The BlooddBrain Barrier and Drug Delivery to the CNS

 Content: History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain Michael W. Bradbury Physicochemical Factors that Influence Brain Uptake Michael H. Abraham and James A. Platts The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers Christiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helmut Franke, Matthias Haselbach, Joachim Wegener, and Hans-Joachim Galla In Vitro Models of the Blood-Brain Barrier and Their Use in Drug Development R. Cecchelli, B. Dehouck, L. Descamps, L. Fenart, V. Buee-Scherrer, C. Duhem, G. Torpier, and M. P. Dehouck The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain Barrier A. G. de Boer, Elizabeth C. M. de Lange, Inez C. J. van der Sandt, and Douwe D. Breimer The Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the Brain David J. Begley, Anthony Regina, Francoise Roux, Ehsan Ullah Khan, Christopher Rollinson, and Joan Abbott The Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model System Ulrich Mayer Specific Mechanisms for Transporting Drugs Into Brain Akira Tsuji Drug Metabolism in the Brain: Benefits and Risks Alain Minn, Ramon D. S. El-Bacha, Claire Bayol-Denizot, Philippe Lagrange, Funmilayo G. Suleman, and Daniela Gradinaru Targeting Macromolecules to the Central Nervous System Ulrich Bickel Using Nanoparticles to Target Drugs to the Central Nervous System Jorg Kreuter and Renad N. Alyautdin Basic CNS Drug Transport and Binding Kinetics In Vivo Albert Gjedde, Antony D. Gee, and Donald Frederick Smith