Textbook of Pulmonary Vascular Disease

Front Matter....Pages i-xxxii
Front Matter....Pages 1-1
The Human Pulmonary Circulation: Historical Introduction....Pages 3-12
Microcirculation of the Lung: Functional and Anatomic Aspects....Pages 13-24
Pulmonary Vascular Development....Pages 25-60
Pulmonary Vascular Function....Pages 61-72
Pulmonary Vascular Mechanics....Pages 73-89
Modeling of the Pulmonary Vasculature....Pages 91-103
Metabolic and Clearance Function at the Pulmonary Microvascular Endothelial Surface in Pulmonary Hypertension....Pages 105-115
The Influence of the Major Vasoactive Mediators Relevant to the Pathogenesis of Pulmonary Hypertension....Pages 117-133
The Normal Fetal and Neonatal Pulmonary Circulation....Pages 135-146
Excitation–Contraction Coupling and Regulation of Pulmonary Vascular Contractility....Pages 147-165
Endothelial Regulation of Pulmonary Vascular Tone....Pages 167-195
Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers....Pages 197-222
Ion Channels and Transporters in the Pulmonary Vasculature: A Focus on Smooth Muscle....Pages 223-244
Receptor-Mediated Signal Transduction and Cell Signaling....Pages 245-260
Role of Calcium as a Second Messenger in Signaling: A Focus on Endothelium....Pages 261-272
Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells....Pages 273-285
The Chemistry of Biological Gases....Pages 287-299
Role of Oxygen-Derived Species in the Regulation of Pulmonary Vascular Tone....Pages 301-311
Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O 2 Sensing....Pages 313-322
Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation....Pages 323-334
Front Matter....Pages 1-1
Role of Ca 2+ in Vascular Smooth Muscle Gene Expression and Proliferation....Pages 335-346
Biochemistry and Cellular Mechanisms of Apoptosis in Vascular Smooth Muscle and Endothelial Cells....Pages 347-356
The Coagulation Cascade and Its Regulation....Pages 357-370
Platelets in Pulmonary Vascular Physiology and Pathology....Pages 371-384
Lysis and Organization of Pulmonary Thromboemboli....Pages 385-397
Interactions of Leukocytes and Coagulation Factors with the Vessel Wall....Pages 399-410
Interaction of the Plasminogen System with the Vessel Wall....Pages 411-424
Endothelial Apoptosis and Repair in Pulmonary Arterial Hypertension....Pages 425-438
Bronchial Arterial Circulation in the Human....Pages 439-450
Front Matter....Pages 451-451
Animal Models of Pulmonary Hypertension....Pages 453-458
Transgenic and Gene-Targeted Mouse Models for Pulmonary Hypertension....Pages 459-470
Animal Models of Increased Lung Vascular Permeability....Pages 471-484
Isolation and Culture of Pulmonary Vascular Smooth Muscle and Endothelial Cells....Pages 485-493
Conventional Patch Clamp Techniques and High-Throughput Patch Clamp Recordings on a Chip for Measuring Ion Channel Activity....Pages 495-510
Measurement of Pulmonary Vascular Structure and Pulmonary Blood Distribution by Multidetector-Row Computed Tomography and Magnetic Resonance Imaging Techniques....Pages 511-524
Quantification of DNA, RNA, and Protein Expression....Pages 525-537
Gene Cloning, Transfection, and Mutagenesis....Pages 539-555
Approaches for Manipulation of Gene Expression....Pages 557-566
Bioinformatics, Genomics, and Functional Genomics: Overview....Pages 567-580
Genomic Applications to Study Pulmonary Hypertension....Pages 581-590
Front Matter....Pages 451-451
Proteomics and Functional Proteomics....Pages 591-612
Maintenance, Propagation, and Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells....Pages 613-620
Identification of Adult Stem and Progenitor Cells in the Pulmonary Vasculature....Pages 621-636
Differentiation of Embryonic Stem Cells to Vascular Cell Lineages....Pages 637-650
Statistics and Clinical Data Analysis: A Reference Guide....Pages 651-672
Front Matter....Pages 673-673
Hypoxic Pulmonary Vasoconstriction....Pages 675-682
Pathogenic Roles of Ca 2+ and Ion Channels in Hypoxia-Mediated Pulmonary Hypertension....Pages 683-694
Roles of Endothelium-Derived Vasoactive and Mitogenic Factors in the Development of Chronic Hypoxia-Mediated Pulmonary Hypertension....Pages 695-711
Oxygen-Sensitive Transcription Factors and Hypoxia-Mediated Pulmonary Hypertension....Pages 713-723
Developmental Regulation of Pulmonary Vascular Oxygen Sensing....Pages 725-732
Pulmonary Vascular Remodeling by High Oxygen....Pages 733-758
Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms....Pages 759-777
Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure....Pages 779-786
Shear Stress, Cell Signaling, and Pulmonary Vascular Remodeling....Pages 787-799
Pulmonary Hypertension and the Extracellular Matrix....Pages 801-809
Role of Progenitor Cells in Pulmonary Vascular Remodeling....Pages 811-823
Receptor Signaling in Pulmonary Arterial Hypertension....Pages 825-836
Role of Endothelium in the Development of Pulmonary Hypertension....Pages 837-850
Coagulation and the Vessel Wall in Pulmonary Embolism....Pages 851-860
Alveolar Epithelial Fluid Transport in Lung Injury....Pages 861-870
Front Matter....Pages 673-673
High-Altitude Pulmonary Edema....Pages 871-888
Statins and Acute Lung Injury....Pages 889-898
Genomics of Acute Lung Injury and Vascular Barrier Dysfunction....Pages 899-912
Ventilator-Induced Mechanical Stress and Lung Vascular Dysfunction....Pages 913-934
Front Matter....Pages 935-935
Classification of Pulmonary Hypertension: History and Perspectives....Pages 937-942
Epidemiology of Pulmonary Arterial Hypertension....Pages 943-961
Air Pollution and the Pulmonary Vasculature....Pages 963-977
Idiopathic Pulmonary Arterial Hypertension....Pages 979-995
Genetics of Familial and Idiopathic Pulmonary Arterial Hypertension....Pages 997-1009
Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases....Pages 1011-1022
Pathology and Management of Portopulmonary Hypertension....Pages 1023-1031
Pathobiology and Treatment of Pulmonary Hypertension in HIV Disease....Pages 1033-1041
Pulmonary Arterial Hypertension Secondary to Anorexigens and Other Drugs and Toxins....Pages 1043-1059
Pulmonary Arterial Hypertension Related to Gaucher’s Disease, Sarcoidosis, and Other Disorders....Pages 1061-1081
Pediatric Pulmonary Hypertension: An Integrated View from Pediatric Subspecialists....Pages 1083-1108
Persistent Pulmonary Hypertension of the Newborn: Mechanisms and Treatment....Pages 1109-1118
The Pulmonary Circulation in Congenital Heart Disease....Pages 1119-1138
Pulmonary Hypertension Secondary to Congenital Systemic-to-Pulmonary (Left-to-Right) Shunts....Pages 1139-1151
Surgical Evaluation of Congenital-Heart-Disease-Associated Pulmonary Hypertension....Pages 1153-1168
Pulmonary Veno-occlusive Disease....Pages 1169-1181
Front Matter....Pages 935-935
Left Ventricular Diastolic Heart Function and Pulmonary Hypertension....Pages 1183-1188
Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Diseases....Pages 1189-1196
Pulmonary Hypertension Associated with Interstitial Lung Disease....Pages 1197-1210
High-Altitude Pulmonary Hypertension....Pages 1211-1221
Pulmonary Hypertension and Congenital Heart Defects at High Altitude....Pages 1223-1230
Pulmonary Embolism and Deep Vein Thrombosis....Pages 1231-1238
Pulmonary Hypertension Due to Pulmonary Embolism and Thromboembolic Obstruction of Proximal and Distal Pulmonary Arteries....Pages 1239-1251
Risk Factors for Chronic Thromboembolic Pulmonary Hypertension....Pages 1253-1259
Evaluation of Small-Vessel Arteriopathy in Chronic Thromboembolic Pulmonary Hypertension....Pages 1261-1267
Hemolytic-Anemia-Associated Pulmonary Hypertension: Sickle-Cell-Disease- and Thalassemia-Associated Pulmonary Hypertension....Pages 1269-1282
Pulmonary Hypertension Due to Schistosomiasis....Pages 1283-1296
Pulmonary Hypertension Due to Capillary Hemangiomatosis....Pages 1297-1304
Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease....Pages 1305-1312
Right Ventricular Dysfunction in Pulmonary Hypertension....Pages 1313-1331
Large Vessel Pulmonary Arteritis....Pages 1333-1342
Tumors of the Pulmonary Vascular Bed....Pages 1343-1353
Cor Pulmonale....Pages 1355-1376
Pregnancy and Contraception in Patients with Pulmonary Arterial Hypertension....Pages 1377-1384
Front Matter....Pages 1385-1385
Cardiac Catheterization in the Patient with Pulmonary Hypertension....Pages 1387-1402
Imaging of Pulmonary Vascular Diseases....Pages 1403-1412
Front Matter....Pages 1385-1385
Histological and Pathological Diagnosis of Pulmonary Hypertension: Pathological Classification of Pulmonary Vascular Lesions....Pages 1413-1423
Echocardiography in Pulmonary Vascular Disease....Pages 1425-1445
Calcium Channel Blockers in the Treatment of Pulmonary Arterial Hypertension....Pages 1447-1450
Prostacyclin and Prostaglandins....Pages 1451-1463
Endothelin Receptor Antagonists for the Treatment of Pulmonary Arterial Hypertension....Pages 1465-1475
Phosphodiesterase Inhibitors in the Treatment of Pulmonary Hypertension....Pages 1477-1485
Nitric Oxide for Children....Pages 1487-1500
The Serotonin System as a Therapeutic Target in Pulmonary Hypertension....Pages 1501-1507
Combination Therapy for Pulmonary Arterial Hypertension....Pages 1509-1520
Thrombolytic and Anticoagulant Therapy for Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension....Pages 1521-1539
Nursing Care of Patients with Pulmonary Arterial Hypertension....Pages 1531-1558
Atrial Septostomy....Pages 1561-1567
Evaluation of Patients with Chronic Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy....Pages 1569-1576
Pulmonary Endarterectomy....Pages 1577-1592
Evaluation of Patients with Pulmonary Hypertension for Lung Transplantation....Pages 1593-1598
Lung Transplantation for Pulmonary Hypertension....Pages 1599-1602
Living-Donor Lobar Lung Transplantation for Pulmonary Arterial Hypertension....Pages 1603-1611
Results of Lung Transplantation....Pages 1613-1626
Back Matter....Pages 1625-1658