Terpenoids: Recent Advances in Extraction, Biochemistry and Biotechnology

Cover
Title
Copyright
End User License Agreement
Contents
Preface
	ACKNOWLEDGEMENTS
	DEDICATION
List of Contributors
Biosynthesis of Terpenoids By Plants
	Akemi L. Niitsu1, Elesandro Bornhofen2 and Tábata Bergonci3,*
	INTRODUCTION
		Mevalonic Acid Pathway
		Methylerythritol Phosphate Pathway
		Isomerization of the C5 Building Blocks
		Geranyl Pyrophosphate
		Farnesyl Pyrophosphate
		Geranylgeranyl Pyrophosphate
		Cytokinin’s Biosynthesis
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Green Extraction Techniques to Obtain Bioactive Concentrates Rich in Terpenoids
	Ana Carolina de Aguiar1,*, Arthur Luiz Baião Dias1 and Juliane Viganó2
	INTRODUCTION
	LOW-PRESSURE EXTRACTION METHODS
		Microwave-Assisted Extraction (MAE)
		Ultrasound-Assisted Extraction (UAE)
	HIGH-PRESSURE EXTRACTION METHODS
		Supercritical Fluid Extraction (SFE)
		Pressurized Liquid Extraction (PLE)
		Liquefied Petroleum Gas (LPG) Extraction
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Terpenoids Produced by Plant Endophytic Fungi from Brazil and their Biological Activities: A Review from January 2015 To June 2021
	Lourivaldo Silva Santos1,*, Giselle Skelding Pinheiro Guilhon1, Railda Neyva Moreira Araujo2, Antonio José Cantanhede Filho3, Manoel Leão Lopes Junior4, Haroldo da Silva Ripardo Filho5 and Kiany Sirley Brandão Cavalcante3
	INTRODUCTION
		Terpenoids
		Monoterpenoids
			Sesquiterpenoids
		Sesterterpenoids
		Meroterpenoids
		Triterpenoids
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Volatile Terpenoids in Myrtaceae Species: Chemical Structures and Applications
	Oberdan Oliveira Ferreira1,2, Celeste de Jesus Pereira Franco2, Angelo Antônio Barbosa de Moraes2, Giovanna Moraes Siqueira2, Lidiane Diniz Nascimento3, Márcia Moraes Cascaes2, Mozaniel Santana de Oliveira1,2,* and Eloisa Helena de Aguiar Andrade3
	INTRODUCTION
		Myrtaceae Family and General Aspects
		Essential Oil of Myrtaceae Rich in Terpenoids
	APPLICATIONS
		Antioxidant Activity
		Anti-Inflammatory Activity
		Neuroprotective Activity
		Cytotoxicity Activity
		Anti-protozoan Activity
		Antidiabetic Activity
		Recent Advances in Phytotherapy
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Volatile Terpenoids of Annonaceae: Occurrence and Reported Activities
	Márcia M. Cascaes1,2,*, Giselle M. S. P. Guilhon1, Lidiane D. Nascimento2,3, Angelo A. B. de Moraes2, Sebastião G. Silva1, Jorddy Neves Cruz2, Oberdan O. Ferreira4, Mozaniel S. Oliveira2 and Eloisa H. A. Andrade1,2
	INTRODUCTION
	CHEMICAL DIVERSITY OF VOLATILE TERPENOIDS
	BIOACTIVITY OF THE ESSENTIAL OILS FROM ANNONACEAE SPECIES
		Acetylcholinesterase Inhibition
		Antimicrobial Activities
		Anti-Inflammatory Activity
		Antiproliferative and Cytotoxic Activities
		Larvicidal Activity
		Trypanocidal and Antimalarial Activities
		Other Activities
	ANTIOXIDANT POTENTIAL
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Repellent Potential of Terpenoids Against Ticks
	Tássia L. Vale1, Isabella C. Sousa1, Caio P. Tavares1, Matheus N. Gomes1, Geovane F. Silva1, Jhone R. S. Costa1, Aldilene da Silva Lima, Claudia Q. Rocha and Livio Martins Costa-Júnior1
	INTRODUCTION
		Terpenoids Repellent Against Ticks
		Bioassays to Evaluate Repellent Compounds Against Ticks
			Tick Climbing Bioassay
			Olfactometer Bioassay
			Petri Dish Bioassay
			Bioassay of the Falcon Tissue Flask Repellency
			Moving Object Bioassay
		Repellent Compound on Ticks of Medical Importance
		Repellent Compounds on Dogs’ Ticks
			Repellent Compounds on Livestock’s Ticks
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Use of Terpenoids to Control Helminths in Small Ruminants
	Dauana Mesquita-Sousa1, Victoria Miro2, Carolina R. Silva1, Juliana R. F. Pereira1, Livio M. Costa-Júnior1, Guillermo Virkel2 and Adrian Lifschitz2,*
	INTRODUCTION
		Mechanism of Action of the Anthelmintic Compound
			Neuromuscular System and Motility Control
			Terpenoids with Action in GABA
			The Action of the Terpenoids on Tubulin
			Structural Alterations
		Combination of Synthetic Anthelmintics and Terpenoids
		Influence of Pharmacological Properties of Monoterpenes on their Anthelmintic Effect
		In Vivo Anthelmintic Effect of Monoterpenes
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENT
	REFERENCES
Terpenes Behavior in Soil
	Marcia M. Mauli1, Adriana M. Meneghetti2 and Lúcia H. P. Nóbrega3
	INTRODUCTION
		Terpenoids
		Biosynthesis of IPP (Isopentyl Diphosphate) and DMAPP (Dimethylallyl Diphosphate)
			The Mevalonic Acid Pathway (MVA)
		Methylerithritol-Phosphate Pathway (MEP)
		Hemiterpenes C5
		Monoterpenes C10
		Sesquiterpenes C15
		Diterpenes C20
		Triterpenoids C30
		Tetraterpenoids C40
		Secondary Metabolites
			Allelochemicals Behavior in the Environment
			Allelochemicals Behavior in Soil
			Terpenes in Soil
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENT
	REFERENCES
Potential Use of Terpenoids in Weed Management
	Mozaniel Santana de Oliveira1,*, Jordd Nevez Cruz1, Eloisa Helena de Aguiar Andrade1 and Antônio Pedro da Silva Souza Filho2
	INTRODUCTION
		[Volatile Terpenoids]
			Volatile Terpenoids
		Monoterpenes with Phytotoxic Potential
		Sesquiterpenes with Phytotoxic Potential
		Diterpenes with Phytotoxic Potential
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGMENTS
	REFERENCES
Applications of Natural Terpenoids as Food Additives
	Fernanda Wariss Figueiredo Bezerra1,*, Giselle Cristine Melo Aires1, Lucas Cantão Freitas1, Marielba de Los Angeles Rodriguez Salazar1, Rafael Henrique Holanda Pinto1, Jorddy Neves da Cruz2 and Raul Nunes de Carvalho Junior1
	INTRODUCTION
	DIVERSITY AND CHARACTERISTICS OF TERPENOIDS IN FOOD SYSTEMS
	POSSIBLE APPLICATIONS OF THE TERPENOIDS AS FOOD ADDITIVES
		Colorants
		Flavoring Agent
		Anti-Oxidants
		Anti-Microbial
		Nutraceutical
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Potential Use of Terpenoids for Control of Insect Pests
	Murilo Fazolin1,*, Humberto Ribeiro Bizzo2 and André Fábio Medeiros Monteiro1
	INTRODUCTION
	MECHANISMS OF INSECTICIDAL ACTION OF TERPENOIDS
		Binding of GABA (Gamma-Aminobutyric Acid) Neurotransmitter to Receptors
		Binding to the Nicotinic Acetylcholine Receptor
		Inhibition of Transient Receptor Potential (TRP) Channels
		Activity on Octopamine and Tyramine Receptors
		Inhibition of Detoxification Enzymes
	INSECTICIDE FORMULATIONS USING TERPENOIDS
		Synergistic Interactions Between Terpenoids for Insecticide Formulation
		Production of Blends From Synergistic Terpenoids Present in Essential Oils and Development of Commercial Products
		Essential Oil-Based Products with High Levels of Terpenoids
		Challenges to the Production of Commercial Insecticides Based on Essential Oils and Terpenoids
		Insect Resistance to Commercial Terpenoid-Based Insecticides
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENT
	REFERENCES
Potential Antimicrobial Activities of Terpenoids
	Hamdy A. Shaaban1,* and Amr Farouk1
	INTRODUCTION
		Antibacterial Activity
		Antiviral Effect
		Terpenoids and Essential Oils as Antimicrobial Agents in Food Preservation
		The Site of Influence of Terpenoids and Essential Oils
		Factors Affecting Antimicrobial Activity
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENT
	REFERENCES
Terpenoids in Propolis and Geopropolis and Applications
	Jorddy Neves Cruz1,2,*, Mozaniel Santana de Oliveira2, Lindalva Maria de Meneses Costa Ferreira3, Daniel Santiago Pereira1, João Paulo de Holanda Neto4, Aline Carla de Medeiros5, Patrício Borges Maracajá6 and Antônio Pedro da Silva Souza Filho1
	INTRODUCTION
	TERPENOIDS PRESENT IN PROPOLIS FROM APIS MELLIFERA BEES
	TERPENOIDS PRESENT IN PROPOLIS AND GEOPROPOLIS OF STINGLESS BEES
	RECENT APPLICATIONS OF PROPOLIS AND GEOPROPOLIS IN THE FOOD AND PHARMACEUTICAL INDUSTRIES
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Terpenoids and Biotechnology
	Jorddy Neves Cruz1,2,*, Fernanda Wariss Figueiredo Bezerra3, Renan Campos e Silva4, Mozaniel Santana de Oliveira1, Márcia Moraes Cascaes1, Jose de Arimateia Rodrigues do Rego5, Antônio Pedro da Silva Souza Filho2, Daniel Santiago Pereira2 and Eloisa Helena de Aguiar Andrade1
	INTRODUCTION
	BIOTECHNOLOGY OF TERPENE PRODUCTION IN MICROORGANISMS
	PHARMACEUTICAL APPLICATIONS OF TERPENOIDS PRODUCED BY BIOTECHNOLOGICAL METHODS
	BIOTECHNOLOGICAL APPLICATIONS OF TERPENES
	CONCLUDING REMARKS
	CONSENT FOR PUBLICATION
	CONFLICT OF INTEREST
	ACKNOWLEDGEMENTS
	REFERENCES
Subject Index
Back Cover