Standard Operating Procedures Analytical Chemistry and Metabolism

Front Matter....Pages i-xv
Front Matter....Pages 3-3
SOP/TSB/001 Chemical Test Sample Reception....Pages 5-9
SOP/TSB/002 Test Substance Formulation — General Procedures....Pages 11-27
SOP/TSB/004 Test Substance Handling and Safety Procedures....Pages 29-33
SOP/TSB/005 Handling and Safety Procedures for Operations Involving Hazardous Materials or Potentially Hazardous Materials....Pages 35-44
SOP/TSB/020 The Use of Radioactive Substances at IRI—A Summary of Operating Procedures....Pages 45-71
SOP/TSB/021 Swab Monitoring Procedure for Radiochemical Contamination....Pages 73-74
SOP/TSB/042 General Instructions for the Preparation of Treated Diets for use in Toxicity Studies....Pages 75-79
SOP/TSB/044 Formulated Test Substance Sampling Procedures....Pages 81-84
SOP/ACH/001 Data Collation and Record Keeping in Analytical Chemistry....Pages 87-92
SOP/ACH/003 Procedure for the Receipt and Storage of Test Substances and Analytical Standards....Pages 93-95
SOP/ACH/004 Procedure for the Receipt and Storage of Biological Samples Prior to Analysis....Pages 97-99
SOP/ACH/005 The Approval of Final Analytical Methods in Analytical Chemistry....Pages 101-101
SOP/ACH/007 Archiving Procedures in Analytical Chemistry....Pages 103-105
SOP/ACH/008 Tube Labelling and Data Recording During Pharmacokinetic Studies in Animals....Pages 107-110
SOP/ACH/009 Oral Administration of Test Substances to Human Volunteers....Pages 111-113
SOP/REC/030 Studies Involving Human Volunteers....Pages 115-118
SOP/ACH/101 Studies Involving Human Volunteers....Pages 119-124
S0P/ACH/102 Use and Maintenance of “Class A” Pipettes and Standard Flasks....Pages 125-130
SOP/ACH/103 The Preparation of Reference Standards for the Generation of Standard Curves during Analysis of Plasma and Urine Samples....Pages 131-134
SOP/ACH/104 Processing of Analytical Data Derived from Liquid or Gas Chromatograms or from Selected Ion-Monitoring Computer Output....Pages 135-136
Front Matter....Pages 3-3
SOP/ACH/106 The Preparation of Reference Standards and Quality Control Samples during Analysis of Dietary Formulations....Pages 137-141
SOP/ACH/201 Instructions for Using the Perkin Elmer F17 Gas Chromatograph....Pages 143-145
SOP/ACH/204 Operation of HPLC Systems in Analytical Chemistry....Pages 147-149
SOP/ACH/205 Operation of the Finnigan 4000 GC-MS System....Pages 151-154
SOP/ACH/207 Instructions for use and Calibration of the Sartorius 2404 Balance for Critical Weighings in Analytical Chemistry....Pages 155-157
SOP/MET/100 General Record Keeping and Archiving Procedures....Pages 161-172
SOP/MET/101 Quality Control Procedures....Pages 173-175
SOP/MET/150 Procedure for the Receipt, Storage and Distribution of Non-Radioactively Labelled Drugs and Reference Standard Compounds....Pages 177-180
SOP/MET/200 Authenticity, Radiochemical Purity and Specific Activity of Supplied Radiochemicals Prior to Administration to Animals and/or Man....Pages 181-185
SOP/MET/201 The Preparation and Determination of a Radiochemical Dose....Pages 187-198
SOP/MET/205 The Receipt, Randomisation and Numbering of Animals....Pages 199-200
SOP/MET/210 The Oral and Parenteral Administration of Radiolabelled Test Substances to Rats....Pages 201-205
SOP/MET/213 The Oral and Parenteral Administration of Radiolabelled Test Substances to Dogs....Pages 207-212
SOP/MET/214 The Oral and Parenteral Administration of Radiolabelled Test Substances to Non-Human Primates....Pages 213-216
SOP/MET/220 Procedure for the Withdrawal of Blood Samples from Rats to which Radiolabelled Test Substance has been Administered....Pages 217-219
SOP/MET/223 Procedure for the Withdrawal of Blood Samples from Rats to which Radiolabelled Test Substance has been Administered....Pages 221-223
SOP/MET/224 Procedure for the Withdrawal of Blood Samples from Non-Human Primates to which Radiolabelled Test Substance has been Administered....Pages 225-226
SOP/MET/230 Collection of Excreta from Rats to which Radiolabelled Test Substance has been Administered....Pages 227-229
SOP/MET/233 Collection of Excreta from Dogs to which Radiolabelled Test Substance has been Administered....Pages 231-232
SOP/MET/234 Collection of Excreta from Non-Human Primates to which Radiolabelled Test Substance has been Administered....Pages 233-234
Front Matter....Pages 3-3
SOP/MET/240 Sample Collection at Autopsy Following Administration of Radiolabelled Test Substances....Pages 235-236
SOP/MET/250 Procedure for the Identification, Receipt, Storage and Disposal of Biological Samples....Pages 237-239
SOP/MET/255 Use of Balances....Pages 241-244
SOP/MET/260 Preparation of Biological Samples for Analysis of Radioactivity....Pages 245-255
SOP/MET/300 Operation of the Packard 306 Sample Oxidiser....Pages 257-261
SOP/MET/310 Routine Use of the Philips PW 4510/01 Automatic Liquid Scintillation Analyser....Pages 263-266
SOP/MET/320 Processing of Data from the Scintillation Counter with Particular Reference to Acceptance and Rejection Criteria....Pages 267-273
SOP/MET/330 The Topical Administration of Test Substances to Rats....Pages 275-277
SOP/MET/340 Whole Body Autoradiography....Pages 279-288
SOP/MET/350 The Use of Thin Layer Chromatography....Pages 289-292
SOP/MET/360 Use of HPLC Systems in the Operational Area of Metabolic Studies....Pages 293-295