The Chemistry and Biology of Beta-Lactams

Cover
Half Title
Title Page
Copyright Page
About the Author
Table of Contents
Abbreviations
Acknowledgments
Preface
1. β-Lactams and Antibiotics
	1.1 Brief Introduction
	1.2 Penicillin Antibiotics
	1.3 Cephalosporin Antibiotics
	1.4 Carbapenem Antibiotics
	1.5 Monobactam Antibiotics
	1.6 Clavam Antibiotics
	1.7 Miscellaneous β-Lactam Antibiotics
	Keywords
	References
2. Antimicrobial Activity of β-Lactams and Bacterial Resistance
	2.1 Brief Introduction of Bacteria
	2.2 Nomenclature and Classification of Bacteria
	2.3 Antibacterial Mechanism
	2.4 Resistance of Antibacterial Activity
	2.5 Mechanisms for Antibiotics Resistance
	2.6 β-Lactamases Databases
	2.7 Other Biological Activities of β-Lactams
	Keywords
	References
3. Synthetic Methods of β-Lactams
	3.1 Brief Introduction
	3.2 Formation of β-Lactams Through Cycloadditions
	3.3 Intramolecular Substitutive Cyclization
	3.4 Enzymatic Synthesis of β-Lactams
	3.5 Miscellaneous Methods
	Keywords
	References
4. Reactions of β-Lactams
	4.1 Brief Introduction
	4.2 Cleavage of the Amide Bond of β-Lactams
	4.3 Preparation of Polyamides
	4.4 Application in the Synthesis of Unnatural α-Amino Acid Derivatives and Relating Peptides
	4.5 Nucleophilic Substitution on C3 or C4
	4.6 Cleavage of C3-C4 Bond
	4.7 Cleavage of N1-C4 Bond
	4.8 Function at N1
	Keywords
	References
Index