Textbook of Biochemistry for Medical Students

Cover......Page 1
Preface......Page 6
Contents......Page 9
1. Biochemical Perspective to Medicine......Page 16
2. Subcellular Organelles and Cell Membranes......Page 22
3. Amino Acids Structure and Properties......Page 34
4. Proteins Structure and Function......Page 42
5. Enzymology General Concepts and Enzyme Kinetics......Page 55
6. Chemistry of Carbohydrates......Page 75
7. Chemistry of Lipids......Page 88
8. Overview of Metabolism......Page 98
9. Major Metabolic Pathways of Glucose......Page 105
10. Minor Metabolic Pathways of Carbohydrates......Page 128
11. Metabolism of Fatty Acids......Page 142
12. Cholesterol and Lipoproteins......Page 161
13. MCFA, PUFA, Prostaglandins and Compound Lipids......Page 175
14. General Amino Acid Metabolism (Urea Cycle, One Carbon Metabolism)......Page 185
15. Simple, Hydroxy and Sulfur Containing Amino Acids......Page 198
16. Acidic, Basic and Branched Chain Amino Acids......Page 209
17. Aromatic Amino Acids and Amino Acidurias......Page 218
18. Citric Acid Cycle......Page 231
19. Biological Oxidation and Electron Transport Chain......Page 238
20. Free Radicals and Anti-oxidants......Page 251
21. Heme Synthesis and Breakdown......Page 257
22. Hemoglobin......Page 269
23. Clinical Enzymology and Biomarkers......Page 281
24. Regulation of Blood Glucose, Insulin and Diabetes......Page 289
25. Cardiovascular Diseases and Hyperlipidemias......Page 307
26. Liver and Gastric Function Tests......Page 316
27. Kidney Function Tests......Page 329
28. Plasma Proteins......Page 344
29. Acid-Base Balance and pH......Page 354
30. Electrolyte and Water Balance......Page 370
31. Body Fluids (Milk, CSF, Amniotic Fluid)......Page 380
32. Clinical Laboratory Screening of Metabolic Disease......Page 383
33. Fat Soluble Vitamins (A, D, E, K)......Page 394
34. Water Soluble Vitamins......Page 406
35. Mineral Metabolism and Abnormalities......Page 426
36. Energy Metabolism and Nutrition......Page 447
37. Detoxification and Biotransformation of Xenobiotics......Page 461
38. Environmental Pollution and Heavy Metal Poisons......Page 466
39. Nucleotides Chemistry and Metabolism......Page 472
40. Deoxyribo Nucleic Acid (DNA) Structure and Replication......Page 484
41. Transcription and Translation......Page 496
42. Inheritance, Mutations and Control of Gene Expression......Page 513
43. Recombinant DNA Technology and Gene Therapy......Page 527
44. Mechanisms of Action of Hormones......Page 535
45. Hypothalamic and Pituitary Hormones......Page 543
46. Steroid Hormones......Page 547
47. Thyroid Hormones......Page 553
48. Signal Molecules and Growth Factors......Page 558
49. Immunochemistry......Page 568
50. Biochemistry of AIDS and HIV......Page 578
51. Biochemistry of Cancer......Page 582
52. Tissue Proteins in Health and Disease......Page 596
53. Applications of Isotopes in Medicine......Page 607
54. General Techniques for Separation, Purification a......Page 614
55. Molecular Diagnostics......Page 627
Appendices......Page 640
Index......Page 652