complicating Triple Negative Breast Cancer Role of Metastasis in Complicating Triple Negative Breast Cancer Cells Role of Molecular Signaling Pathways Involved in Complicating Triple Negative Breast Cancer IDENTIFICATION OF OTHER GENES AND SIGNALING PATHWAYS INVOLVED IN COMPLICATING TNBC Role of Androgen Receptors in Complicating TNBC Role of miRNAs in Triple Negative Breast Cancer Role of Estrogen Receptor Related Receptor in Complicating Triple Negative Breast Cancer Role of other Signaling Pathways in Complicating Triple Negative Breast Cancer CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Pre-Clinical and Clinical Evidence of Recent Therapeutic Trends and Spotting Possibility of Cure in Near Future Amitha Muraleedharan1, Sagar Kumar2 and Rashmi Mittal2,* INTRODUCTION Current Paradigm of Therapeutic Approach Against Triple Negative Breast Cancer Surgery in Triple Negative Breast Cancer Cases Radiotherapy in Triple Negative Breast Cancer Chemotherapy in Triple Negative Breast Cancer PRE-CLINICAL AND CLINICAL EVIDENCE OF THERAPEUTIC REGIMENS AGAINST TRIPLE NEGATIVE BREAST CANCER Anti-angiogenic Agents in Treatment of Triple Negative Breast Cancer Anti-Androgen Receptors against Triple Negative Breast Cancer Apoptosis Inducing Drugs against Triple Negative Breast Cancer Immunomodulatory Agents against Triple Negative Breast Cancer Cell Cycle Inhibitors for Triple Negative Breast Cancer Inhibitors of Pro-Survival Signalling Pathways in Triple Negative Breast Cancer COMBINATIONAL THERAPEUTIC APPROACH AGAINST TRIPLE NEGATIVE BREAST CANCER CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Evaluating Fate of Emerging Resistance Hitting the Brakes on Conventional Treatment Approach Nikhil Ponnoor Anto1 and Rashmi Mittal2,* INTRODUCTION AN INSIGHT OF FACTORS RESPONSIBLE BEHIND CHEMORESISTANCE IN TRIPLE NEGATIVE BREAST CANCER Role of Cancer Stem Cell in Inducing Resistance Role of Hypoxia in Inducing Resistance Role of Enhanced Lysosomal Biomass in Inducing Resistance Role of Metabolic Interaction with Tumor-Associated Macrophages in Inducing Resistance Role of PTEN and PI3k/Akt/mTOR Pathway in Inducing Resistance Role of ABC Transporters in Inducing Resistance MOLECULAR SIGNATURES OF CHEMOSENSITIVITY IN TRIPLE NEGATIVE BREAST CANCER Altered miRNA Expression as Predictor of Chemoresistance Analysis of Transcriptional Signatures as Predictor of Chemoresistance Role of Tumor Infiltrating Lymphocytes as Predictor of Chemoresistance DRUG REPURPOSING IN TRIPLE NEGATIVE BREAST CANCER COMBINATIONAL TARGETED AND BIOLOGICAL THERAPIES TO OVERCOME TRIPLE NEGATIVE BREAST CANCER CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Herbal Medicine: Prejudice to Realm of Reality Against TNBC Balachandran S. Vinod1 and Ruby John Anto2,* INTRODUCTION NATURAL PRODUCTS AGAINST TRIPLE NEGATIVE BREAST CANCER Role of Polysaccharides in Targeting Triple Negative Breast Cancer Role of Phenols in Targeting Triple Negative Breast Cancer Role of Saponins in Targeting Triple Negative Breast Cancer Role of Flavonoids in Targeting Triple Negative Breast Cancer Role of Taxanes in Targeting Triple Negative Breast Cancer ROLE OF HERBAL MEDICINES IN TARGETING MOLECULAR SIGNALLING PATHWAYS INVOLVED IN TRIPLE NEGATIVE BREAST CANCER Role of Herbal Medicine in Targeting Angiogenesis Role of Herbal Medicine in Arresting Cell Cycle Role of Herbal Medicine in Inducing Metastasis Role of Herbal Medicine in Inducing Apoptosis Role of Herbal Medicine in Inducing Autophagy POTENTIAL ROLE OF HERBAL MEDICINE IN TARGETING SIGNALLING PATHWAYS IN TRIPLE NEGATIVE BREAST CANCER Herbal Medicine Targeting Akt/mTOR/NF-kB Signalling Pathways Herbal Medicine Targeting STAT3 Signalling Herbal Medicine Targeting Wnt/β-Catenin Sigalling Pathway COMBINATIONAL THERAPEUTIC APPROACH AGAINST TRIPLE NEGATIVE BREAST CANCER USING HERBAL MEDICINE CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics Sreekumar Usha Devi Aiswarya1 and Smitha V. Bava1,* INTRODUCTION Phyto-Constituents as Genetic or Epigenetic Modulator of TNBC Phytochemicals Induced Demethylation in Triple Negative Breast Cancer Phytochemical Induced Histone De-acetylation in TNBC PHYTOCHEMICAL MEDIATED INHIBITION OF MOLECULAR TARGETS IN TRIPLE-NEGATIVE BREAST CANCER Phytochemical Mediated Inhibition of Cell Proliferation in TNBC Phytochemical Mediated Inhibition of Metastasis in TNBC Phytochemical Mediated Induction of Apoptosis in TNBC Phytochemicals Induced Autophagy in TNBC Phytochemical Mediated Inhibition of Angiogenesis in TNBC COMBINATIONAL DRUG THERAPY TO RE-SENSITIZE CONVENTIONAL DRUG TARGETS USING HERBAL MEDICINE AGAINST TNBC Combinational Therapy Comprising Herbal Medicine Along with Doxorubicin Against TNBC Combinational Therapy Comprising Herbal Medicine Along with Docetaxel Against TNBC Combinational Therapy Comprising Herbal Medicine Along with Paclitaxel Against TNBC Combinational Therapy Comprising Herbal Medicine Along with Bicalutamide POSSIBLE CHALLENGES LIMITING APPLICATION OF PHYTOCHEMICALS AGAINST TNBC Limiting Solubility and Poor Absorption of Phytochemicals in TNBC CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Phyto-nanotechnology: Enhancing Plant Based Chemical Constituent Mediated Anticancer Therapies Usman Umar Zango1, Aminu Abubakar2, Rohit Saxena3 and Vedpriya Arya4,* INTRODUCTION NANOTECHNOLOGY-BASED THERAPEUTIC APPROACH FOR TRIPLE NEGATIVE BREAST CANCER Smart Nanoparticles for Treatment of TNBC Cell Membrane Coated Nano-particles For Treatment of TNBC Immunological Cells-Based Nanosystems for Treatment of TNBC NANO-SOLDIERS FOR TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Role of Nano-soldiers in Enhancing Bioavailability of Phytochemicals Against TNBC Role of Nano-Soldiers in Enhancing Targeted Delivery of Phytochemicals Against TNBC NANO-PHYTOCHEMICALS AGAINST TRIPLE NEGATIVE BREAST CANCER Anacardic Acid- Nanoconjugates Against Triple Negative Breast Cancer Betulinic Acid-Nanoconjugates Against Triple Negative Breast Cancer EGCG Nanoconjugates Against Triple Negative Breast Cancer Gambogic Acid Nanoconjugates Against Triple Negative Breast Cancer Resveratrol Nanoconjugates against Triple Negative Breast Cancer Curcumin Nano Conjugates Against Triple Negative Breast Cancer CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCE Novel Implications of Prognostic Markers to Monitor the Disease: An Overview Rohit Saxena1, Ankit Gupta2, Vikrant Singh3, Vipin Kumar Singh4, Sagar Kumar5 and Rashmi Mittal5,* INTRODUCTION PROGNOSTIC AND PREDICTIVE POTENTIAL OF HISTOLOGIC SUBTYPING IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC AND PREDICTIVE POTENTIAL OF LYMPH NODE STATUS IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC ROLE OF LYMPHOVASCULAR INVASION IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC POTENTIAL OF MIRNA IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC POTENTIAL OF KI-67 IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC AND PREDICTIVE ROLE OF TUMOR-INFILTRATING LYMPHOCYTES IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC IMPLICATIONS OF BRCANESS IN TRIPLE NEGATIVE BREAST CANCER PROGNOSTIC IMPLICATIONS OF P53 IN TRIPLE NEGATIVE BREAST CANCER CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS ABBREVIATIONS REFERENCES Stumbling Blocks in Reinvigorating the Health of Diseased Individuals Through Herbal Medicine Acharya Balkrishna1, 2, Rashmi Mittal1 and Vedpriya Arya1,* INTRODUCTION DIFFICULTY IN THE IDENTIFICATION OF POTENTIAL DRUG CANDIDATES AGAINST TNBC CONSUMER'S PREFERENCE TOWARDS IMPLICATIONS OF HERBAL MEDICINE AGAINST TNBC BIOPHARMACEUTICS CONSIDERATION OF HERBAL MEDICINE AGAINST TNBC IMPACT OF PHARMACEUTICAL ENVIRONMENT ON EFFICACY OF THESE PHYTOCHEMICALS CHANGES IN REGULATORY PROCEDURES OF HERBAL MEDICINE WORLDWIDE CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Subject Index Back Cover
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