The Marathon of the Messenger: A History of Messenger RNA Vaccines

About the Authors
Acknowledgements
Contents
Foreword
Preface
Introduction: The Marathon of the Messenger RNA…
Part I Messenger RNA, An Essential Role and Challenge
1 A Short History of Vaccination
	References
2 From DNA to RNA
	2.1 The Skeleton of DNA and RNA
	References
3 Messenger RNA (mRNA): From Transcription to Protein Translation
4 The Mechanism of Viral Infection
	4.1 The AIDS Virus and New Viruses
5 The Immune Response
	5.1 The Role of Cytokines
	5.2 Facilitating Antibodies
	References
Part II From Preliminary Studies to Clinical Trials
6 Promising Studies in the 1990s
	References
7 The Use of mRNA—The Initial Technical Obstacles
	References
8 The Birth of CureVac: The Era of the Pioneers
	References
9 Solutions for mRNA Optimization
	References
10 Modified and Unmodified mRNA: For What Purpose?
	References
11 Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA
	References
12 Experiments and Clinical Trials Against Infectious Diseases
	12.1 The Role of Type 1 Interferon in Triggering the Adaptive Immune Response
	References
13 Experiments and Clinical Trials Against Cancer
	13.1 Additional Information on Experiments and Clinical Trials Carried Out Against Cancers
	References
14 Experiments and Clinical Trials Carried Out in Other Therapeutic Fields
	References
15 Modified mRNA Versus Unmodified mRNA: Not just a Scientific Issue
	References
Part III The Triumph of Messenger RNA
16 A Very Progressive Diffusion in Scientific Circles
	16.1 Publish High or Publish Safe?
	References
17 The Development of Great mRNA Biotechs in the 2010s
	References
18 The Importance of Intellectual Property and Patents
	References
19 2020: The Triumph of Anti-Covid mRNA Vaccines
	19.1 Additional Data on Anti-Covid mRNA Vaccines
	References
20 mRNA, a Technology of the Future
	References
Conclusion
Postfaces
Afterword by Chantal Pichon
Afterword by Steve Pascolo
Glossary