The Pathobiology of Neoplasia

Front Matter....Pages i-xxii
Introduction Chronology of Significant Events in the Study of Neoplasia....Pages 1-24
Classification of Neoplasms....Pages 25-38
Chemical Carcinogenesis in Experimental Animals and Humans....Pages 39-56
DNA Adducts and Carcinogenesis....Pages 57-80
Oncogenic Viruses....Pages 81-109
Radiation Carcinogenesis....Pages 111-129
The Multistage Concept of Carcinogenesis....Pages 131-148
Organ and Species Specificity in Chemical Carcinogenesis and Tumor Promotion....Pages 149-171
DNA Repair Mechanisms and Carcinogenesis....Pages 173-197
Preneoplasia and Precancerous Lesions....Pages 199-215
Tumor Progression and the Clonal Evolution of Neoplasia....Pages 217-229
Cytogenetics and Human Neoplasia....Pages 231-246
Genetics of Susceptibility to Mouse Skin Tumor Promotion....Pages 247-274
Oncogenes....Pages 275-290
Activation of Oncogenes by Chemical Carcinogens....Pages 291-304
Alterations in Biochemical Control Mechanisms of Neoplastic Cells....Pages 305-322
Membrane Alterations in Neoplasia....Pages 323-344
Growth Factors and Neoplasia....Pages 345-370
Biochemical Mechanisms of Action of the Phorbol Ester Class of Tumor Promoters....Pages 371-383
Biochemical Marker Alterations in Hepatic Preneoplasia and Neoplasia....Pages 385-397
Oncogene Activation and Expression during Carcinogenesis in Liver and Pancreas....Pages 399-417
Oncodevelopmental Expression and Neoplasia....Pages 419-434
Expression of Differentiated Function in Neoplasms....Pages 435-460
Ectopic Hormone Production and Neoplasia....Pages 461-475
Metaplastic Transformation of Pancreatic Cells to Hepatocytes....Pages 477-495
Crown Gall Neoplasms....Pages 497-512
Angiogenesis....Pages 513-531
Tumor Invasion and Metastases....Pages 533-546
Phenotypic Heterogeneity and Metastasis....Pages 547-572
Back Matter....Pages 573-583