The Calcium Channel: Structure, Function and Implications: Stresa/Italy, May 11–14, 1988

Front Matter....Pages I-XXVII
History and Philosophy of Bayer Pharmaceutical Research....Pages 1-8
The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882....Pages 9-15
Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships....Pages 16-34
Front Matter....Pages 37-37
Kinetics and β-Adrenergic Modulation of Cardiac Ca 2+ Channels....Pages 39-53
Dihydropyridines, G Proteins, and Calcium Channels....Pages 54-62
Electrophysiology of Dihydropyridine Calcium Agonists....Pages 63-70
Proton-Induced Transformation of Ca 2+ Channel: Possible Mechanism and Physiological Role....Pages 71-80
Membrane Potential and Dihydropyridine Block of Calcium Channels in the Heart: Influence of Drug Ionization on Blocking Activity....Pages 81-91
Dihydropyridine-Sensitive and -Insensitive Ca 2+ Channels in Normal and Transformed Fibroblasts....Pages 92-102
Protein Phosphorylation and the Inactivation of Dihydropyridine-Sensitive Calcium Channels in Mammalian Pituitary Tumor Cells....Pages 103-114
Sodium Currents Through Neuronal Calcium Channels: Kinetics and Sensitivity to Calcium Antagonists....Pages 115-127
Block of Sodium Currents Through a Neuronal Calcium Channel by External Calcium and Magnesium Ions....Pages 128-137
The Voltage Sensor of Skeletal Muscle Excitation-Contraction Coupling: A Comparison with Ca 2+ Channels....Pages 138-156
Front Matter....Pages 157-157
Biochemistry and Molecular Pharmacology of Ca 2+ Channels and Ca 2+ -Channel Blockers....Pages 159-167
The Structure of the Ca 2+ Channel: Photoaffinity Labeling and Tissue Distribution....Pages 168-192
Site-Specific Phosphorylation of the Skeletal Muscle Receptor for Calcium-Channel Blockers by cAMP-Dependent Protein Kinase....Pages 193-199
Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle....Pages 200-210
Molecular Characterization of the 1,4-Dihydropyridine Receptor in Skeletal Muscle....Pages 211-216
Reconstitution of Solubilized and Purified Dihydropyridine Receptor from Skeletal Muscle Microsomes as Two Single Calcium Channel Conductances with Different Functional Properties....Pages 217-230
1,4-Dihydropyridines as Modulators of Voltage-Dependent Calcium-Channel Activity....Pages 231-251
Front Matter....Pages 157-157
Dihydropyridine Pharmacology of the Reconstituted Calcium Channel of Skeletal Muscle....Pages 252-271
Expression of mRNA Encoding Rat Brain Ca 2+ Channels in Xenopus Oocytes....Pages 272-280
Front Matter....Pages 281-281
Ca 2+ Pathways Mediating Agonist-Activated Contraction of Vascular Smooth Muscle and EDRF Release from Endothelium....Pages 283-292
Calcium Channels and the Heart....Pages 293-309
Role of Calcium Channels in Cardiac Arrhythmias....Pages 310-316
General Anaesthetics and Antiarrhythmics Antagonize the Ca 2+ Current in Single Frog Cardiac Cells....Pages 317-325
The Calcium Channel and Vascular Injury....Pages 326-334
Endocrine Effects of Calcium Channel Agonists and Antagonists in a Pituitary Cell System....Pages 335-346
L-Type Calcium Channels and Adrenomedullary Secretion....Pages 347-362
Regulation of Signal Transduction by G Proteins in Exocrine Pancreas Cells....Pages 363-371
Calcium Channel Blockers and Renin Secretion....Pages 372-393
Action of Parathyroid Hormone on Calcium Transport in Rat Brain Synaptosomes is Independent of cAMP....Pages 394-403
Calcium and the Mediation of Tubuloglomerular Feedbacks Signals....Pages 404-417
Inhibition of Parathyroid Hormone Secretion by Calcium: The Role of Calcium Channels....Pages 418-430
Front Matter....Pages 431-431
The Neuropharmacology of Ca 2+ Channels....Pages 433-441
Kinetic Characteristics of Different Calcium Channels in the Neuronal Membrane....Pages 442-464
Increased Calcium Currents in Rat Hippocampal Neurons During Aging....Pages 465-477
Regulation of Brain 1,4-Dihydropyridine Receptors by Drug Treatment....Pages 478-490
Nimodipine and Neural Plasticity in the Peripheral Nervous System of Adult and Aged Rats....Pages 491-502
Anticonvulsant Properties of Dihydropyridine Calcium Antagonists....Pages 503-519
Front Matter....Pages 431-431
Interaction Between Certain Antipsychotic Drugs and Dihydropyridine Receptor Sites....Pages 520-527
Effects of Organic Calcium-Entry Blockers on Stimulus-Induced Changes in Extracellular Calcium Concentration in Area CAl of Rat Hippocampal Slices....Pages 528-540
Alcohol, Neurodegenerative Disorders, and Calcium Channel Antagonist Receptors....Pages 541-546
Front Matter....Pages 547-547
Endogenous Ligands for the Calcium Channel: Myths and Realities....Pages 549-563
Endogenous 1,4-Dihydropyridine-Displacing Substances Acting on L-Type Ca 2+ Channels: Isolation and Characterization of Fractions from Brain and Stomach....Pages 564-574
Endothelium-Derived Novel Vasoconstrictor Peptide Endothelin: A Possible Endogenous Agonist for Voltage-Dependent Ca 2+ Channels....Pages 575-585
Ca 2+ Channel Antibodies: Subunit-Specific Antibodies as Probes for Structure and Function....Pages 586-600
Endogenous Ligands for Voltage-Sensitive Calcium Channels in Extracts of Rat and Bovine Brain....Pages 601-610
An Endogenous Purified Peptide Modulates Ca 2+ Channels in Neurons and Cardiac Myocytes....Pages 611-618
Antibodies Against the ADP/ATP Carrier Interact with the Calcium Channel and Induce Cytotoxicity by Enhancement of Calcium Permeability....Pages 619-631
Front Matter....Pages 633-633
Calcium Aging, and Diseases....Pages 635-639
Back Matter....Pages 640-643