Sphingolipid Biology

Front Matter....Pages 1-1
Sphingolipids Synthesis, Transport and Cellular Signaling....Pages 3-22
Front Matter....Pages 23-23
Serine Palmitoyltransferase....Pages 25-47
Ceramide Synthase....Pages 49-56
Dihydroceramide: Sphinganine Δ4-Desaturase and C4-Hydroxylase....Pages 57-68
Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content....Pages 69-81
Glucosylceramide and Galactosylceramide Synthase....Pages 83-94
Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base....Pages 95-106
Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells....Pages 107-121
Sphingolipid Trafficking....Pages 123-139
Current Perspectives on Saccharomyces cerevisiae Sphingolipids....Pages 141-150
Front Matter....Pages 151-151
Generation of Signaling Molecules by De Novo Sphingolipid Synthesis....Pages 153-165
Overview of Acid and Neutral Sphingomyelinases in Cell Signaling....Pages 167-181
Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling....Pages 183-196
Activation of Sphingosine Kinase 1....Pages 197-206
Ceramide 1-Phosphate....Pages 207-218
Sphingosine-1-Phosphate Lyase....Pages 219-230
Front Matter....Pages 231-231
Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-lnsoluble Membrane Microdomains....Pages 233-244
Roles of Membrane Domains in the Signaling Pathway for B Cell Survival....Pages 245-251
The Role of Lipid Rafts in Axon Growth and Guidance....Pages 253-261
Sphingolipids and Multidrug Resistance of Cancer Cells....Pages 263-270
Front Matter....Pages 271-271
A New Pathological Feature of Insulin Resistance and Type 2 Diabetes: Involvement of Ganglioside GM3 and Membrane Microdomains....Pages 273-284
Neuronal Cell Death in Glycosphingolipidoses....Pages 285-293
Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses....Pages 295-307
Ganglioside and Alzheimer’s Disease....Pages 309-317
Modulation of Proteolytic Processing by Glycosphingolipids Generates Amyloid β-Peptide....Pages 319-328
Hereditary Sensory Neuropathy....Pages 329-335
Ceramide, Ceramide Kinase and Vision Defects: A BLIND Spot for LIPIDS....Pages 337-344
Fumonisin Inhibition of Ceramide Synthase: A Possible Risk Factor for Human Neural Tube Defects....Pages 345-361
Sphingolipids and Cancer....Pages 363-381
Front Matter....Pages 383-383
Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking....Pages 385-402
Sphingolipids and Lung Vascular Barrier Regulation....Pages 403-414
Signaling Mechanisms for Positive and Negative Regulation of Cell Motility by Sphingosine-1-Phosphate Receptors....Pages 415-425
Sphingosine 1-Phosphate-Related Metabolism in the Blood Vessel....Pages 427-439
Front Matter....Pages 441-441
Conventional/Conditional Knockout Mice....Pages 443-451
Biosynthesis and Function of Drosophila Glycosphingolipids....Pages 453-461
Characterization of Genes Conferring Resistance Against ISP-1/Myriocin-Induced Sphingolipid Depletion in Yeast....Pages 463-474
Lysenin: A New Probe for Sphingomyelin....Pages 475-482
Structural Biology of Sphingolipid Synthesis....Pages 483-492
A Computer Visualization Model for the De Novo Sphingolipid Biosynthetic Pathway....Pages 493-508