The Prospect of Industry 5.0 in Biomanufacturing

Cover
Half Title
Title Page
Copyright Page
Contents
Preface
Editors
Contributors
1.1. Industrial Revolution 1.0 and 2.0
	1.1.1 Industrial Revolution 1.0
	1.1.2 Industrial Revolution 2.0
	1.1.3 Technology Development in Industrial 1.0 and 2.0
		1.1.3.1 Textile
		1.1.3.2 Steam Engine
		1.1.3.3 Iron Production
		1.1.3.4 Chemicals
		1.1.3.5 Electricity
		1.1.3.6 Transportation
		1.1.3.7 Agriculture and Food Engineering
	1.1.4 Industrialization beyond Britain
		1.1.4.1 Sweden
		1.1.4.2 United States
		1.1.4.3 Japan
		1.1.4.4 Belgium
	1.1.5 Social Effects of the Industrial Revolution
		1.1.5.1 Factories and Labors
		1.1.5.2 Social Effect for Women
		1.1.5.3 Urbanization
	1.1.6 Conclusion
	References
1.2. Industry 3.0
	1.2.1 From Industry 1.0 to Industry 3.0
	1.2.2 Era of Modern Genetic Engineering
	1.2.3 What Is Biomanufacturing?
	1.2.4 Fermenter - The Primary Workhorse of Biomanufacturing
		1.2.4.1 Continuous Stirred-Tank Fermenter
		1.2.4.2 Bubble Column Fermenter
		1.2.4.3 Airlift Fermenter
		1.2.4.4 Packed Bed Fermenter
		1.2.4.5 Fluidized Bed Fermenter
		1.2.4.6 Membrane Fermenter
		1.2.4.7 Fermenter-Type Photobioreactor
	1.2.5 Modeling of Bioreactor and Fermentation
	1.2.6 Biotechnology Entrepreneurship
	1.2.7 Biotechnology Product Sectors
	1.2.8 Conclusions
	References
1.3. Industry 4.0
	1.3.1 Introduction
	1.3.2 Key Technologies for IR 4.0
		1.3.2.1 Simulation
		1.3.2.2 Industrial Internet of Things (IIoT)
		1.3.2.3 Cybersecurity
		1.3.2.4 The Cloud
		1.3.2.5 Additive Manufacturing
		1.3.2.6 Augmented Reality
			1.3.2.6.1 Other Areas of Applied Technology
		1.3.2.7 Big Data and Analytics
		1.3.2.8 Autonomous Robots
		1.3.2.9 Horizontal and Vertical System Integration
			1.3.2.9.1 Horizontal Integration IR 4.0
			1.3.2.9.1.1 Horizontal Integration Strategies
			1.3.2.9.1.2 Vertical Integration IR 4.0
			1.3.2.9.1.3 Vertical Integration Strategies
	1.3.3 Biomanufacturing of Industry Revolution 4.0
		1.3.3.1 Food and Beverage
		1.3.3.2 Medicine
		1.3.3.3 Industrial Applications
	1.3.4 Challenges
	1.3.5 Future Perspectives
	References
2.1. What Is Industry 5.0?
	2.1 What Is Industry 5.0?
		2.1.1.1 The Implementation of a New Industrial Revolution
		2.1.1.2 The Differences in Industry 5.0 Compared to Other Industries
		2.1.1.3 The Challenges Faced to Adapt in a New Era
		2.1.1.4 The Benefits of Industry 5.0 in Application
		2.1.1.5 What Is Bio-manufacturing?
		2.1.1.6 Integration of Bio-manufacturing with New Industry Era 5.0
		2.1.1.7 Job Scope Revolution in Industry 5.0 Era
	2.1.2 Concepts and Possibilities
		2.1.2.1 The Advances in Artificial Intelligence (AI), Machine Learning (ML), and Deep Learning (DL) in Creating New Evolutional Businesses in Different Majors and in Bio-manufacturing
			2.1.2.1.1 Artificial Intelligence (AI) Technology
			2.1.2.1.2 Machine Learning (ML)
			2.1.2.1.3 Deep Learning (DL)
		2.1.2.2 The Advances in the Internet of Things (IoT) in Industry 5.0 Era on Bio-manufacturing Products
		2.1.2.3 The Advances in Nano, Bio-technology, and 3D Printing in Creating New Evolutional Products in Bio-manufacturing Industries
			2.1.2.3.1 Nanotechnology
			2.1.2.3.2 Biotechnology
			2.1.2.3.3 3D Printing
		2.1.2.4 The Product\'s Production Rate in the Industry 5.0 Era on Bio-manufacturing and the Manufactured Product\'s Quality
		2.1.2.5 The Employer\'s Potential Adaptation in Industry 5.0 Era
	2.1.3 Prospects and Challenges
		2.1.3.1 Economic Perspective on Machines\' Initial Cost and Maintenance in the Long Run
		2.1.3.2 Business Perspective on Machines\' Initial Cost and Maintenance in the Long Run
		2.1.3.3 Credibility for the Transformation to Industry 5.0
		2.1.3.4 Degree of Acceptance in the Implementation of a New Industry
		2.1.3.5 Employability in Industry 5.0 Era
			2.1.3.5.1 Networking
			2.1.3.5.2 Referrals
			2.1.3.5.3 Job Boards and Career Websites
			2.1.3.5.4 Job Fairs
	References
2.2. Significance of Industry 5.0
	2.2.1 Importance of Industrial Revolution
		2.2.1.1 Importance of Industry 5.0
	2.2.2 Healthcare, Medicine and Pharmaceuticals
	2.2.3 Food Supply
	2.2.4 Fuels and Biofuels
	2.2.5 Fine Chemicals and Biopolymers
	2.2.6 Manufacturing
	2.2.7 IT and Communications
	2.2.8 Supply Chain and Logistics
	2.2.9 Sustainable Economy
	2.2.10 Business
	2.2.11 Job and Labor Market
	2.2.12 Transportation
	2.2.13 Human Welfare and Equalities
	2.2.14 Environment and Climate Change
	2.2.15 Conclusion
	References
2.3. Transition of Bio-manufacturing Industry from 4.0 to 5.0: Advances and Challenges
	2.3.1 Introduction
	2.3.2 Bio-manufacturing Transformation from 4.0 to 5.0
	2.3.3 Bio-manufacturing Transformation Drivers in Industry 5.0
	2.3.4 Progression Methods
		2.3.4.1 Cell-Based Bio-manufacturing Methods
		2.3.4.2 Cell-Free Bio-manufacturing Methods
		2.3.4.3 Digital Bio-manufacturing Method
	2.3.5 Challenges and Issues with Industry 4.0-5.0 Transformation
		2.3.5.1 Manpower Requirement
		2.3.5.2 Optimization of Process Parameters
		2.3.5.3 Production of Bio-intelligent Materials
		2.3.5.4 In-vitro Metabolic Engineering
	2.3.6 Bio-manufacturing Industry Transformation from Synthetic to Bio-intelligent Synthetic Systems
		2.3.6.1 Bio-hybrid Electronic Devices
		2.3.6.2 Bioplastic
		2.3.6.3 Biosensors
		2.3.6.4 Novel Pharmaceuticals
		2.3.6.5 Biomimetic and Soft Robotics
		2.3.6.6 Tissue Engineering
		2.3.6.7 Biomass-Based Green Energy Systems
		2.3.6.8 Bioreactors
	2.3.7 Conclusions
	Acknowledgments
	References
3.1. Medicine and Pharmaceuticals Biomanufacturing - Industry 5.0
	3.1.1 Introduction
	3.1.2 Progression and Developments
	3.1.3 Advances in Technology
		3.1.3.1 Digitalization of Clinical Trials
		3.1.3.2 Cryptopharmaceuticals
		3.1.3.3 Human Bionics
	3.1.4 Manufacturing Process
		3.1.4.1 Advances on the Factory Floor
		3.1.4.2 On-Demand Agile Manufacturing and Personalization
	3.1.5 Digital Therapeutics
	3.1.6 Challenges
		3.1.6.1 Ethical Issues
		3.1.6.2 Challenges in Data Processing
		3.1.6.3 Designing for Human-Computer Interactions
		3.1.6.4 Job Security
	3.1.7 Future Prospects
	3.1.8 Conclusion
	References
3.2. Food and Beverage Bio-manufacturing - Industry 5.0
	3.2.1 Introduction
	3.2.2 Current Trends and Developments
		3.2.2.1 Digitalization of the Food Processing and Manufacturing Industry
		3.2.2.2 Augmented Reality
		3.2.2.3 Customization and Personalization
		3.2.2.4 Quality Control
		3.2.2.5 Genetic Engineering and Systems Metabolic Engineering
	3.2.3 Challenges and Future Developments
		3.2.3.1 Network Failures
		3.2.3.2 Job Security
		3.2.3.3 Customer Preferences and Lifestyle Changes
		3.2.3.4 Technological Advancements and Drawbacks
	3.2.4 Conclusion
	References
3.3. Fuel and Biofuels: Incorporation of Industry 5.0 to Biofuel Industry
	3.3.1 Introduction
	3.3.2 Fuel
	3.3.3 Biofuels
		3.3.3.1 Biodiesel
		3.3.3.2 Green Diesel
		3.3.3.3 Biogas
		3.3.3.4 Bioethanol
		3.3.3.5 Bio-oil, Bio-char and Syngas
	3.3.4 Industry 5.0 in Biofuel Production
		3.3.4.1 Conversion of Waste into Valuable Biofuel
		3.3.4.2 Genetic Engineering
		3.3.4.3 Extremophiles
	3.3.5 Conclusion
	Acknowledgements
	References
3.4. Application of Industry 5.0 on Fruit and Vegetables Processing
	3.4.1 Introduction
	3.4.2 Issues and Challenges
		3.4.2.1 Climate Change
		3.4.2.2 Storage and Transportation
		3.4.2.3 Processing Technology
		3.4.2.4 By-products
	3.4.3 Trends and Applications
		3.4.3.1 Intelligent Manufacturing
		3.4.3.2 Smart Grading and Assessment Systems
		3.4.3.3 Traceability and Authenticity Systems
		3.4.3.4 Personalization
		3.4.3.5 Bioeconomy
	3.4.4 Conclusions
	References
3.5. Application of Industry 5.0 in the Production of Fine Chemicals and Biopolymers
	3.5.1. Introduction
	3.5.2. Progression and Developments
		3.5.2.1. White Biotechnology
		3.5.2.2. Evolutionary Algorithms
		3.5.2.3. Synthetic Biology
	3.5.3. Advantages of IR 5.0 in the Production of Fine Chemicals and Biopolymers
		3.5.3.1. Data Sensor Network
	3.5.3.2. Visualization and Modelling of Production Line
		3.5.3.3. Intelligent Autonomous Systems for Manufacturing Lines
	3.5.4. Challenges, Perspectives and Future Prospects
		3.5.4.1. Societal Challenges
		3.5.4.2. Challenges in Industrialization
		3.5.4.3. Future Prospects
	3.5.5. Conclusions
	References
4.1. State-of-the-Art Technologies in Industry 5.0
	4.1.1 Introduction
	4.1.2 Role of Biomanufacturing in Bioeconomy
	4.1.3 Supercritical Fluid Technology
	4.1.4 Enzymatic Pretreatment and Activation
	4.1.5 Biological Membrane Synthesis
	4.1.6 Bioalcohol Recovery
	4.1.7 Algae Technology
	4.1.8 Bioenergy Production
		4.1.8.1 Lipid Production
		4.1.8.2 Algae Derived Bioalcohol Production
		4.1.8.3 Biohydrogen Production
	4.1.9 Biorefinery Integration Paradigm
	4.1.10 Conclusion
	Acknowledgement
	References
4.2. Sustainability and Development of Industry 5.0
	4.2.1 Sustainable Processes in Biomanufacturing
		4.2.1.1 Principles of Biomanufacturing
		4.2.1.2 DNA Sequencing, the Onset of Systematic Biomanufacturing
		4.2.1.3 Protein Synthesis through Central Dogma
		4.2.1.4 Synthesis of Metabolites
		4.2.1.5 The Harvesting of End Product
	4.2.2 Development of Automated Systems and Novel Technologies
		4.2.2.1 Synthetic Biology
		4.2.2.2 High Throughput and Automation in Processing
		4.2.2.3 Breakthrough of CRISPR-Cas9
	4.2.3 Towards a Cleaner Environment
	4.2.4 Concluding Remarks
	References
5.0. Industrial Perspective of Industry 5.0
	5.0.1 What Are the Most Apparent Changes in IR 5.0 from IR 4.0?
	5.0.2 What Is the Demand from the Community That Can Make IR 5.0 Successful from an Industrial Scale?
	5.0.3 How Can IR 5.0 Be Implemented in the Industry While Maintaining a Good Cost-Benefit Margin?
	5.0.4 How Much Will Industries Be Willing to Adapt and Change to IR 5.0?
	References
Index