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دانلود کتاب Stress Resilience: Molecular and Behavioral Aspects

دانلود کتاب تاب آوری به استرس: جنبه های مولکولی و رفتاری

Stress Resilience: Molecular and Behavioral Aspects

مشخصات کتاب

Stress Resilience: Molecular and Behavioral Aspects

ویرایش:  
نویسندگان:   
سری:  
ISBN (شابک) : 0128139838, 9780128139837 
ناشر: Academic Press Inc 
سال نشر: 2019 
تعداد صفحات: 373 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 11 مگابایت 

قیمت کتاب (تومان) : 47,000



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در صورت تبدیل فایل کتاب Stress Resilience: Molecular and Behavioral Aspects به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.

توجه داشته باشید کتاب تاب آوری به استرس: جنبه های مولکولی و رفتاری نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.


توضیحاتی در مورد کتاب تاب آوری به استرس: جنبه های مولکولی و رفتاری



تاب‌آوری استرس: جنبه‌های مولکولی و رفتاری اولین مرجع موجود در وسعت کامل تحقیقات پیشرفته‌ای را که در این زمینه انجام می‌شود، ارائه می‌کند. این شامل طیف گسترده ای از دانش مولکولی پایه در مورد ارتباط بالقوه بین پدیده انعطاف پذیری و تعادل بیوشیمیایی است، اما همچنین بر مکانیسم های مولکولی و سلولی زیربنای تاب آوری استرس تمرکز دارد. کارشناسان مشهور جهانی فصل‌هایی را ارائه می‌کنند که همه چیز را از مدارهای عصبی انعطاف‌پذیری، اثرات ناملایمات اولیه زندگی، و میراث فرانسلی انعطاف‌پذیری را پوشش می‌دهد.

این کتاب بی‌نظیر و به‌موقع منبعی مناسب برای دانشمندان علوم اعصاب و روان‌پزشکان بیولوژیکی خواهد بود که می‌خواهند درک خود را از پیامدهای استرس و نحوه اجتناب از آن برخی افراد بهبود بخشند.

  • به تاب‌آوری به‌عنوان یک فرآیند و نه به‌عنوان یک صفت ایستا رویکرد می‌کند
  • دانش مولکولی اولیه را در مورد ارتباط بالقوه بین پدیده تاب‌آوری و تعادل بیوشیمیایی ارائه می‌کند
  • < li>پوشش کاملی از عوامل ژنتیکی و محیطی که به تاب آوری کمک می کنند ارائه می کند

توضیحاتی درمورد کتاب به خارجی

Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience.

This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.

  • Approaches resilience as a process rather than as a static trait
  • Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance
  • Presents thorough coverage of both the genetic and environmental factors that contribute to resilience


فهرست مطالب

Cover
Stress Resilience
Copyright
Dedication
Contributors
About the editor
Preface
Acknowledgments
1 -
A life-course, epigenetic perspective on resilience in brain and body
	Introduction
	What is stress?
	Definition of stress, allostasis, and allostatic load
	Protection and damage as the two sides of the response to experiences
	Brain as the central organ of allostasis and allostatic load/overload
		Plasticity and vulnerability of the hippocampus
		Cellular processes involved in structural plasticity
		Extension of stress effects to amygdala and prefrontal cortex
		Other mediators of structural plasticity
		Glucocorticoids as key players in PTSD vulnerability
	Sex differences
	Lessons of an ever-changing brain from gene expression
	Epigenetics: two meanings that are both important for prevention and treatment
	Individual differences and experiences throughout the life course
	Early-life experiences
	Intervention
	References
2 -
Cognitive and behavioral components of resilience to stress
	Resilience: one of many possible responses to stress or trauma
	Cognitive and behavioral components of the psychosocial factors associated with resilience
		Optimism
		Cognitive flexibility
		Active coping skills and a strong social support network
		Physical activity
		A personal moral compass
	Cultivating psychosocial factors to promote resilience
		Encourage optimism, attend to pessimism, and aspire for flexibility
		Face your fears
		Connect with a resilient role model
		Form and maintain a supportive social network
		Attend to physical health and well-being
		Attend to your personal moral compass; identify and foster your character strengths
	References
3 -
Resilience as a process instead of a trait
	Introduction
	Learning-to-cope training
	Learning to cope inferred from hormones and behavior
	Neurobiology of learning to cope
	Limitations
	Conclusions
	References
4.-
The brain mineralocorticoid receptor: a resilience factor for psychopathology?
	The brain mineralocorticoid receptor
	Mineralocorticoid receptor activation and neuronal activity
	Mineralocorticoid receptors and cognitive function in rodents
	Pharmacology, genetic variation, and vulnerability to psychopathology in humans
		The mineralocorticoid and hypothalamus-pituitary-adrenal axis activity
		The mineralocorticoid, learning, and stress appraisal in humans
		The mineralocorticoid receptor and resilience and vulnerability for psychiatric disorders
	Concluding remarks
		Brain mineralocorticoids important for resilience?
		Future directions
	References
5.-
GABAB receptors, depression, and stress resilience: a tale of two isoforms
	Introduction
	The impact of stress-related psychiatric disorders and their treatments on GABAB receptor density, gene expression and function
		Effects of antidepressants on GABAB receptor density in rodents
		Effects of antidepressants on GABAB receptor function in rodents
		Clinical evidence of altered GABAB receptor density and function in depression and the antidepressant response
		Alterations in GABAB receptor density and function in animal models of stress and depression
	Effects of GABAB receptor modulation on depression-like behaviors
	The role of GABAB1 receptor subunit isoforms in stress resilience
	Potential mechanisms underlying the differential roles of GABAB1a and GABAB1b receptor subunit isoforms in stress resilience
		The serotonin neurotransmitter system
		The hypothalamic-pituitary-adrenal axis
		Location, location, location…
		Adult hippocampal neurogenesis: a mechanism for resilience?
	Conclusions
	Acknowledgements
	References
6 -
Sex differences in the programming of stress resilience
	Introduction
	Sex x life span interaction in producing resilience
	Sex hormone x life span interaction in producing resilience
	Sex chromosome x life span interaction in producing resilience
	Conclusion
	Acknowledgments
	References
7 -
Active resilience in response to traumatic stress
	Resilience—a passive lack of effect or an active response?
	Two isozymes of glutamic acid decarboxylase
	GAD genes are regulated in response to fear and stress
	GAD is required for resilience
	GAD65 haplodeficiency conveys stress resilience
	GAD65 and stress resilience—a complex picture
	Summary
	Acknowledgments
	References
8 -
Rhythms of stress resilience
	Hypothalamic-pituitary-adrenal axis rhythms
	Circadian rhythm and stress response
	The importance of pulsatility for hormonal and behavioral response to stress
	Glucocorticoid rhythms and the response to stress in physiological and pathological conditions
	Cortisol rhythms and stress resilience in humans
	References
9 -
Mitochondrial function and stress resilience
	Introduction
	The mitochondrion
	Mitochondria in neurotransmission and synaptic plasticity
	Mitochondria and glucocorticoids
	Mitochondrial dysfunction in stress-related disorders: human studies
	Stress effects in mitochondrial function: animal studies
	Promoting stress resilience through activation of mitochondrial function
	Conclusions and future perspectives
	References
10 -
Understanding resilience: biological approaches in at-risk populations
	Introduction
	Definitions and measurement of resilience
	Biological facets of resilience
		Genetics
			Candidate studies
			Genome-wide unbiased studies
		Physiology
		Neuroimaging
	Resilience as a multidimensional trait
	Conclusion/summary
	Acknowledgments
	References
11 -
Stress resilience as a consequence of early-life adversity
	Introduction
	Early-life stress—definition of the term
	Early-life stress is a risk factor for psychiatric disorders
	Early-life stress shapes adult phenotypes
	What is the rationale for shaping adult phenotypes by early-life experiences?
	Evidence for the match/mismatch theory in humans
	Evidence for the match/mismatch theory in animal studies
	Conclusions
	References
12 -
Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
	Introduction
	The degree of predictability of maternal care influences long-lasting cognitive and emotional resilience or vulnerability
		Studying early-life experiences experimentally
			Disrupted maternal care
			Augmented/predictable maternal care
		Cognitive and emotional outcomes of early-life experiences
			A spectrum of cognitive consequences of early-life experiences
			Emotional consequences of early-life experience
	Mechanisms by which early-life experiences elicit enduring changes in neuronal, circuit, and behavioral functions
		Stress-sensitive neurons in the hypothalamus are influenced by early-life stress as well as by augmented early-life experience
		Memory consequences of early-life stress and experiences—a hippocampal story
		Early-life experiences affect a number of brain systems
		How the consequences of early-life experience are encoded long-term: transcriptional and epigenetic mechanisms
	Conclusions
	Acknowledgments
	References
13 -
Child abuse and neglect: stress responsivity and resilience
	Stress responsivity physiology
		Hypothalamic-pituitary-adrenal axis physiology
		Childhood maltreatment influence on hypothalamic-pituitary-adrenal/sympathetic nervous system response to stress
	Sympathetic nervous system
	Glucocorticoid feedback regulation of stress responsivity
	Epigenetics of stress responsivity
	Stress responsivity neural circuits
	Stress responsivity and inflammation
	Stress responsivity and resilience
	Resilient stress responses: CRFR1/OPRL1/5HTLPR/BDNF/NPY/DHEA
	Treatment/implications/future
	Financial Disclosures
	References
14 -
How genes and environment interact to shape risk and resilience to stress-related psychiatric disorders
	Introduction
	Prenatal development
	Infancy
	Childhood
	Adolescence
	Adulthood
	Conclusions
	References
15 -
Molecular characterization of the resilient brain: transcriptional and epigenetic mechanisms
	Introduction
	DNA methylation
	Chromatin modifications
	MicroRNAs
	Transcription factors
	Immune-related processes
	Neurotrophic factors
	Circuit-related molecules
	Genome-wide studies
	Future directions
	Summary
	References
16 -
The role of the CRF-urocortin system in stress resilience
	Introduction to the corticotropin-releasing factor/urocortin system
	The corticotropin-releasing factor/urocortin system as a critical mediator of the behavioral stress response
	The corticotropin-releasing factor/urocortin system mediates stress vulnerability caused by chronic stress exposure
	Corticotropin-releasing factor/urocortin system mechanisms influencing resilience
		Corticotropin-releasing factor system genetic variance x environment interactions
		Epigenetic regulation of corticotropin-releasing factor system expression
		Stress regulation of CRFR1 availability
		Stress-induced changes in CRFR2 expression
		Corticotropin-releasing protein–binding protein function
		Alterations in intracellularly activated signaling pathways
	Conclusion
	References
17 -
Intergenerational transmission of stress vulnerability and resilience
	Introduction
	Foundational populations: studies of the Dutch hunger winter and holocaust survivor offspring
	Maternal versus paternal transmission
		Maternal transmission
		Paternal transmission
	Hypothesized mechanisms of transmission
	Intergenerational transmission of resilience
	Conclusions and future directions
	References
18-
Stress and its effects across generations
	What is epigenetic inheritance?
	Why epigenetic inheritance?
	Germline versus non–germline transmission
		Germline-dependent transmission
		Non–germline transmission
	Preclinical and clinical studies of inheritance of stress susceptibility
		Inherited effects of stress in rodents
			Stress in utero
			Early life stress
			Adolescent and adult stress models
			Environmental enrichment
		Inter- and transgenerational stress effects in humans
			In utero
			Postnatal stress
		Other environmental factors that may impact stress response across generations
			Drugs of abuse
	Relevance of studying inheritance of the effects of stress for society
	References
19 -
Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience
	Glucocorticoid signaling, stress, and reslience
	Neural circuitry of stress regulation
	Limbic regulation of hypothalamo–pituitary–adrenocortical axis stress responses: hippocampus, amygdala, and prefrontal cortex
		General organizational scheme of limbic stress regulation
		Hippocampus
		Amygdala
		Medial prefrontal cortex
	Integration of hippocampal, prefrontal, and amygdala projections
		Bed nucleus of the stria terminalis
		Paraventricular thalamus
		Hypothalamic and brain stem circuitry
	Toward a neurocircuitry of stress resilience
	Acknowledgments
	References
20 -
Biomarkers of resilience and susceptibility in rodent models of stress
	Introduction
	Experimental strategies
		Prospective strategies
		Retrospective strategies
	Potential additional biomarkers
	Conclusion
	Acknowledgments
	References
21 -
Maladaptive learning and the amygdala—prefrontal circuit
	Modeling stress and anxiety disorders through behavioral paradigms of learning
	Cognitive and physiological components of emotional learning
	Associative learning in the amygdala: a preference for aversion
	Associative learning in the medial prefrontal cortex: mixed selectivity encoding
	The prelimbic and infralimbic subregions of the medial prefrontal cortex in associative learning
	Overview of amygdala—prefrontal communication during aversive emotional learning
	Directionality of amygdala–prefrontal communication during acquisition of stimulus discrimination
	Amygdala–prefrontal communication during recall of learned associations
	A unified view of mPFC–BLA circuit function in adaptive learning
	References
	Suggested Reading
22 -
Endocannabinoid signaling and stress resilience
	Impact of stress on endocannabinoid signaling
	Endocannabinoid regulation of the stress response
	Endocannabinoid signaling in the context of susceptibility and resilience to repeated stress
	Conclusions
	References
Index
	A
	B
	C
	D
	E
	F
	G
	H
	I
	L
	M
	N
	O
	P
	R
	S
	T
	U
	V
	W
Back Cover




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