Target Organ Toxicity in Marine and Freshwater Teleosts, Volume 2: Systems

Book Cover......Page 1
Half-Title......Page 2
Title......Page 3
Copyright......Page 4
Contents......Page 5
Contributors......Page 8
Foreword......Page 9
Copyright acknowledgments......Page 10
Direct interaction with target......Page 12
Interaction with target following absorption......Page 13
Interaction with target following biotransformation......Page 15
General cellular targets......Page 18
General types of cell defense......Page 21
Cellular regulation......Page 23
Specialized cell functions......Page 26
General cellular function......Page 28
Apoptosis and cell proliferation......Page 30
Consequences of overwhelming tissue repair......Page 32
Summary......Page 34
References......Page 35
Introduction......Page 38
Nervous system physiology......Page 39
Chlorinated hydrocarbon insecticides......Page 52
Dichlorodiphenylethanes......Page 53
Cyclodienes......Page 57
Hexachlorocyclohexanes......Page 58
Historical perspective......Page 59
Mechanism of action......Page 60
Historical perspective......Page 65
Mechanism of action......Page 66
Recovery......Page 73
Mercury......Page 74
Copper......Page 75
Cadmium......Page 76
Solvents......Page 77
Conotoxins......Page 78
Cyanotoxins......Page 79
Saxitoxin and neosaxitoxin......Page 80
Ciguatoxins......Page 83
References......Page 85
Introduction......Page 108
Innate, non-specific, and first-line defenses......Page 114
Antigen processing and presentation for specific responses......Page 120
Fish as models in biomedical research......Page 125
Historical approaches to immunotoxicology......Page 126
Polycyclic aromatic hydrocarbons......Page 127
Halogenated aromatic hydrocarbons......Page 128
Metals and organometals......Page 129
Autoimmunity and hypersensitivity: a frontier  in fish immunotoxicology......Page 130
The neuroendocrine-immune connection......Page 133
Environmental hormones may affect fish immune responses......Page 135
Summary......Page 138
References......Page 139
Introduction......Page 152
Neural basis of behavioral toxicity......Page 155
Neurotoxicity through sensory-mediated impairments......Page 156
Contaminant impacts to neuromuscular responses of fish......Page 165
Toxicant impacts on higher behavioral function......Page 173
Ecologic relevance of behavior as a predictor of contaminant  effects in the natural environment......Page 175
Conclusions......Page 177
Acknowledgments......Page 178
References......Page 179
Introduction......Page 188
Gonadotropin......Page 189
Thyroid hormones and reproduction......Page 191
Growth hormone and reproduction......Page 192
Sexual determination/differentiation......Page 193
Testicular development and spermatogenesis......Page 194
Ovarian development and oogenesis......Page 195
Transport and uptake......Page 197
Maturation-inducing hormone (MIH) production......Page 198
Oviparous, ovoviparous and viviparous embryo nourishment......Page 199
Targets for chemical toxicity......Page 200
Alteration in egg yolk nutrients......Page 202
Estrogen receptor-level effects......Page 203
Sex differentiation......Page 204
Thyroid-level effects......Page 205
Assessment of reproductive function......Page 206
Reproductive model using Japanese medaka......Page 207
References......Page 210
Index......Page 216