ویرایش:  
نویسندگان: Saunders B.C.  
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تعداد صفحات: [245] 
زبان: English 
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قیمت کتاب (تومان) : 39,000

Cambridge University Press. 1957. — 245 p. Contents Foreword
Preface
Introduction and General Survey
Phosphorofluoridates
Production on a technical scale
Phosphorodiamidic fluorides
Fluoroacetates
2-Fluoroethyl fluoroacetate
Other compounds
Particular applications
Nomenclature of Esters Containing Phosphorus
Early nomenclature
Notes
Accepted nomenclature
Notes on the agreed system for compounds containing only one phosphorus atom
Notes on the Mammalian Nervous System
The transmission of nervous effects
The autonomic nervous system
The eye page
The Phosphorofluoridates
Synthetic methods
Preparation of di-isopropyl phosphorofluoridate (D.F.P.)
Some properties of D.F.P.
Preparation of esters of phosphorofluoridic acid by means of phosphorus oxydichlorofluoride
Phosphorus oxydichlorofluoride
Alternative 'one-stage' process for the preparation of esters of phosphorofluoridic acid
Anticholinesterases
Inhibition of cholinesterase by D.F.P.
Inhibition of cholinesterase by D.F.P.: alternative technique
Detailed pharmacological studies
Enzymic destruction of D.F.P.
Radioactive D.F.P.
Reaction of esterases with radioactive di-isopropyl phosphorofluoridate
Structural requirements for high toxicity and myotic action of esters of phosphorofluoridic acid
Other compounds related to the phosphorofluoridates
Dialkyl phosphorofluoridites
1 - Phosphorodiamic Fluorides 2 - Tabun and Sarin
1 - Phosphorodiamic fluorides
Alkyl phosphoramidofluoridates
2 - Tabun
Sarin
Selected Reactions or Esters Containing Phosphorus
The Arbusov reaction
Formation of esters of phosphorous and phosphoric acids
Anhydrides
Alkylation by means of phosphorus-containing esters
Some further reactions of phosphorus trichloride
The interaction of phosphorus pentachloride and alcohols
Esters of metaphosphoric acid page
Esters of pyrophosphoric acid
Methods of phosphorylation
Dialkyl phosphoroiodidates
Dialkyl phosphorobromidates
Preparation of alkyl- and acylphosphonic acids
Carbon-phosphorus bonds
Polyphosphorus compounds
The Fluoroacetates
Methyl fluoroacetate (M.F.A.) and related compounds
2-Fluoroethanol (F.E.A.) and its derivatives
Fluoroacetamide and related compounds
2-Fluoroethyl fluoroacetate and related compounds
2:2'-Difluorodiethyl ethylene dithioglycol
Fluorine-containing ammonium salts
Relationship between physiological action and chemical constitution in the fluoroacetate series
More detailed consideration of toxic action of f fluoroacetates
Action of sodium fluoroacetate on enzymes
Cause of fluoroacetate poisoning
Naturally occurring potassium fluoroacetate
Stability of the C—F link
Enzymic rupture of a C—F bond
Other Compounds Containing the C—F Link
w-Fluorocarboxylic acids and derivatives
Synthetic methods employed in this series of compounds
Further evidence for the oxidation of w-fluorocarboxylic acids in vivo page
w-Fluorocarboxylic acids and derivatives containing an oxygen atom as a chain member
Pharmacological examination
Other examples of alternating toxicities
Antagonisms of 6 -fluorocarboxylic acids
Fluorocarbons
Insecticides
Systemic insecticides
Octamethylpyrophosphoramide (O.M.P.A.)
Oxidation of O.M.P.A.
Radioactive O.M.P.A.
Tetramethylphosphorodiamidic fluoride
Diethyl ^-nitrophenyl phosphate (paroxan)
OO'-Diethyl 0"-p-nitrophenyl phosphorothionate (parathion)
Systox
Tetraethyl pyrophosphate (T.E.P.P.)
Sodium fluoroacetate
Comparison of the action of organo-phosphorus compounds on mammals and insects
Esterase Activity and Medical Aspects
Further consideration of esterase activity
Structural requirements for anticholinesterase activity
Theoretical considerations page
Active centre in chymotrypsin
An irreversible cholinesterase inhibitor in white clover
Anticholinesterases containing quaternary N groups
Medical aspects of D.F.P. and related compounds
The use of D.F.P. in post-operative paralytic ileus
D.F.P. and my asthenia gravis
Protection in vitro of cholinesterase against organophosphorus compounds
Protection against benzoylcholine by the injection of pseudo-cholinesterase
Demyelination of nerve fibres
Permeability of nerve fibres
D.F.P. and cell growth
Cholinesterase in the retina
Organic phosphates as radiosensitizers in the radiotherapy of malignant tumours
Epilogue Appendices A. Determination of Fluorine in Organic Compounds Determination of fluorine in phosphorofluoridates
Breakdown of the phosphorofluoridate
The lead chlorofluoride method
Specimen determination of fluorine in disopropyl phosphorofluoridate
Determination of fluorine in fluoroacetates
Fluoroacetamide standard
Specimen determination of fluorine in methyl fluoroacetate by fusion with sodium
Standardization of the 'sodium peroxide bomb' method with pure fluoroacetamide
Fluorine determination of radioactive D.F.P. by thorium nitrate
Reagents
Method
Standardization of thorium nitrate solution using A.R. sodium fluoride
Determination of fluorine in D.F.P. B. Table of Properties of Typical Fluorocompounds C. First-Aid Treatment for Nerve-Gas Poisoning General Bibiliography Index