Soft Nanomaterials (World Scientific Series in Nanoscience and Nanotechnology)

Contents
Preface
Chapter 1. Self-Assembling Supramolecular Nanostructures for Drug Delivery
	1.1. Introduction
	1.2. Engineering a Drug Delivery System
	1.3. The Building Blocks of Self-assembly
		1.3.1. Peptide based self-assembly
		1.3.2. Block copolymer self-assembly
	1.4. Tumor Targeting and Drug Release
		1.4.1. Ligand targeting and enzymatic release
		1.4.2. pH-sensitive release
		1.4.3. Light-sensitive release
	Structural Morphology and Integrity
	1.5. The Future of Nanomedicine and Its Clinical Translation
	References
Chapter 2. Bioactive Supramolecular Assembly of Peptide Amphiphiles to Control Cellular Fate
	2.1. Introduction
	2.2. Self-assembly of Peptide Amphiphiles
		2.2.1. Bio catalytic peptide amphihpiles
		2.2.2. Nanostructure formation by following nature’s principle
	2.3. Post Assembly to Control Cellular Fate
		2.3.1. Bioactive assembled structure from peptide amphiphiles
		2.3.2. Antibacterial activity of self-assembled peptides
		2.3.3. Drug delivery applications
		2.3.4. Biomacromolecule delivery of self-assembled peptides
		2.3.5. Tissue engineering
	2.4. In-situ Assembly to Control Cellular Fate
		2.4.1. Intracellular assembly of peptide amphiphile
		2.4.2. Self-assembly in the pericellular space
		2.4.3. Intracellular assembly triggered by enzyme
	2.5. Summary and Future Outlook
	References
Chapter 3. Supramolecular Gel Electrophoresis of Protein
	3.1. Introduction
	3.2. Supramolecular Gel Electrophoresis (SUGE) for Denatured Proteins
		3.2.1. Development of SDS-SUGE
		3.2.2. Effect of ionic surfactant concentration on SDS-SUGE
	3.3. Supramolecular Gel Electrophoresis (SUGE) for Native Proteins
		3.3.1. Development of a low molecular weight hydrogelator
		3.3.2. Development of Native-SUGE
		3.3.3. Affinity electrophoresis of lectin
	3.4. Conclusion
	References
Chapter 4. Self-assembly of Polymer-grafted Inorganic Nanoparticles into Functional Hybrid Materials
	4.1. Introduction
	4.2. Structural Parameters of HINPs
	4.3. Tailored Synthesis of HINPs
	4.4. Anisotropic Self-assembly of HINPs
		4.4.1. Self-assembly of HINPs in condensed state
			4.4.1.1. Assembly at the liquid/Air interface
			4.4.1.2. Assembly within BCP film
			4.4.1.3. Assembly of neat HINPs
		4.4.2. Self-assembly of HINPs in solutions
			4.4.2.1. HINPs tethered with mixed polymers
			4.4.2.2. HINPs grafted with amphiphilic BCPs
				4.4.2.2.1. Self-assembly by film rehydration
				4.4.2.2.2. Self-assembly in selective solvent
				4.4.2.2.3. Concurrent self-assembly of amphiphilic HINPs with BCPs
				4.4.2.2.4. Kinetically-controlled self-assembly in microfluidics
	4.5. Biomedical Applications of Vesicular Nanocomposites
	4.6. Conclusions and Perspective
	References
Chapter 5. Surface Coated NIR Light-Responsive Nanostructures for Imaging and Therapeutic Applications
	5.1. Introduction
	5.2. Surface Coated Gold-based Nanomaterials
		5.2.1. Drug delivery
		5.2.2. Photothermal therapy
		5.2.3. Photodynamic therapy
	5.3. Surface Coated Upconversion Nanoparticles
		5.3.1. Drug delivery
		5.3.2. Photothermal therapy
		5.3.3. Photodynamic therapy
	5.4. Surface Coated Carbon Nanotubes
		5.4.1. Drug delivery
		5.4.2. Photothermal therapy
		5.4.3. Photodynamic therapy
	5.5. Surface Coated 2D Nanomaterials
		5.5.1. Graphene oxide (GO)
		5.5.2. Molybdenum disulfide
		5.5.3. Black phosphorus
	5.6. Conclusion and Current Challenges
	References
Chapter 6. Surface Functionalization through Polymer Segregation
	6.1. Introduction
	References
Chapter 7. Nucleic Acid Hairpins: A Robust and Powerful Motif for Molecular Devices
	7.1. Introduction
	7.2. What are Hairpins?
		7.2.1. DNA hairpins
		7.2.2. Kissed complex
		7.2.3. Catalytic opening strand
		7.2.4. Internal and external loop opening
		7.2.5. Interest in nucleic acid hairpins
	7.3. An Energy Perspective: How Much Power Do Hairpin Based Systems Really Pack?
	7.4. Nucleic Acid Circuits
	7.5. DNA Detection Mechanisms
		7.5.1. Hybridization chain reaction
	7.6. Locomotive Devices, Fuel
	7.7. An Enzyme-free Autocatalytic Self-replicating DNA Nanodevice
		7.7.1. Transducers
		7.7.2. Irreversible hairpin opening
	7.8. Summary
	7.9. Future Challenges
		7.9.1. Future extensions to self-replication and detection in vivo
		7.9.2. Future extensions to self-replication of large DNA nanostructures
	References
Index