The Neuropharmacology of Alcohol

Front Matter ....Pages i-xi
Front Matter ....Pages 1-1
 GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence  (Cassie M. Chandler, John S. Overton, Daniela Rüedi-Bettschen, Donna M. Platt)....Pages 3-27
 Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking  (David M. Lovinger)....Pages 29-54
 Dynamic Adaptation in Neurosteroid Networks in Response to Alcohol  (Deborah A. Finn, Vanessa A. Jimenez)....Pages 55-78
 GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum  (Verginia C. Cuzon Carlson)....Pages 79-112
 The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder  (David J. Rossi, Ben D. Richardson)....Pages 113-156
 Do Alcohol-Related AMPA-Type Glutamate Receptor Adaptations Promote Intake?  (F. Woodward Hopf, Regina A. Mangieri)....Pages 157-186
 Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions  (Paul M. Klenowski, Andrew R. Tapper)....Pages 187-212
 Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure  (Cody A. Siciliano, Anushree N. Karkhanis, Katherine M. Holleran, James R. Melchior, Sara R. Jones)....Pages 213-238
 Central Noradrenergic Interactions with Alcohol and Regulation of Alcohol-Related Behaviors  (Elena M. Vazey, Carolina R. den Hartog, David E. Moorman)....Pages 239-260
Front Matter ....Pages 261-261
 Voltage-Sensitive Calcium Channels in the Brain: Relevance to Alcohol Intoxication and Withdrawal  (Prosper N’Gouemo)....Pages 263-280
 Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons  (Alex M. Dopico, Anna N. Bukiya, Jill C. Bettinger)....Pages 281-309
 Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior  (Reginald Cannady, Jennifer A. Rinker, Sudarat Nimitvilai, John J. Woodward, Patrick J. Mulholland)....Pages 311-343
Front Matter ....Pages 345-345
 Hepatic Immune System: Adaptations to Alcohol  (Adam Kim, Rebecca L. McCullough, Kyle L. Poulsen, Carlos Sanz-Garcia, Megan Sheehan, Abram B. Stavitsky et al.)....Pages 347-367
 Innate Immune Signaling and Alcohol Use Disorders  (Leon G. Coleman Jr., Fulton T. Crews)....Pages 369-396
 Ethanol and Cytokines in the Central Nervous System  (Marisa Roberto, Reesha R. Patel, Michal Bajo)....Pages 397-431
Front Matter ....Pages 433-433
 Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking  (Allyson L. Schreiber, Nicholas W. Gilpin)....Pages 435-471
 Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol  (Rachel I. Anderson, David E. Moorman, Howard C. Becker)....Pages 473-503
 Transcriptional Regulators as Targets for Alcohol Pharmacotherapies  (Antonia M. Savarese, Amy W. Lasek)....Pages 505-533
Front Matter ....Pages 535-535
 Advancing Pharmacotherapy Development from Preclinical Animal Studies  (Mark Egli)....Pages 537-578
 Advances in Pharmacotherapy Development: Human Clinical Studies  (Raye Z. Litten, Daniel E. Falk, Megan L. Ryan, Joanne Fertig, Lorenzo Leggio)....Pages 579-613
 Correction to: GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence  (Cassie M. Chandler, John S. Overton, Daniela Rüedi-Bettschen, Donna M. Platt)....Pages 615-615
 Correction to: Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking  (David M. Lovinger)....Pages 617-617
 Correction to: Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior  (Reginald Cannady, Jennifer A. Rinker, Sudarat Nimitvilai, John J. Woodward, Patrick J. Mulholland)....Pages 619-619
 Correction to: Innate Immune Signaling and Alcohol Use Disorders  (Leon G. Coleman Jr., Fulton T. Crews)....Pages 621-621
 Correction to: Transcriptional Regulators as Targets for Alcohol Pharmacotherapies  (Antonia M. Savarese, Amy W. Lasek)....Pages 623-624
 Correction to: Advancing Pharmacotherapy Development from Preclinical Animal Studies  (Mark Egli)....Pages 625-625