The Ambivalence of Cytostatic Therapy

Front Matter....Pages I-VIII
The Carcinogenic Properties of Some of the Principal Drugs Used in Clinical Cancer Chemotherapy....Pages 1-17
Experimental Investigations with Anti-Cancer Drugs for Carcinogenicity with Special Reference to Immunedepression....Pages 18-28
Tests for Tumor Induction by Antitumor Agents....Pages 29-35
Adverse Reactions to Cytostatic Agents....Pages 36-41
The Changing Pattern of Hodgkin’s Disease Seen at Autopsy....Pages 42-49
Tumor Inductions by Cytostatics in Man....Pages 50-56
Methodological Problems in the Quantitative Assessment of Carcinogenesis in Long-Term Studies....Pages 57-61
Summary....Pages 62-64
Immune Suppression and Chemical Carcinogenesis....Pages 65-75
Experimental Investigations on Immunodepressive Properties of Carcinogenic Substances in Male Sprague-Dawley Rats....Pages 76-87
The Significance of Immunosuppression and Antigenic Stimulation in the Development of Malignant Lymphomas....Pages 88-95
Malignant Disease in Immunodeficient States in Man....Pages 96-106
The Effect of Cytostatic Therapy on Cellular Immunity in vitro ....Pages 107-113
The Balance of Host Immunocompetence in Chemical Carcinogenesis and “Nonspecific” Immunotherapy....Pages 114-136
Tumor Induction in Immunologically Privileged Sites....Pages 137-138
Patterns of Neoplastic and Nonneoplastic Diseases of Praomys (Mastomys) Natalensis....Pages 139-144
Summary....Pages 145-148
The Cell Cycle in Cancer Chemotherapy....Pages 149-155
Proliferative Parameters Relevant to Cancer Therapy....Pages 156-171
Different Types of DNA-Synthesis and Their Importance in Cancer Growth and Therapy....Pages 172-178
Investigations on Partial Synchronization in Ascites Tumors of Different Ploidy and in Solid Transplantable Tumors....Pages 179-186
Critical Survey of Experimental Data on in vivo Synchronization by Hydroxyurea....Pages 187-205
Cell Synchronization in Solid Tumors....Pages 206-214
Experimental and Clinical Results of Chemotherapy after Partial Synchronization of Cell Proliferation....Pages 215-224
Problems in the Treatment of Slow-Growing Tumors....Pages 225-233
Summary....Pages 234-236
Back Matter....Pages 237-246