The Search for Antiviral Drugs: Case Histories from Concept to Clinic

Front Matter....Pages i-xiii
Introduction: The First Effective Antiviral....Pages 1-21
Discovery and Development of Zidovudine as the Cornerstone of Therapy to Control Human Immunodeficiency Virus Infection....Pages 23-43
Discovery of Nevirapine, a Nonnucleoside Inhibitor of HIV-1 Reverse Transcriptase....Pages 45-70
Discovery of TIBO, a New Family of HIV-1-Specific Reverse Transcriptase Inhibitors....Pages 71-104
Discovery and Development of 2-Pyridinone HIV-1 Reverse Transcriptase Inhibitors....Pages 105-127
Discovery and Development of the HIV Proteinase Inhibitor Ro 31-8959....Pages 129-151
A New Approach to Antiviral Chemotherapy: Intervention in Viral Gene Expression by HIV Tat Antagonists....Pages 153-177
Discovery of Pirodavir, a Broad-Spectrum Inhibitor of Rhinoviruses....Pages 179-209
sICAM-1 as a Receptor Antagonist for Rhinoviruses: A Model System of Adhesion Molecules as Cell Receptors for Viruses....Pages 211-223
Inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors: A Potential Antiviral Strategy....Pages 225-238
Back Matter....Pages 239-240