Sphingolipids in Disease

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance....Pages 3-27
Using ASMase Knockout Mice to Model Human Diseases....Pages 29-54
New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer....Pages 55-71
Sphingolipids and Response to Chemotherapy....Pages 73-91
Lung Cancer and Lung Injury: The Dual Role of Ceramide....Pages 93-113
Sphingolipids’ Role in Radiotherapy for Prostate Cancer....Pages 115-130
Front Matter....Pages 131-131
Sphingolipid Metabolism and Atherosclerosis....Pages 133-146
Cardiovascular Effects of Sphingosine-1-Phosphate (S1P)....Pages 147-170
Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease....Pages 171-197
Front Matter....Pages 199-199
Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity....Pages 201-226
Sphingolipids in Acute Lung Injury....Pages 227-246
The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases....Pages 247-264
Ceramide in Cystic Fibrosis....Pages 265-274
Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway....Pages 275-303
Bacterial Infections and Ceramide....Pages 305-320
Viral Infections and Sphingolipids....Pages 321-340
Ceramide in Plasma Membrane Repair....Pages 341-353
Sphingolipids and Inflammatory Diseases of the Skin....Pages 355-372
Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease....Pages 373-401
Front Matter....Pages 403-403
Neuronal Forms of Gaucher Disease....Pages 405-419
Front Matter....Pages 403-403
Sphingolipids in Neuroinflammation....Pages 421-430
Sphingolipids in Psychiatric Disorders and Pain Syndromes....Pages 431-456
Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology....Pages 457-467
Back Matter....Pages 469-478