The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium (Advances in Anatomy, Embryology and Cell Biology, 233)

Abstract
Acknowledgements
Contents
About the Authors
List of Abbreviations
Chapter 1: The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium
	1.1 Pulmonary Sensory Receptors
		1.1.1 Sensory Nerves in the Airways
		1.1.2 Intrapulmonary Myelinated Vagal Sensory Airway Receptors
		1.1.3 Why Focussing on the Pulmonary Neuroepithelial Body (NEB) Microenvironment (ME)?
	1.2 The Pulmonary NEB ME Is a Complex Intraepithelial Unit
		1.2.1 Components of the NEB ME
			1.2.1.1 Pulmonary Neuroendocrine Cells (PNECs)
			1.2.1.2 Clara-Like Cells (CLCs)
			1.2.1.3 Innervation of the NEB ME
		1.2.2 Receptor-Effector Properties of the Pulmonary NEB ME
	1.3 Studying the Pulmonary NEB ME: A Multidisciplinary Approach
		1.3.1 Functional Morphological Characteristics of the NEB ME
		1.3.2 Genetically Engineered Mouse Models to Study the NEB ME
		1.3.3 3D-Imaging and -Analysis of NEBs in Airway Whole Mount and in Cleared Whole Lungs
		1.3.4 Models and Techniques for Functional Live Cell Imaging (LCI) of the NEB ME
		1.3.5 Laser Microdissection and Selective Gene Expression Analysis of the NEB ME
	1.4 Functional Exploration of the Pulmonary NEB ME
		1.4.1 Mechanosensing in the NEB ME
		1.4.2 Chemosensing in the NEB ME
			1.4.2.1 Oxygen Sensing in the NEB ME
			1.4.2.2 Activation of the NEB ME by Cigarette Smoke and Nicotine
			1.4.2.3 Sensing Extracellular Ca2+ in the NEB ME
			1.4.2.4 Hypercapnia and H+ Sensing
		1.4.3 The Pulmonary NEB ME: A Unique Stem Cell Niche in the Airway Epithelium?
			1.4.3.1 The NEB ME During Lung Development and After Airway Injury
				Ontogenetic Development and Importance of the NEB ME
				Importance of the NEB ME for Epithelial Regeneration After Injury
			1.4.3.2 Modification of the NEB ME Related to Perinatal and Postnatal Disorders
			1.4.3.3 Selective Gene Expression in the Postnatal NEB ME: Special Focus on Stem Cell Characteristics
			1.4.3.4 Selective Activation and Proliferation of a Quiescent Stem Cell Population in the NEB ME by Transient Acute Lung Infla...
			1.4.3.5 Silencing Stem Cells in the Healthy Pulmonary NEB ME: Involvement of BMP Signalling
	1.5 Concluding Remarks and Future Perspectives
Correction to: The Pulmonary Neuroepithelial Body Microenvironment
	Correction to: I. Brouns et al., The Pulmonary Neuroepithelial Body Microenvironment, Advances in Anatomy, Embryology and Cell...
Addendum
References