The stem cell hope : how stem cell medicine can change our lives

Oxidative-Reductionist Approaches to Stem and Progenitor Cell Function......Page 2
References......Page 3
Aging by Telomere Loss Can Be Reversed......Page 4
References......Page 5
HGPS-Derived iPSCs For The Ages......Page 6
References......Page 8
A Roundabout Way to the Niche......Page 9
References......Page 10
There and Back Again: Hair Follicle Stem Cell Dynamics......Page 11
References......Page 12
Transition of Endothelium to Cartilage and Bone......Page 13
References......Page 14
The Path to the Birth of the First IVF Babies......Page 15
Clinical IVF, hESCs, Science, and Society......Page 16
References......Page 17
DNA-Damage Response......Page 19
Diversity of DNA Repair Mechanisms in Tissue-Specific Stem Cells......Page 20
Hematopoietic SCs......Page 22
Melanocyte SCs......Page 24
Intestinal SCs......Page 25
Germline SCs......Page 26
CSCs in Leukemia......Page 27
CSCs in Glioblastoma......Page 28
References......Page 29
Introduction......Page 33
Characterization of iPSCs......Page 35
Impact of the HGPS Mutation on Fibroblast, Neural Progenitor, Endothelial, and MSC Functions under Normal Culture Conditions......Page 36
Patient iPSC-Derived VSMCs and MSCs Show Functional Defects under Stress......Page 39
Discussion......Page 41
Knockdown of Progerin in HGPS-iPS-MSCs by Lentiviral Infection......Page 45
References......Page 46
Introduction......Page 48
Calcineurin-NFAT Signaling Is Activated upon ESC Differentiation......Page 49
NFAT Directly Activates Src Expression......Page 51
Src Is Required for Calcineurin-NFAT-Induced ESC Differentiation......Page 52
NFAT-Src-Mediated EMT Is an Essential Step for Lineage Specification......Page 53
The Calcineurin-NFAT Signaling Cascade Is Indispensable for Early Embryo Development......Page 55
Cell Culture and Differentiation......Page 57
References......Page 58
Introduction......Page 61
Elevated ROS Enriches for Self-Renewing Neural Stem and Progenitor Cells in Clonal Neurosphere Cultures from Different Spec .........Page 62
Elevated ROS Levels and NOX Signaling Are Associated with Increased NSC Enrichment......Page 63
ROS Augments Growth and Trophic Factor Stimulation and Is Required for Normal NSC Self-Renewal......Page 64
NOX-Generated ROS Regulates SVZ Proliferation and Neurogenesis In Vivo......Page 65
Reactive Oxygen Species Regulate Neural Stem Cell Function......Page 68
The Effects of ROS-Mediated PI3K Pathway Signaling Are Context Dependent......Page 70
References......Page 71
Introduction......Page 74
Robo4−/− HSCs Display Poor BM Engraftment, but Normal Differentiation Capacity......Page 75
HSCs Lacking Robo4 Mobilize Less Efficiently with Cy/G Treatment......Page 76
Inhibition of Cxcr4 Restores Cy/G-Induced HSC Mobilization Efficiency in Robo4−/− Mice......Page 77
HSCs Express Relatively Low Levels of Cxcr4 and Migrate Less Efficiently toward Sdf1......Page 78
Robo4 and Cxcr4 Cooperate to Localize HSCs to the BM upon Transplantation......Page 79
Robo4 Regulates HSC Interactions with BM Niches......Page 80
Differential Efficacy of Cxcr4 Manipulation on Hematopoietic Stem and Progenitor Cells......Page 81
Receptor Redundancy in the Control of HSC Function......Page 82
References......Page 83
Introduction......Page 86
Damage or Infection of the Midgut Induces EGFR Signaling......Page 87
EGFR Activates ISCs through RAS/RAF/MAPK Signaling......Page 88
EGFR Signaling Is Required for ISC Proliferation and Midgut Regeneration......Page 89
Multiple EGFR Ligands Function Redundantly to Activate ISC Proliferation......Page 90
EGFR Signaling Is Required for ISC Proliferation Induced by Jak/Stat Signaling......Page 92
EGFR Signaling Is Essential for ISC Growth and Division......Page 93
Fly Genetics......Page 95
References......Page 96
Introduction......Page 98
Activating Chromatin Marks Are Targeted to Promoters prior to Transcriptional Activation......Page 99
Enhancer Signatures Are Driven from a Somatic toward an ESC-like State......Page 101
Discussion......Page 105
References......Page 106
Introduction......Page 108
Large Regions of CNV in hESCs and hiPSCs......Page 109
Recurrent Regions of CNV in hESCs and hiPSCs......Page 110
Duplications of Pseudogenes of Pluripotency-Associated Genes......Page 111
Dynamic Changes in Genomic Structure in hPSC Populations......Page 113
Genomic Aberrations during Reprogramming and Passage of hiPSCs......Page 114
Genomic Aberrations Arising during Differentiation......Page 115
Discussion......Page 117
Acknowledgments......Page 118
References......Page 119
In Vivo Fate Mapping and Expression Analysis Reveals Molecular Hallmarks of Prospectively Isolated Adult Neural Stem Cells......Page 121
Signaling the Niche......Page 122
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