Systems Biology: The Challenge of Complexity

Front Matter....Pages i-xv
Integrative Synaptic Mechanisms of the Neural Network....Pages 3-10
The Molecular and Cellular Design of Networks in Motion....Pages 11-23
Bacterial Complexity: More Is Different on All Levels....Pages 25-35
How Animals Get Their Skin Patterns: Fish Pigment Pattern as a Live Turing Wave....Pages 37-46
Characterization and Application of Natural Light-Sensitive Proteins....Pages 47-56
Systems Biology of Mammalian Circadian Clocks....Pages 57-69
Toward Understanding How the Immune System Establishes a Diverse Yet Self-Tolerant T-Cell Repertoire: Stepwise Roles of Thymic Microenvironments....Pages 71-82
The Mechanisms of Motor Programming for Learned Vocalization in Songbirds....Pages 83-89
Dynamic Model of the Basal Ganglia Functions and Movement Disorders....Pages 91-97
A Posttranslational Chemical Circadian Oscillator in Cyanobacteria....Pages 101-110
The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways in an Early Analog and Late Digital Manner....Pages 111-120
Specific Features of Transient Ras and Sustained Rap1 Activation....Pages 121-127
Control and Alteration of Protein Traffic in the Cell....Pages 129-134
Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Systems Biology....Pages 135-142
A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealed by Pharmacokinetic Modeling....Pages 143-149
Molecules, Networks, and Memory....Pages 151-158
Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Network in Cerebellar Long-Term Synaptic Depression....Pages 159-168
Computational Models of Cerebellar Long-Term Memory....Pages 169-181
Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressors....Pages 183-189
The Pathogenetic Significance of Deregulated Transcription Factors in Hematological Malignancies....Pages 193-198
Ultradian Oscillation Networks in Somite Segmentation and Other Biological Events....Pages 199-207
The Cellular Basis of Dictyostelium Morphogenesis....Pages 209-220
Metabolic Information Highway: Interorgan Metabolic Communication Via the Autonomic Nervous System....Pages 221-227
Involvement of the CCR4-NOT Deadenylase Complex in the Control of Cell Growth....Pages 229-237
Reconstruction of Nuclear Reprogramming by Defined Factors....Pages 239-242
Back Matter....Pages 243-246